Fabrication of novel poly(lactic acid/caprolactone) bilayer membrane for GBR application

Abe, Gabriela L.; Sasaki, Junichi; Katata, Chihiro; Kohno, Tomoki; Tsuboi, Ririko; Kitagawa, Haruaki; Imazato, Satoshi

doi:10.1016/j.dental.2020.03.013

Cited by 47 publications

(68 citation statements)

References 42 publications

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“…Biodegradable aliphatic polyesters-such as polylactic acid (PLA), polyglycolic acid (PGA), polycaprolactone (PCL) and their copolymers (e.g. poly(lactic-co-glycolic acid) (PLGA) and poly(lactide-co-caprolactone) (PLCL))-are also used as barrier membranes [67,[95][96][97][98][99][100]. Aliphatic polyester membranes can be made to be reproducible because these workable materials are processed industrially.…”

Section: Biodegradable Synthetic Polymersmentioning

confidence: 99%

“…[ 97 ] and Abe et al. [ 100 ]. Copyright Elsevier B.V.…”

Section: Biodegradable Membranesmentioning

confidence: 99%

“…The biodegradability of aliphatic copolymer varies significantly depending on the types and ratio of polyester. The addition of PCL, which shows greater hydrophobicity and lower degradability than PLA and PGA, allows the lifetime of the membrane to be extended [ 100 ]. However, improving the mechanical properties using only biodegradable polyester is challenging, therefore these membranes tend to be applied for small tissue defects or in combination with bone substitute.…”

Section: Biodegradable Membranesmentioning

confidence: 99%

“…Recently, our group developed bilayer membranes based on PLGA or PLCL [ 97 , 100 ]. These membranes comprised a solid layer and a porous layer, which respectively provided barrier function and cell support ( Figure 1(B,C) ).…”

Section: Biodegradable Membranesmentioning

confidence: 99%

“…Furthermore, the PLCL membrane has a slower degradation rate than the other biodegradable polymers. Thus, PLCL bilayer membranes are considered promising biomaterials for GBR treatment ( Figure 1(D) ) [ 100 ].…”

Section: Biodegradable Membranesmentioning

confidence: 99%

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Barrier membranes for tissue regeneration in dentistry

Sasaki

Abe

et al. 2021

Biomaterial Investigations in Dentistry

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Background: In dentistry, barrier membranes are used for guided tissue regeneration (GTR) and guided bone regeneration (GBR). Various membranes are commercially available and extensive research and development of novel membranes have been conducted. In general, membranes are required to provide barrier function, biosafety, biocompatibility and appropriate mechanical properties. In addition, membranes are expected to be bioactive to promote tissue regeneration.Objectives: This review aims to organize the fundamental characteristics of the barrier membranes that are available and studied for dentistry, based on their components. Results: The principal components of barrier membranes are divided into nonbiodegradable and biodegradable materials. Nonbiodegradable membranes are manufactured from synthetic polymers, metals or composites of these materials. The first reported barrier membrane was made from expanded polytetrafluoroethylene (e-PTFE). Titanium has also been applied for dental regenerative therapy and shows favorable barrier function. Biodegradable membranes are mainly made from natural and synthetic polymers. Collagens are popular materials that are processed for clinical use by crosslinking. Aliphatic polyesters and their copolymers have been relatively recently introduced into GTR and GBR treatments. In addition, to improve the tissue regenerative function and mechanical strength of biodegradable membranes, inorganic materials such as calcium phosphate and bioactive glass have been incorporated at the research stage. Conclusions: Currently, there are still insufficient guidelines for barrier membrane choice in GTR and GBR, therefore dentists are required to understand the characteristics of barrier membranes.

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Section: Biodegradable Synthetic Polymersmentioning

confidence: 99%

“…[ 97 ] and Abe et al. [ 100 ]. Copyright Elsevier B.V.…”

Section: Biodegradable Membranesmentioning

confidence: 99%

Section: Biodegradable Membranesmentioning

confidence: 99%

Section: Biodegradable Membranesmentioning

confidence: 99%

Section: Biodegradable Membranesmentioning

confidence: 99%

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Barrier membranes for tissue regeneration in dentistry

Sasaki

Abe

et al. 2021

Biomaterial Investigations in Dentistry

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Synthesis of composite corn starch/hydroxyapatite nanoparticle biomembranes and their effect on mineralization by osteoblasts

Silva,

de Melo,

Sponchiado

et al. 2023

J of Applied Polymer Sci

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Bone defects and injuries are challenging issues in regenerative medicine. Guided bone regeneration (GBR) techniques use biomaterials as scaffolds to support the healing of damaged bone tissue. In this context, there is growing interest in developing new biomaterials with bioabsorbable and bioactive properties to increase GBR effectiveness. In this study, composite corn starch/hydroxyapatite nanoparticle (HAp) biomembranes were synthesized to achieve bioresorbable and bioactive properties compatible with applications in GBR. Starch is a renewable source and presents suitable rheological properties for membrane preparation; in turn, HAp is well known for its osteogenic properties. The biomembranes were prepared by solvent casting (5 wt% aqueous corn starch suspension containing different amounts of HAp (i.e., 0, 2, 5, and 10% of the corn starch weight), to give the membranes HAp_0%, HAp_2%, HAp_5%, and HAp_10%, respectively). The physicochemical and biological properties of the biomembranes were assessed. The concentrations of up to 10% of HAp were homogeneously dispersed in the composite biomembranes. HAp addition increased the biodegradability and the ability of the biomembranes to release Ca2+. The biomembranes containing HAp were more mechanically resistant and less flexible and were not toxic to osteoblasts. Moreover, compared to pure corn starch biomembranes, osteoblasts adhered better to the composite biomembranes. The higher the HAp content, the greater the mineralization promoted by osteoblasts on the composite biomembranes. HAp addition also resulted in composite biomembranes with better fracture healing efficiency in vitro. Therefore, composite corn starch/HAp biomembranes have excellent characteristics, including biodegradability, bioactivity, mechanical strength, and biocompatibility, for the development of new materials aimed at GBR.

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Asymmetric resorbable‐based dental barrier membrane for periodontal guided tissue regeneration and guided bone regeneration: A review

Bee

Hamid

2022

J Biomed Mater Res

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Guided tissue regeneration (GTR) and guided bone regeneration (GBR) are two common dental regenerative treatments targeted at reconstructing damaged periodontal tissue and bone caused by periodontitis. During GTR/GBR treatment, a barrier membrane is placed in the interface between the soft tissue and the periodontal defect to inhibit soft tissue ingrowth and creating a space for the infiltration of slowgrowing bone cells into the defect site. Recently, asymmetric resorbable-based barrier membrane has received a considerable attention as a new generation of GTR/GBR membrane. Despite numerous literatures about asymmetric-based membrane that had been published, there is lacks comprehensive review on asymmetric barrier membrane that particularly highlight the importance of membrane structure for periodontal regeneration. In this review, we systematically cover the latest development and advancement of various kinds of asymmetric barrier membranes used in periodontal GTR/GBR application. Herein, the ideal requirements for constructing a barrier membrane as well as the rationale behind the asymmetric design, are firstly presented. Various innovative methods used in fabricating asymmetric barrier membrane are being further discussed. Subsequently, the application and evaluation of various types of asymmetric barrier membrane used for GTR/GBR are compiled and extensively reviewed based on the recent literatures reported. Based on the existing gap in this field, the future research directions of asymmetric resorbable-based barrier membrane such as its combination potential with bone grafts, are also presented.

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Fabrication of novel poly(lactic acid/caprolactone) bilayer membrane for GBR application

Cited by 47 publications

References 42 publications

Barrier membranes for tissue regeneration in dentistry

Barrier membranes for tissue regeneration in dentistry

Synthesis of composite corn starch/hydroxyapatite nanoparticle biomembranes and their effect on mineralization by osteoblasts

Asymmetric resorbable‐based dental barrier membrane for periodontal guided tissue regeneration and guided bone regeneration: A review

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