Fabrication of Silver- and Zinc-Doped Hydroxyapatite Coatings for Enhancing Antimicrobial Effect

Predoi, Daniela; Iconaru, Simona Liliana; Predoi, Mihai Valentin

doi:10.3390/coatings10090905

Cited by 34 publications

(35 citation statements)

References 47 publications

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“…The peaks associated to the FTIR spectrum of CTAB located in the range of 890–110 cm −1 could not be observed in the FTIR spectrum of HAp-CTAB composite due to broad bands present in this region and associated with PO 4 3− vibrations. The achieved results were in accordance with preceding studies [ 35 , 37 , 38 , 39 , 40 , 41 ] confirming the formation of the HAp-CTAB composite.…”

Section: Resultssupporting

confidence: 92%

Preparation of Porous Hydroxyapatite Using Cetyl Trimethyl Ammonium Bromide as Surfactant for the Removal of Lead Ions from Aquatic Solutions

et al. 2021

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In the present study, a new low-cost bioceramic nanocomposite based on porous hydroxyapatite (HAp) and cetyl trimethyl ammonium bromide (CTAB) as surfactant was successfully obtained by a simple chemical co-precipitation. The composition and structure of the HAp-CTAB were characterized by X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy, transmission electron microscopy (TEM), scanning electron microscope (SEM) equipped with an energy dispersive X-ray (EDX) spectrometer, and N2 adsorption/desorption analysis. The capacity of HAp-CTAB nanocomposites to remove the lead ions from aqueous solutions was studied by adsorption batch experiments and proved by Langmuir and Freundlich models. The Pb2+ removal efficiency of HAp-CTAB biocomposite was also confirmed by non-destructive ultrasound studies. The cytotoxicity assays showed that the HAp-CTAB nanocomposites did not induce any significant morphological changes of HeLa cells after 24 h of incubation or other toxic effects. Taken together, our results suggests that the obtained porous HAp-CTAB powder could be used for the decontamination of water polluted with heavy metals, such as Pb2+.

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Section: Resultssupporting

confidence: 92%

Preparation of Porous Hydroxyapatite Using Cetyl Trimethyl Ammonium Bromide as Surfactant for the Removal of Lead Ions from Aquatic Solutions

et al. 2021

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“…The uptakes of Ag + ions by the green and amber glass-derived tobermorites are within the reported range for zeolite Y [44,45] and greater than those of analcime [41], chabazite [31], and montmorillonite [48]. However, the extents of Ag + -loading of TG4 and TA4 are inferior to those of zeolites A [30,32] and X [43], ZSM-5 [45], clinoptilolite [47], and the titanosilicate frameworks JDF-L1 and AM-4 [46]. Zn 2+ -uptakes by TG4 and TA4 are comparable with that of titanosilicate AM-4 [46], superior to those of analcime [41], ZSM-5 [45], JDF-L1 [46], chabazite [31], clinoptilolite [47] and montmorillonite [48], and inferior to those of zeolites A [30,42], X [43] and Y [44,45].…”

Section: Discussionsupporting

confidence: 67%

“…Ag + -and Zn 2+ -bearing zeolites, clays, minerals, and nanoparticles have been incorporated into a wide range of polymer composites to confer antimicrobial properties on packaging, films, coatings, wound dressings, medical devices, and equipment [30][31][32][33][34]. Given this, it is considered that waste glass-derived tobermorites may be effective carriers of Ag + and Zn 2+ ions for incorporation into antimicrobial polymer composites.…”

Section: Introductionmentioning

confidence: 99%

Waste Glass-Derived Tobermorite Carriers for Ag+ and Zn2+ Ions

Rahman

Coleman

2022

J. Compos. Sci.

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In this study, the layer-lattice calcium silicate hydrate mineral, tobermorite, was synthesized from waste green or amber container glass and separately ion-exchanged with Ag+ or Zn2+ ions under batch conditions. Hydrothermal treatment of stoichiometrically adjusted mixtures of waste glass and calcium oxide in 4 M NaOH(aq) at 125 °C yielded tobermorite products of ~75% crystallinity with mean silicate chain lengths of 17 units after one week. Maximum uptake of Zn2+ ions, ~0.55 mmol g−1, occurred after 72 h, and maximum uptake of Ag+ ions, ~0.59 mmol g−1, was established within 6 h. No significant differences in structure or ion-exchange behavior were observed between the tobermorites derived from either green or amber glass. Composite membranes of the biopolymer, chitosan, incorporating the original or ion-exchanged tobermorite phases were prepared by solvent casting, and their antimicrobial activities against S. aureus and E. coli were evaluated using the Kirby–Bauer assay. S. aureus and E. coli formed biofilms on pure chitosan and chitosan surfaces blended with the original tobermorites, whereas the composites containing Zn2+-substituted tobermorites defended against bacterial colonization. Distinct, clear zones were observed around the composites containing Ag+-substituted tobermorites which arose from the migration of the labile Ag+ ions from the lattices. This research has indicated that waste glass-derived tobermorites are functional carriers for antimicrobial ions with potential applications as fillers in polymeric composites to defend against the proliferation and transmission of pathogenic bacteria.

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“…More information regarding the surface morphology of the NBrHAp composite thin films was obtained by metallographic and optical microscopy. All the experiments were performed in agreement with the procedure previously reported [38,39] in ambient conditions. Both microscopy images (optical and metallographic) were obtained using a 10× magnification objective.…”

Section: Characterization Methodsmentioning

confidence: 99%

Nitrogen and Bromide Co-Doped Hydroxyapatite Thin Films with Antimicrobial Properties

et al. 2021

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Hydroxyapatite (Ca10(PO4)6(OH)2, HAp), due to its high biocompatibility, is widely used as biomaterial. Doping with various ions of hydroxyapatite is performed to acquire properties as close as possible to the biological apatite present in bones and teeth. In this research the results of a study performed on thin films of hydroxyapatite co-doped with nitrogen and bromine (NBrHAp) are presented for the first time. The NBrHAp suspension was obtained by performing the adapted co-precipitation method using cetyltrimethylammonium bromide (CTAB). The thin layers of NBrHAp were obtained by spin-coating. The stability of the NBrHAp suspension was examined by ultrasound measurements. The thin layers obtained by the spin-coating method were examined by scanning electron microscopy (SEM), optical microscopy (OM), and metallographic microscopy (MM). The presence of nitrogen and bromine were highlighted by energy-dispersive X-ray spectroscopy (EDS) and X-ray photoelectron spectroscopy (XPS) studies. Fourier transform infrared spectroscopy (FTIR) was used to highlight the chemical status of nitrogen and bromine. In addition, the powder obtained from the NBrHAp suspension was analyzed by XRD. Moreover, the in vitro antimicrobial activity of the NBrHAp suspensions and coatings was investigated using the reference microbial strains Staphylococcus aureus ATCC 25923, Escherichia coli ATCC 25922, and Candida albicans ATCC 10231. The results highlighted the successful obtainment of N and Br co-doped hydroxyapatite suspension for the first time by an adapted co-precipitation method. The obtained suspension was used to produce pure NBrHAp composite thin films with superior morphological properties. The NBrHAp suspensions and coatings exhibited in vitro antimicrobial activity against bacterial and fungal strains and revealed their good antimicrobial activity.

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Fabrication of Silver- and Zinc-Doped Hydroxyapatite Coatings for Enhancing Antimicrobial Effect

Cited by 34 publications

References 47 publications

Preparation of Porous Hydroxyapatite Using Cetyl Trimethyl Ammonium Bromide as Surfactant for the Removal of Lead Ions from Aquatic Solutions

Preparation of Porous Hydroxyapatite Using Cetyl Trimethyl Ammonium Bromide as Surfactant for the Removal of Lead Ions from Aquatic Solutions

Waste Glass-Derived Tobermorite Carriers for Ag+ and Zn2+ Ions

Nitrogen and Bromide Co-Doped Hydroxyapatite Thin Films with Antimicrobial Properties

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