Fabrication of ssDNA functionalized MoS<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" altimg="si43.svg" display="inline" id="d1e253"><mml:msub><mml:mrow/><mml:mrow><mml:mn>2</mml:mn></mml:mrow></mml:msub></mml:math> nanoflakes based label-free electrochemical biosensor for explicit silver ion detection at sub-pico molar level

Pal, Chittatosh; Kumar, Abhinandan; Majumder, Subrata

doi:10.1016/j.colsurfa.2022.130241

Cited by 9 publications

(4 citation statements)

References 23 publications

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“…The ensemble of mismatch-containing DNA and nanomaterials is an effective strategy to improve the detection limit by taking advantage of amplified local DNA concentration and interaction surfaces. Recently, Pal et al have reported an electrochemical Ag + sensor based on DNA hairpin-functionalized nanoflakes with a detection limit of 0.8 pM [ 38 ]. Comparing with the detection limits of other sensors using only mismatch-containing DNA (i-motifs and hairpins), detection limit of the M-DNA sensor was the lowest.…”

Section: Resultsmentioning

confidence: 99%

“…Ag + can induce the formation of DNA i-motif or hairpin structures that contain C·C mismatch(es), thus giving reporting signals upon DNA conformational change [ 26 , 29 , 30 , 31 , 32 , 33 ]. Moreover, the duplex or hairpin-forming strands can also be assembled onto nanomaterials for signal amplification [ 34 , 35 , 36 , 37 , 38 ]. The second strategy can achieve a low detection limit, but the reported ones generally used relatively long oligonucleotides, which might make the Ag + -induced DNA conformational change slow.…”

Section: Introductionmentioning

confidence: 99%

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A Novel Minidumbbell DNA-Based Sensor for Silver Ion Detection

et al. 2023

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Silver ion (Ag+) is one of the most common heavy metal ions that cause environmental pollution and affect human health, and therefore, its detection is of great importance in the field of analytical chemistry. Here, we report an 8-nucleotide (nt) minidumbbell DNA-based sensor (M-DNA) for Ag+ detection. The minidumbbell contained a unique reverse wobble C·C mispair in the minor groove, which served as the binding site for Ag+. The M-DNA sensor could achieve a detection limit of 2.1 nM and sense Ag+ in real environmental samples with high accuracy. More importantly, the M-DNA sensor exhibited advantages of fast kinetics and easy operation owing to the usage of an ultrashort oligonucleotide. The minidumbbell represents a new and minimal non-B DNA structural motif for Ag+ sensing, allowing for the further development of on-site environmental Ag+ detection devices.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A Novel Minidumbbell DNA-Based Sensor for Silver Ion Detection

et al. 2023

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“…By introducing the aptamer as a target recognition ligand, analytes can be quantitatively analyzed according to the changes in optical signals caused by the structural transformation before and after the recognition of the aptamer. 72 MoS 2 has a particular affinity for ssDNA. 73 When the aptamer recognizes the analyte, structural changes occur, resulting in MoS 2 either exhibiting or no longer displaying a specific affinity for ssDNA, thus either enhancing or inhibiting the FRET phenomenon.…”

Section: Ucnps–mos2 Nanocomposites For Biological Applicationsmentioning

confidence: 99%

Recent progress of UCNPs–MoS₂ nanocomposites as a platform for biological applications

Wang,

Zhong

et al. 2024

J. Mater. Chem. B

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“…The sensing of silver ions had been performed using a biosensor based on functionalized MoS 2 . Pal and collaborators [ 51 ] functionalized MoS 2 with carboxyl groups by sonication with potassium hydroxide and monochloroacetic acid in deionized water. FESEM was used to analyze the layered structure of functionalized MoS 2 and Raman spectroscopy to prove the COOH-functionalization of MoS 2 .…”

Section: Metal Sensorsmentioning

confidence: 99%

Chemically Functionalized 2D Transition Metal Dichalcogenides for Sensors

Acosta,

Quintana

2024

Sensors

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The goal of the sensor industry is to develop innovative, energy-efficient, and reliable devices to detect molecules relevant to economically important sectors such as clinical diagnoses, environmental monitoring, food safety, and wearables. The current demand for portable, fast, sensitive, and high-throughput platforms to detect a plethora of new analytes is continuously increasing. The 2D transition metal dichalcogenides (2D-TMDs) are excellent candidates to fully meet the stringent demands in the sensor industry; 2D-TMDs properties, such as atomic thickness, large surface area, and tailored electrical conductivity, match those descriptions of active sensor materials. However, the detection capability of 2D-TMDs is limited by their intrinsic tendency to aggregate and settle, which reduces the surface area available for detection, in addition to the weak interactions that pristine 2D-TMDs normally exhibit with analytes. Chemical functionalization has been proposed as a consensus solution to these limitations. Tailored surface modification of 2D-TMDs, either by covalent functionalization, non-covalent functionalization, or a mixture of both, allows for improved specificity of the surface–analyte interaction while reducing van der Waals forces between 2D-TMDs avoiding agglomeration and precipitation. From this perspective, we review the recent advances in improving the detection of biomolecules, heavy metals, and gases using chemically functionalized 2D-TMDs. Covalent and non-covalent functionalized 2D-TMDs are commonly used for the detection of biomolecules and metals, while 2D-TMDs functionalized with metal nanoparticles are used for gas and Raman sensors. Finally, we describe the limitations and further strategies that might pave the way for miniaturized, flexible, smart, and low-cost sensing devices.

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Fabrication of ssDNA functionalized MoS2 nanoflakes based label-free electrochemical biosensor for explicit silver ion detection at sub-pico molar level

Cited by 9 publications

References 23 publications

A Novel Minidumbbell DNA-Based Sensor for Silver Ion Detection

A Novel Minidumbbell DNA-Based Sensor for Silver Ion Detection

Recent progress of UCNPs–MoS₂ nanocomposites as a platform for biological applications

Chemically Functionalized 2D Transition Metal Dichalcogenides for Sensors

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Fabrication of ssDNA functionalized MoS2 nanoflakes based label-free electrochemical biosensor for explicit silver ion detection at sub-pico molar level

Cited by 9 publications

References 23 publications

A Novel Minidumbbell DNA-Based Sensor for Silver Ion Detection

A Novel Minidumbbell DNA-Based Sensor for Silver Ion Detection

Recent progress of UCNPs–MoS2 nanocomposites as a platform for biological applications

Chemically Functionalized 2D Transition Metal Dichalcogenides for Sensors

Contact Info

Product

Resources

About

Recent progress of UCNPs–MoS₂ nanocomposites as a platform for biological applications