Fabrication of radially aligned electrospun nanofibers in a three-dimensional conical shape

Vong, Michel; Radacsi, Norbert

doi:10.1515/esp-2018-0001

Cited by 6 publications

(3 citation statements)

References 56 publications

(57 reference statements)

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“…Nanofiber-based materials are becoming more propular due to their marvelous characteristics such as such as high flexibility, low density, huge porosity, high specific surface areas and tiny pore sizes ( Hu et al, 2014 ). Electrospinning is an uncomplicated and popular method used to fabricate nanosized or microsized fibers employing an electrostatic field to stretch the polymer droplet to form nanofibers ( Thenmozhi et al, 2017 , Vong and Radacsi, 2018 ). The process of electrospinning has been widely applied in several fields such as tissue engineering, drug delivery systems, wound dressing, filtration, etc.…”

Section: Introductionmentioning

confidence: 99%

Influence of nanofiber alignment on the release of a water-soluble drug from cellulose acetate nanofibers

Patrojanasophon

Tidjarat

Opanasopit

et al. 2020

Saudi Pharmaceutical Journal

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Cellulose acetate nanofibers with different degrees of alignment (randomly aligned (RA), partially aligned (PA), and highly aligned (HA)) were produced using an electrospinning technique. The different degrees of alignment were obtained by adjusting the rotation speed of the collector. Alpha-arbutin (3% w/w) employed as a model water-soluble compound was incorporated into the nanofibers during the fabrication process. The drug release characteristics were investigated using the nanofiber mats with the same size and weight. The prepared nanofibers with different degrees of alignment showed similar physical characteristics, including the fiber diameter, drug loading efficiency and capacity, and molecular form of the drug in the fibers. Interestingly, alpha-arbutin was released from HA nanofibers at a significantly faster rate than the PA and RA nanofibers. Eighty percent of the drug was released into the medium in 1.7, 4.2, and 9.4 min for HA, PA, and RA nanofibers, respectively. The orientation of nanofibers played a crucial role in governing the drug release, probably by creating network meshes with different degrees of entanglement, affecting the diffusion of drug to the external medium. Consequently, this approach can be used as a simple means of achieving immediate-release or fast-acting characteristics of cellulose-based formulations containing a water-soluble drug.

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Section: Introductionmentioning

confidence: 99%

Influence of nanofiber alignment on the release of a water-soluble drug from cellulose acetate nanofibers

Patrojanasophon

Tidjarat

Opanasopit

et al. 2020

Saudi Pharmaceutical Journal

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“…When the corrugated collector is used to produce a P4VPBuMA aligned fibrous pattern, the needle-to-collector distance should be shorter (5 cm) so that the ejected fibers can accumulate toward the center of the collector. PVP is a widely used polymer that has been processed by electrospinning, resulting in the fabrication of randomly oriented and aligned (nano)fibrous materials destined for use as tissue engineering scaffolds with controllable mechanical properties and multifunctionalities, , multifunctional fibrous membranes for magnetic hyperthermia applications, sensors and actuators, robust hydrophilic polymer fibers sensitized by perovskite nanocrystal emitters, catalytic fibrous matrixes incorporating inorganic catalytic nanoparticles, functional electrospun fibers employed in water remediation processes, and so on. − …”

Section: Resultsmentioning

confidence: 99%

Highly Aligned Electrospun Polymer Fibers Produced Using a Corrugated Static Collector

Papaparaskeva

Papagiorgis

Itskos

et al. 2021

ACS Appl. Polym. Mater.

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Fiber alignment via electrospinning is a challenging process that requires complex optimization because of the synergistic contribution of the solution, processing, and environmental parameters. Much of the work has focused on the design of collectors that enable fiber alignment, in contrast to that of the stationary, flat collector where randomly oriented fibers are deposited. However, in most cases, the proposed collectors have either movable parts or complicated configurations. The present study focuses on a simplified design concept involving the use of a corrugated metallic collector in the production of highly aligned electrospun fibers based on three polymer systems exhibiting different physicochemical characteristics: Polyvinylpyrrolidone (PVP) (insulating), poly(3-hexylthiophene-2,5-diyl) (P3HT)-rich polymer blend (semiconducting), and poly(4-vinylpyridine-co-butyl methacrylate) (P4VPBuMA) (polyelectrolyte). The electric field profile developed in the presence of the corrugated collector was simulated by means of finite element analysis and compared to that of the conventional flat collector. Most importantly, electrospun meshes with an exceptionally high degree of alignment (up to 95%) after a prolonged electrospinning time were produced in all cases, thus demonstrating the effectiveness of this simple collector design approach on the production of highly oriented electrospun polymer fibers of various chemical compositions. Electro-optical characterization of the P3HT systems shows that oriented fibers exhibit identical optical properties to fibers with random orientation, indicating that the molecular conformation and structural state of the fibers is not affected by the alignment process during electrospinning. On the other hand, aligned fibers exhibit superior electrical properties, as evidenced by the suppression of hysteresis and an increase of photoconductance by up to 2.5 times compared to the respective characteristics of randomly oriented fibers due to an alignment-induced reduction of capacitive parasitic effects.

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“…and diameter. One example of this is the research by Vong et al that performed a parametric study to investigate the effects of the pillar morphology (height and thickness) and the electrospinning parameters (applied voltage and working distance) on the overall shape and size of the cone structure, as well as the fiber alignment (Vong 2018).…”

Section: Fig 1 Typical Electrospinning Setupmentioning

confidence: 99%

Mathematical Modelling of Polymer Trajectory During Electrospinning

Ferouka¹,

Šušteršič²,

Živanović³

et al. 2018

JSSCM

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The most important characteristics of the electrospun fibers are their internal morphology and their diameter. They both depend on polymer's parameters, but also on the process parameters. The motivation for this research is therefore to simulate the jet during electrospinning and analyze the effects of some of the parameters on the jet (and implicitly on fibers), without the necessity to perform the experiments each time. The calculations of the polymer's behavior between the electrodes was based on the discrete model of Reneker. Thus, the jet was modeled as a system of beads connected by viscoelastic elements. The results were compared to the results obtained in the literature and showed good agreement. The results showed how the jet shape during electrospinning depends on each parameter. The ultimate goal was to establish the exact influence of the above-mentioned parameters on the fibers' diameter. This would allow to set rough values of electrospinning parameters, which could be further fine-tuned, in order to obtain the fibers with expected characteristics. The beneficial effect of such simulations are time gain, but also reduced material consumption, maintenance costs etc.

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Fabrication of radially aligned electrospun nanofibers in a three-dimensional conical shape

Cited by 6 publications

References 56 publications

Influence of nanofiber alignment on the release of a water-soluble drug from cellulose acetate nanofibers

Influence of nanofiber alignment on the release of a water-soluble drug from cellulose acetate nanofibers

Highly Aligned Electrospun Polymer Fibers Produced Using a Corrugated Static Collector

Mathematical Modelling of Polymer Trajectory During Electrospinning

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