Fabrication of silver nanoparticle-containing electrospun polycaprolactone membrane coated with chitosan oligosaccharides for skin wound care

Tang, Tuan-Ngan; Nguyen, Tran Hung; Tran, Chien Minh; Doan, Vinh Khanh; Nguyen, Ngoc Thi-thanh; Vu, Binh Thanh; Dang, Nhi Ngoc‐Thao; Duong, Thanh Tu; Phạm, Việt Hùng; Tran, Lam Dai; Nguyen, Thi-Hiep

doi:10.1016/j.jsamd.2023.100582

Cited by 6 publications

(5 citation statements)

References 50 publications

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“…The H&E staining of grou treated with SA/CS-Ser/Cur/AgNPs displayed improved epithelial regeneration, high expression of CD31, and lower levels of inflammatory cells (TNF-α). Silver-loaded electrospun nanofibers displayed high in vitro cell safety in L9 mouse fibroblast cells after incubation for 24 h [91]. The loading of AgNPs synergistical promoted in vitro microbial inhibition of P. aeruginosa and S. aureus, which led to their vivo wound healing evaluation on a 1 cm round wound incised on albino mice.…”

Section: Zhou Et Al Developed Cs Sponges (Cs-it/agnpsmentioning

confidence: 98%

“…Silver-loaded electrospun nanofibers displayed high in vitro cell safety in L929 mouse fibroblast cells after incubation for 24 h [ 91 ]. The loading of AgNPs synergistically promoted in vitro microbial inhibition of P. aeruginosa and S. aureus , which led to their in vivo wound healing evaluation on a 1 cm round wound incised on albino mice.…”

Section: Polymer-based Wound Dressings Loaded With Bioactive Materialsmentioning

confidence: 99%

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Polymer-Based Functional Materials Loaded with Metal-Based Nanoparticles as Potential Scaffolds for the Management of Infected Wounds

Nqoro,

Taziwa

2024

Pharmaceutics

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Wound infection due to bacterial invasion at the wound site is one of the primary challenges associated with delayed wound healing. Microorganisms tend to form biofilms that protect them from harm, leading to their multidrug resistance. The alarming increase in antibiotic resistance poses a threat to wound healing. Hence, the urgent need for novel wound dressing materials capable of managing bacterial infection is crucial for expediting wound recovery. There is considerable interest in polymeric wound dressings embedded with bioactive substances, such as metal-based nanoparticles, as potential solutions for treating microbially infected wounds. Metal-based nanoparticles have been widely used for the management of infected wounds due to their broad antimicrobial efficacy. This review focuses on polymer-based and bioactive wound dressings loaded with metal-based nanoparticles like silver, gold, magnesium oxide, or zinc oxide. When compared, zinc oxide-loaded dressings exhibited higher antibacterial activity against Gram-positive strains and silver nanoparticle-loaded dressings against gram-negative strains. However, wound dressings infused with both nanoparticles displayed a synergistic effect against both strains of bacteria. Furthermore, these dressings displayed antibiofilm activity and the generation of reactive oxygen species while accelerating wound closure both in vitro and in vivo.

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Section: Zhou Et Al Developed Cs Sponges (Cs-it/agnpsmentioning

confidence: 98%

Section: Polymer-based Wound Dressings Loaded With Bioactive Materialsmentioning

confidence: 99%

Polymer-Based Functional Materials Loaded with Metal-Based Nanoparticles as Potential Scaffolds for the Management of Infected Wounds

Nqoro,

Taziwa

2024

Pharmaceutics

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“…The release of nanoparticles from the dressings was characterized by an initial rapid release followed by a sustained drug release. The membranes containing AgNPs significantly resulted in larger inhibition zones when compared to plain membranes, revealing an excellent antibacterial efficacy of Ag nanoparticles in the membranes [ 139 ]. El-Aassar et al fabricated chitosan/gelatin/PVP hybrid membranes encapsulated with AgNPs green synthesized utilizing Citrullus colocynthis plant extract.…”

Section: Chitosan-based Scaffolds Incorporated With Silver Nanoparticlesmentioning

confidence: 99%

“…The hydrophobic layer protects the wound from liquids and permits water-vapor diffusion and gaseous exchange. Foams can be sterilized and used in injuries without resulting in pain to the patient if their parameters, such as mechanical features, are tailored appropriately [ 139 ]. The advantages of foams include their capacity to prevent maceration on the injury, enhance gaseous exchange, offer appropriate moisture for wound beds, and absorb excess wound exudate, making them suitable for treating diabetic ulcers, burns, etc.…”

Section: Chitosan-based Scaffolds Incorporated With Silver Nanoparticlesmentioning

confidence: 99%

Chitosan-Based Scaffolds Incorporated with Silver Nanoparticles for the Treatment of Infected Wounds

Alven,

Aderibigbe

2024

Pharmaceutics

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Bacterial infections are major problems in wound care due to their impact on the retarded process of wound healing, leading to chronic wounds. Most of the presently utilized wound dressing products exhibit poor antimicrobial properties. Wound dressings formulated from chitosan have been reported to be effective for treating infected wounds, resulting from the antibacterial properties of chitosan. The antibacterial properties of chitosan-based wound dressings can be further enhanced by incorporating metallic nanoparticles into them, such as silver, zinc, titanium, etc. The incorporation of silver nanoparticles into chitosan-based wound dressings has been widely explored in the design of antimicrobial wound dressings. The incorporation of silver nanoparticles into chitosan-based wound dressings promotes accelerated wound-healing processes due to enhanced antimicrobial activity. The accelerated wound healing by these metal-based nanoparticles is via the regulation of re-epithelialization and inflammation without affecting the viability of normal cells. However, there have been few reports that evaluate these wound dressings in infectious animal models to prove their efficacy. The in vivo toxicity of silver nanoparticles still needs to be addressed, revealing the need for further preclinical and clinical trials. The fabrication of wound dressings incorporated with silver nanoparticles has not been fully explored, especially for wounds requiring immediate treatment. The possible interactions between silver nanoparticles and chitosan scaffolds that result in synergistic effects still need to be understood and studied. This review provides a comprehensive report on the preclinical outcomes of chitosan wound dressing materials loaded with silver nanoparticles for managing infected wounds.

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“…This is because Ag nanoparticles have potential advantages such as increasing product stability, increasing absorption, and the ability to give special effects to the skin. (Tang et al, 2023). Using silver nanoparticles in liquid soap can provide antibacterial benefits, thus helping to reduce the growth and spread of bacteria on the skin.…”

Section: Introductionmentioning

confidence: 99%

Turi leaf extract Ag nanoparticle liquid soap (Review of physical properties and antibacterial activity)

Amananti,

Budi Riyanta

2024

J. Halal Sci. Res.

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Research has been carried out on manufacturing liquid soap silver nanoparticles of Turi leaf extract. Ag nanoparticles have been used in various cosmetic and personal care products. This is because Ag nanoparticles have potential advantages such as increasing product stability, increasing absorption, and the ability to give special effects to the skin. From the physical properties test results, all soap formulas meet the standards set based on organoleptic, physical properties, pH, density, and viscosity. This research discusses the antibacterial activity of liquid soap. Formula 1 showed better antibacterial activity than formulas 2 and 3, with an inhibitory area reaching 23.84 mm. This can be explained by the fact that Formula 1 has a smaller particle size, namely 2161 nm. Formula 1 has the lowest AgNO3 concentration. The higher the concentration of AgNO3 used in the synthesis, the greater the amount of Ag+ that must be reduced, resulting in greater agglomeration and a larger size distribution of Ag nanoparticles.

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Fabrication of silver nanoparticle-containing electrospun polycaprolactone membrane coated with chitosan oligosaccharides for skin wound care

Cited by 6 publications

References 50 publications

Polymer-Based Functional Materials Loaded with Metal-Based Nanoparticles as Potential Scaffolds for the Management of Infected Wounds

Polymer-Based Functional Materials Loaded with Metal-Based Nanoparticles as Potential Scaffolds for the Management of Infected Wounds

Chitosan-Based Scaffolds Incorporated with Silver Nanoparticles for the Treatment of Infected Wounds

Turi leaf extract Ag nanoparticle liquid soap (Review of physical properties and antibacterial activity)

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