Fabrication of poly-DL-lactide/polyethylene glycol scaffolds using the gas foaming technique

Ji, Chao; Annabi, Nasim; Hosseinkhani, M.R.; Sivaloganathan, Sobana; Dehghani, Fariba

doi:10.1016/j.actbio.2011.09.028

Cited by 103 publications

(57 citation statements)

References 61 publications

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“…The water uptake ratio of hybrid scaffolds ranged from 60.71 ± 5.1 to 122 ± 8.8 % when the weight ratio of PEGMA was increased from 10 to 50 wt%. Ji et al [32] found a similar trend in blending PLA/PEG scaffolds; the increased PEGMA weight ratio resulted in enhanced the water uptake capacity.…”

Section: Wettability and Water Absorption Capability Of Crosslinked Pmentioning

confidence: 72%

Fabrication of PU/PEGMA crosslinked hybrid scaffolds by in situ UV photopolymerization favoring human endothelial cells growth for vascular tissue engineering

Wang

Feng

et al. 2012

J Mater Sci: Mater Med

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Poly(ethylene glycol) methacrylate (PEGMA) was introduced into a polyurethane (PU) solution in order to prepare electrospun scaffold with improving the biocompatibility by electrospinning technology for potential application as small diameter vascular scaffolds. Crosslinked electrospun PU/PEGMA hybrid nanofibers were fabricated by a reactive electrospinning process with N,N'-methylenebisacrylamide as crosslinker and benzophenone as photoinitiator. The photoinduced polymerization and crosslinking reaction took place simultaneously during the electrospinning process. The electrospinning solutions with various weight ratios of PU/PEGMA were successfully electrospun. No significant difference in the scaffold morphology was found by SEM when PEGMA content was <20 wt%. The crosslinked fibrous scaffolds of PU/PEGMA exhibited higher mechanical strength than the pure PU scaffold. The hydrophilicity of scaffolds was controlled by varying the PU/PEGMA weight ratio. The tissue compatibility of electrospun nanofibrous scaffolds were tested using human umbilical vein endothelial cells (HUVECs). Cell morphology and cell proliferation were measured by SEM, fluorescence microscopy and thiazolyl blue assay (MTT) after 1, 3, 7 days of culture. The results indicated that the cell morphology and proliferation on the crosslinked PU/PEGMA scaffolds were better than that on the pure PU scaffold. Furthermore, the appropriate hydrophilic surface with water contact angle in the range of 55-75° was favorable of improvement the HUVECs adhesion and proliferation. Cells seeded on the crosslinked PU/PEGMA (80/20) scaffolds infiltrated into the scaffolds after 7 days of growth. These results indicated the crosslinked electrospun PU/PEGMA nanofibrous scaffolds were potential substitutes for artificial vascular scaffolds.

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Section: Wettability and Water Absorption Capability Of Crosslinked Pmentioning

confidence: 72%

Fabrication of PU/PEGMA crosslinked hybrid scaffolds by in situ UV photopolymerization favoring human endothelial cells growth for vascular tissue engineering

Wang

Feng

et al. 2012

J Mater Sci: Mater Med

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“…3 [40,45]. Figure 4 presents the potentiodynamic polarization curves of the AZ31 substrate, the samples coated with the ZnAl-LDH coating and the LDH/PLA composite coating.…”

Section: Resultsmentioning

confidence: 99%

Corrosion resistance of Zn–Al layered double hydroxide/poly(lactic acid) composite coating on magnesium alloy AZ31

Zeng

Liu

et al. 2015

Front. Mater. Sci.

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A Zn-Al layered double hydroxide (ZnAl-LDH) coating consisted of uniform hexagonal nano-plates was firstly synthesized by co-precipitation and hydrothermal treatment on the AZ31 alloy, and then a poly(lactic acid) (PLA) coating was sealed on the top layer of the ZnAl-LDH coating using vacuum freeze-drying. The characteristics of the ZnAl-LDH/PLA composite coatings were investigated by means of XRD, SEM, FTIR and EDS. The corrosion resistance of the coatings was assessed by potentiodynamic polarization and electrochemical impedance spectroscopy (EIS). The results showed that the ZnAl-LDH coating contained a compact inner layer and a porous outer layer, and the PLA coating with a strong adhesion to the porous outer layer can prolong the service life of the ZnAl-LDH coating. The excellent corrosion resistance of this composite coating can be attributable to its barrier function, ion-exchange and self-healing ability.

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“…However, using this method it is very difficult to obtain porous structures with pores of controlled size and interconnectivity. During gas foaming, large, closed pores can be created inside the polymer scaffold, which makes adequate cell proliferation improbable [144][145][146][147]. Scaffolds made by gas foaming are usually used for reconstruction of bone defects resulting from the treatment of bone fractures or tumours or for the reconstruction of bone tissues.…”

Section: Fabrication Of Porous Biopusmentioning

confidence: 99%

Synthesis and structure-property relationships of biodegradable polyurethanes

Pergal¹,

Blaban²

2017

Biodegradable Polymers: Recent Developments and New Perspectives

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Fabrication of poly-DL-lactide/polyethylene glycol scaffolds using the gas foaming technique

Cited by 103 publications

References 61 publications

Fabrication of PU/PEGMA crosslinked hybrid scaffolds by in situ UV photopolymerization favoring human endothelial cells growth for vascular tissue engineering

Fabrication of PU/PEGMA crosslinked hybrid scaffolds by in situ UV photopolymerization favoring human endothelial cells growth for vascular tissue engineering

Corrosion resistance of Zn–Al layered double hydroxide/poly(lactic acid) composite coating on magnesium alloy AZ31

Synthesis and structure-property relationships of biodegradable polyurethanes

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