Fabrication of polylactic acid (PLA)-based porous scaffold through the combination of traditional bio-fabrication and 3D printing technology for bone regeneration

Zhou, Xiaowen; Zhou, Gan; Junka, Radoslaw; Chang, N. A.; Anwar, Aneela; Wang, Haoyu; Yu, Xiaojun

doi:10.1016/j.colsurfb.2020.111420

Cited by 53 publications

(26 citation statements)

References 40 publications

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“…The mineral deposition is another key indicator of the osteogenic efficiency of rBMSCs, which was evaluated by ARS staining after 14 days of culture. [ 22 ] Figure 5c presents microscopic images of different samples stained with ARS. Compared with only little and pale red staining observed from PCL, a denser and brighter red staining appeared in the other three groups, indicating that the loading of bioactive components promoted the mineralization of the extracellular matrix, especially calcium‐binding peptides loading.…”

Section: Resultsmentioning

confidence: 99%

Hierarchical Nanostructured Electrospun Membrane with Periosteum‐Mimic Microenvironment for Enhanced Bone Regeneration

Liu

Shang

et al. 2021

Adv Healthcare Materials

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An ideal periosteum substitute should be able to mimic the periosteum microenvironment that continuously provides growth factors, recruits osteoblasts, and subsequent extracellular matrix (ECM) mineralization to accelerate bone regeneration. Here, a calcium‐binding peptide‐loaded poly(ε‐caprolactone) (PCL) electrospun membrane modified by the shish‐kebab structure that can mimic the periosteum microenvironment was developed as a bionic periosteum. The calcium‐binding peptide formed by the negatively charged heptaglutamate domain (E7) in the E7‐BMP‐2 with calcium ion in the tricalcium phosphate sol (TCP sol) through electrostatic chelation not only extended the release cycle of E7‐BMP‐2 but also promoted the biomineralization of the bionic periosteum. Cell experiments showed that the bionic periosteum could significantly improve the osteogenic differentiation of the rat‐bone marrow‐derived mesenchymal stem cells (rBMSCs) through both chemical composition and physical structure. The in vivo evaluation of the bionic periosteum confirmed the inherent osteogenesis of this periosteum microenvironment, which could promote the regeneration of vascularized bone tissue. Therefore, the hierarchical nanostructured electrospun membrane with periosteum‐mimic microenvironment is a promising periosteum substitute for the treatment of bone defects.

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Section: Resultsmentioning

confidence: 99%

Hierarchical Nanostructured Electrospun Membrane with Periosteum‐Mimic Microenvironment for Enhanced Bone Regeneration

Liu

Shang

et al. 2021

Adv Healthcare Materials

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“…Zimina et al report that the adhesion of MSC is about three times higher than that of the pure PLA sample mainly because the HA could increase the wettability of the polymeric biomaterial [70]. To scientifically support the PLA-HA scaffold, microanalysis [71] or 3D printing technology [72,73] has been recently studied.…”

Section: Poly(lactic Acid)mentioning

confidence: 99%

Biomaterial-Assisted Regenerative Medicine

Nii

Katayama

2021

IJMS

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This review aims to show case recent regenerative medicine based on biomaterial technologies. Regenerative medicine has arousing substantial interest throughout the world, with “The enhancement of cell activity” one of the essential concepts for the development of regenerative medicine. For example, drug research on drug screening is an important field of regenerative medicine, with the purpose of efficient evaluation of drug effects. It is crucial to enhance cell activity in the body for drug research because the difference in cell condition between in vitro and in vivo leads to a gap in drug evaluation. Biomaterial technology is essential for the further development of regenerative medicine because biomaterials effectively support cell culture or cell transplantation with high cell viability or activity. For example, biomaterial-based cell culture and drug screening could obtain information similar to preclinical or clinical studies. In the case of in vivo studies, biomaterials can assist cell activity, such as natural healing potential, leading to efficient tissue repair of damaged tissue. Therefore, regenerative medicine combined with biomaterials has been noted. For the research of biomaterial-based regenerative medicine, the research objective of regenerative medicine should link to the properties of the biomaterial used in the study. This review introduces regenerative medicine with biomaterial.

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“…Polylactic acid is made from renewable plant resources. Polylactic acid is a biodegradable polymer material with good biocompatibility, and it can be 3-D printed into any shape that is needed at the site of injury [ 151 ]. Patist et al [ 118 ] transplanted polylactic acid-containing brain-derived growth factors into the spinal cord of rats with thoracic cord transection.…”

Section: Biomaterials For Sustained Neurotrophic Factor Deliverymentioning

confidence: 99%

Sustained delivery of neurotrophic factors to treat spinal cord injury

Muheremu

Liang

et al. 2021

Translational Neuroscience

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Acute spinal cord injury (SCI) is a devastating condition that results in tremendous physical and psychological harm and a series of socioeconomic problems. Although neurons in the spinal cord need neurotrophic factors for their survival and development to reestablish their connections with their original targets, endogenous neurotrophic factors are scarce and the sustainable delivery of exogeneous neurotrophic factors is challenging. The widely studied neurotrophic factors such as brain-derived neurotrophic factor, neurotrophin-3, nerve growth factor, ciliary neurotrophic factor, basic fibroblast growth factor, and glial cell-derived neurotrophic factor have a relatively short cycle that is not sufficient enough for functionally significant neural regeneration after SCI. In the past decades, scholars have tried a variety of cellular and viral vehicles as well as tissue engineering scaffolds to safely and sustainably deliver those necessary neurotrophic factors to the injury site, and achieved satisfactory neural repair and functional recovery on many occasions. Here, we review the neurotrophic factors that have been used in trials to treat SCI, and vehicles that were commonly used for their sustained delivery.

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Fabrication of polylactic acid (PLA)-based porous scaffold through the combination of traditional bio-fabrication and 3D printing technology for bone regeneration

Cited by 53 publications

References 40 publications

Hierarchical Nanostructured Electrospun Membrane with Periosteum‐Mimic Microenvironment for Enhanced Bone Regeneration

Hierarchical Nanostructured Electrospun Membrane with Periosteum‐Mimic Microenvironment for Enhanced Bone Regeneration

Biomaterial-Assisted Regenerative Medicine

Sustained delivery of neurotrophic factors to treat spinal cord injury

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