Fabrication of pliable biodegradable polymer foams to engineer soft tissues

Wake, M. Conley

doi:10.1016/0963-6897(96)00025-5

Cited by 125 publications

(56 citation statements)

References 15 publications

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“…[16][17][18][19][20][21] There has been active research on creating porous structures from synthetic polymers [28][29][30][31][32][33][34] and biologically derivatized macromolecules such as collagen 35,36 and gelatin 37 to serve as scaffolding. For example, fibrous nonwoven fabrics made of synthetic polymers such as poly(L-lactic acid) 28,38,39 and SPU, [40][41][42] and open-cell structured porous foams, which are fabricated by a particle-leaching technique, 25,43,44 phase inversion technique, 33,45,46 or freeze-drying technique, [47][48][49][50] have been used as microporous scaffolds. On the other hand, the fibular structure of collagen lattices has been used with tissue-engineered devices such as hybrid vessels, 51-56 hybrid skins, [57][58][59] and hybrid livers.…”

Section: Discussionmentioning

confidence: 99%

Surface microarchitectural design in biomedical applications:In vivo analysis of tissue ingrowth in excimer laser-directed micropored scaffold for cardiovascular tissue engineering

Nakayama

Nishi

Ishibashi‐Ueda

et al. 2000

J. Biomed. Mater. Res.

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A micropatterned microporous segmented polyurethane film (20 x 12 mm in size, 30 micrometer thick) with four regions was prepared by excimer laser microprocessing to provide an in vivo model of transmural tissue ingrowth in an open cell-structured scaffold specially designed for cardiovascular tissue engineering. Three microporous regions had the same circular micropores (30 micrometer diameter) but different pore density arrangements (percentage of total pore area against unit area was 0.3%, 1.1%, and 4.5%), and the other region remained nonporous. The covered stent, prepared by wrapping the regionally different density-microporous film on an expandable metallic stent (approximately 3.1 mm in diameter), was delivered to the luminal surface of canine common carotid arteries and placed after expansion of the stent to a diameter of approximately 8 mm using a balloon catheter. At 4 weeks of implantation, all the covered stents (n = 10) were patent. The luminal surfaces of the covered stents were almost confluently endothelialized both in nonporous and microporous regions. Histological examination showed that the neointimal wall was formed by tissue ingrowth from host through micropores (transmural) and anastomotic sites. Thrombus formation occurred frequently in the lowest density porous region and nonporous region. With an increase in pore density, the thickness of the neointimal wall decreased. This study demonstrated how the micropore density of implanted devices influences tissue ingrowth in arterial implantation.

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Section: Discussionmentioning

confidence: 99%

Surface microarchitectural design in biomedical applications:In vivo analysis of tissue ingrowth in excimer laser-directed micropored scaffold for cardiovascular tissue engineering

Nakayama

Nishi

Ishibashi‐Ueda

et al. 2000

J. Biomed. Mater. Res.

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“…To meet such demands on the microstructure, several techniques have been investigated to fabricate the aforementioned PLGA into sponge-like scaffolds, including solvent-casting/particulate-leaching [9,10], phase separation [11][12][13], gas foaming [14,15] and so forth. Above all, the solvent-casting/particulate-leaching technique can create the desired pore size and porosity by incorporating the sieved NaCl particulates of the desired size and by varying the ratio of their salt particulates to the polymer, respectively.…”

Section: Introductionmentioning

confidence: 99%

Novel approach to fabricate keratin sponge scaffolds with controlled pore size and porosity

2004

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“…Numerous elaboration techniques and approaches to the development of three-dimensional scaffolds that combine biodegradability and bioactivity are currently under study (Coombes & Heckman 1992;Mikos et al 1993;Mooney et al 1996;Wake et al 1996). Each preparation technique confers particular and different structural characteristics to the scaffold.…”

Section: Third Generationmentioning

confidence: 99%

Biomaterials in orthopaedics

Navarro

Michiardi

Castaño

et al. 2008

J. R. Soc. Interface.

1,263

730

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At present, strong requirements in orthopaedics are still to be met, both in bone and joint substitution and in the repair and regeneration of bone defects. In this framework, tremendous advances in the biomaterials field have been made in the last 50 years where materials intended for biomedical purposes have evolved through three different generations, namely first generation (bioinert materials), second generation (bioactive and biodegradable materials) and third generation (materials designed to stimulate specific responses at the molecular level). In this review, the evolution of different metals, ceramics and polymers most commonly used in orthopaedic applications is discussed, as well as the different approaches used to fulfil the challenges faced by this medical field.

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Fabrication of pliable biodegradable polymer foams to engineer soft tissues

Cited by 125 publications

References 15 publications

Surface microarchitectural design in biomedical applications:In vivo analysis of tissue ingrowth in excimer laser-directed micropored scaffold for cardiovascular tissue engineering

Surface microarchitectural design in biomedical applications:In vivo analysis of tissue ingrowth in excimer laser-directed micropored scaffold for cardiovascular tissue engineering

Novel approach to fabricate keratin sponge scaffolds with controlled pore size and porosity

Biomaterials in orthopaedics

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