Fabrication of PEOT/PBT Nanofibers by Atmospheric Pressure Plasma Jet Treatment of Electrospinning Solutions for Tissue Engineering

Grande, Silvia; Cools, Pieter; Asadian, Mahtab; Guyse, Joachim F. R. Van; Onyshchenko, Iuliia; Morent, Rino; Hoogenboom, Richard

doi:10.1002/mabi.201800309

Cited by 18 publications

(11 citation statements)

References 47 publications

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“…[ 22,23 ] The resulting matrix can also be hydrophobic, which complicates cell adhesion, and therefore additional modification of the matrix is needed. [ 24–29 ] Simple methods for obtaining nanofibrillar structures mimicking the ECM is based on using of hydrogels. [ 30,31 ]…”

Section: Introductionmentioning

confidence: 99%

Nanofibrillar Hydrogels by Temperature Driven Self‐Assembly: New Structures for Cell Growth and Their Biological and Medical Implications

Abalymov

Santos

Meeren

et al. 2021

Adv Materials Inter

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Nanofibrillar structures are of importance in biomedicine, including lung, cardiovascular, liver, skin, neuroscience research, and tissue engineering. Developing advanced materials and interfaces should contribute to uncovering the mechanisms of diseases aiming to find cure. The similarity between the extracellular matrix (ECM) of soft tissue and hydrogels, characterized by a high water‐content viscoelastic polymeric fiber, has stimulated the development of hydrogels for biomedical applications. However, most hydrogels have a meshy structure resulting in poor cell adhesion properties. Here, fabrication of gellan gum (GG) hydrogels arranged by thermally driven self‐assembly into a network of nanofibers is reported. Mechanical properties of such nanofibrillar hydrogels are analyzed on micro‐ and macroscales. As a result, and in sharp contrast to commonly produced meshy GG hydrogels, the nanofiber‐based hydrogels facilitate the adherence and lead to proliferation of cells. This is assigned to microstructural rearrangements characterized by a changing density and pore size decrease, accompanied with a lower water content. Cell growth on such nanofibrillar structures is investigated for osteoblasts, which are chosen as a model system. The developed nanofibrous interfaces in this study are envisioned to be applicable for growing various types of cells and they should contribute to better understanding cell interactions with ECM.

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Section: Introductionmentioning

confidence: 99%

Nanofibrillar Hydrogels by Temperature Driven Self‐Assembly: New Structures for Cell Growth and Their Biological and Medical Implications

Abalymov

Santos

Meeren

et al. 2021

Adv Materials Inter

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show abstract

“…The percentage of O=C-O and COOH grew to 8.00% after the oxygen plasma treatment, which was more than three times higher than that of the helium plasma treatment (2.47%). This demonstrates that the C-C chemical bonds broke and reacted with the oxygen atoms under the action of plasma, resulting in the formation of new oxygen-containing polar groups [28]. The oxidation of the active substances during plasma treatment increases the number of hydrophilic groups, which is beneficial for the enhancement of the liquid absorption property of the textile pile debridement material.…”

Section: Xps Analysismentioning

confidence: 98%

A Textile Pile Debridement Material Consisting of Polyester Fibers for in Vitro Removal of Biofilm

Cheng

et al. 2020

Polymers

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Biofilms formed on skin wound lead to inflammation and a delay of healing. In the present work, a novel textile pile debridement material was prepared and treated by plasma. Samples before and after plasma treatment were characterized by a series of methods, including scanning electron microscopy (SEM), atomic force microscopy (AFM), X-ray photoelectron spectroscopy (XPS), and water uptake capacity. Besides, mechanical, coagulation, and in vitro biofilm removal performances of the textile pile debridement material were evaluated, with a medical gauze as a control. The results demonstrate that the plasma treatment produced corrosions and oxygen-containing polar groups on the fiber surface, offering an enhanced water uptake capacity of the textile pile debridement material. In addition, compressive tests certify the mechanical performances of the textile pile debridement material in both dry and wet conditions. The results from a kinetic clotting time test suggest a favorable ability to promote blood coagulation. Furthermore, the results of an MTT cell viability assay, SEM, and confocal laser scanning microscopy (CLSM) illustrate that the textile pile debridement material demonstrates a more superior in vitro biofilm removal performance than medical gauze. All of these characterizations suggest that the textile pile debridement material can offer a feasible application for clinical wound debridement.

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“…There is a lot of research investigating antimicrobial biomedical application [22][23][24][25][26][27]. Many researchers have studied the electro-spinning method for biomedical application [28][29][30][31][32][33][34][35][36][37]. Multi-level structured nano-fibers have been successfully developed via electro-spinning for different purposes through the use of such diverse materials as polyacrylic acid, silica nylon, polyacrylonitrile, SU-8 2100, polycarbonate, polybenzimidazole, polyurethane, polyethylene oxide, polystyrene, polyvinyl alcohol, gelatine, cellulose, chitosan, chitin, and carbon nano-materials [36][37][38].…”

Section: Electro-spinning For Biomedical Applicationsmentioning

confidence: 99%

Electrospun Nano-Fibers for Biomedical and Tissue Engineering Applications: A Comprehensive Review

et al. 2020

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Pharmaceutical nano-fibers have attracted widespread attention from researchers for reasons such as adaptability of the electro-spinning process and ease of production. As a flexible method for fabricating nano-fibers, electro-spinning is extensively used. An electro-spinning unit is composed of a pump or syringe, a high voltage current supplier, a metal plate collector and a spinneret. Optimization of the attained nano-fibers is undertaken through manipulation of the variables of the process and formulation, including concentration, viscosity, molecular mass, and physical phenomenon, as well as the environmental parameters including temperature and humidity. The nano-fibers achieved by electro-spinning can be utilized for drug loading. The mixing of two or more medicines can be performed via electro-spinning. Facilitation or inhibition of the burst release of a drug can be achieved by the use of the electro-spinning approach. This potential is anticipated to facilitate progression in applications of drug release modification and tissue engineering (TE). The present review aims to focus on electro-spinning, optimization parameters, pharmacological applications, biological characteristics, and in vivo analyses of the electro-spun nano-fibers. Furthermore, current developments and upcoming investigation directions are outlined for the advancement of electro-spun nano-fibers for TE. Moreover, the possible applications, complications and future developments of these nano-fibers are summarized in detail.

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Fabrication of PEOT/PBT Nanofibers by Atmospheric Pressure Plasma Jet Treatment of Electrospinning Solutions for Tissue Engineering

Cited by 18 publications

References 47 publications

Nanofibrillar Hydrogels by Temperature Driven Self‐Assembly: New Structures for Cell Growth and Their Biological and Medical Implications

Nanofibrillar Hydrogels by Temperature Driven Self‐Assembly: New Structures for Cell Growth and Their Biological and Medical Implications

A Textile Pile Debridement Material Consisting of Polyester Fibers for in Vitro Removal of Biofilm

Electrospun Nano-Fibers for Biomedical and Tissue Engineering Applications: A Comprehensive Review

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