Fabrication of paper-based microfluidic sensors by printing

Li, Xu; Tian, Junfei; Garnier, Gil; Shen, Wei

doi:10.1016/j.colsurfb.2009.12.023

Cited by 382 publications

(288 citation statements)

References 17 publications

Supporting

Mentioning

279

Contrasting

Unclassified

Order By: Relevance

“…The techniques so far reported include the use of photolithography, 7 inkjet printing, 8,9 printing of wax, 10,11 plasma oxidation, 12,13 laser-cutting, 14 and shaping, 15 each of which has its own merits and drawbacks. In general, the ideal technique should be as simple, cheap, and fast to implement as possible, and therefore multiple printing steps, the use of specialist chemicals, or complex post-processing procedures are to be avoided.…”

Section: Introductionmentioning

confidence: 99%

Laser-based patterning for fluidic devices in nitrocellulose

Katis

Eason

et al. 2015

Biomicrofluidics

View full text Add to dashboard Cite

In this report, we demonstrate a simple and low cost method that can be reproducibly used for fabrication of microfluidic devices in nitrocellulose. The fluidic patterns are created via a laser-based direct-write technique that induces polymerisation of a photo-polymer previously impregnated in the nitrocellulose. The resulting structures form hydrophobic barriers that extend through the thickness of the nitrocellulose and define an interconnected hydrophilic fluidic-flow pattern. Our experimental results show that using this method it is possible to achieve microfluidic channels with lateral dimensions of $100 lm using hydrophobic barriers that form the channel walls with dimensions of $60 lm; both of these values are considerably smaller than those that can be achieved with other current techniques used in the fabrication of nitrocellulose-based fluidic devices. A simple grid patterned nitrocellulose device was then used for the detection of C-reactive protein via a sandwich enzyme-linked immunosorbent assay, which served as a useful proof-of-principle experiment.

show abstract

Section: Introductionmentioning

confidence: 99%

Laser-based patterning for fluidic devices in nitrocellulose

Katis

Eason

et al. 2015

Biomicrofluidics

View full text Add to dashboard Cite

show abstract

“…As a result, lPADs have emerged as a promising platform for point-of-care analytical applications in clinical diagnostics, [1][2][3] food safety control, 4,5 and environmental testing. 6,7 Various techniques have been used to fabricate lPADs, including photolithography, 8,9 wax printing, [10][11][12] inkjet printing, [13][14][15] laser etching, 16,17 plasma treatment, 18 and use of metal/paper masks. [19][20][21][22][23] Each technique has particular advantages and drawbacks.…”

Section: Introductionmentioning

confidence: 99%

“…Prior to 2013, strong organic solvent or hydrophobic materials prepared in organic solvents were printed onto hydrophilic paper to create hydrophobic barriers. For example, toluene, 13 poly(dimethylsiloxane)-hexane solution, 14 and an alkenyl ketene dimer-heptane solution 15 have been used as printing inks for fabricating lPADs. Unfortunately, the cartridges and printers are easily attacked by organic solvents with strong solvation power (toluene, hexane, and heptane).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Defining microchannels and valves on a hydrophobic paper by low-cost inkjet printing of aqueous or weak organic solutions

Cai

Zhong

et al. 2015

Biomicrofluidics

View full text Add to dashboard Cite

We describe a simple and cost-effective strategy for rapid fabrication of microfluidic paper-based analytical devices and valves by inkjet printing. NaOH aqueous solution was printed onto a hydrophobic filter paper, which was previously obtained by soaking in a trimethoxyoctadecylsilane-heptane solution, allowing selective wet etching of hydrophobic cellulose to create hydrophilic-hydrophobic contrast with a relatively good resolution. Hexadecyltrimethylammonium bromide (CTMAB)-ethanol solution was printed onto hydrophobic paper to fabricate temperaturecontrolled valves. At low temperature, CTMAB deposited on the paper is insoluble in aqueous fluid, thus the paper remains hydrophobic. At high temperature, CTMAB becomes soluble so the CTMAB-deposited channel becomes hydrophilic, allowing the wicking of aqueous solution through the valve. We believe that this strategy will be very attractive for the development of simple micro analytical devices for point-of-care applications, including diagnostic testing, food safety control, and environmental monitoring. V C 2015 AIP Publishing LLC.

show abstract

“…There are several different fabrication techniques for paper-based sensing microfluidics reported in the literature [189][190][191][192]. However, for this review, only techniques utilized in combination with SERS-based detection towards POC will be discussed.…”

Section: Paper-based Sers Platformsmentioning

confidence: 99%

Surface enhanced Raman spectroscopy (SERS) for in vitro diagnostic testing at the point of care

et al. 2017

View full text Add to dashboard Cite

Point-of-care (POC) device development is a growing field that aims to develop low-cost, rapid, sensitive in-vitro diagnostic testing platforms that are portable, selfcontained, and can be used anywhere -from modern clinics to remote and low resource areas. In this review, surface enhanced Raman spectroscopy (SERS) is discussed as a solution to facilitating the translation of bioanalytical sensing to the POC. The potential for SERS to meet the widely accepted "ASSURED" (Affordable, Sensitive, Specific, Userfriendly, Rapid, Equipment-free, and Deliverable) criterion provided by the World Health Organization is discussed based on recent advances in SERS in vitro assay development. As SERS provides attractive characteristics for multiplexed sensing at low concentration limits with a high degree of specificity, it holds great promise for enhancing current efforts in rapid diagnostic testing. In outlining the progression of SERS techniques over the past years combined with recent developments in smart nanomaterials, high-throughput microfluidics, and low-cost paper diagnostics, an extensive number of new possibilities show potential for translating SERS biosensors to the POC.

show abstract

Fabrication of paper-based microfluidic sensors by printing

Cited by 382 publications

References 17 publications

Laser-based patterning for fluidic devices in nitrocellulose

Laser-based patterning for fluidic devices in nitrocellulose

Defining microchannels and valves on a hydrophobic paper by low-cost inkjet printing of aqueous or weak organic solutions

Surface enhanced Raman spectroscopy (SERS) for in vitro diagnostic testing at the point of care

Contact Info

Product

Resources

About