Fabrication of novel PCL/PGS fibrous scaffold containing HA and GO through simultaneous electrospinning-electrospray technique

Nasari, Mina; Poursharifi, Nazanin; Fakhrali, Aref; Banitaba, Seyedeh Nooshin; Mohammadi, Sajjad; Semnani, Dariush

doi:10.1080/00914037.2022.2112678

Cited by 7 publications

(4 citation statements)

References 56 publications

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“…Meanwhile, the crucial roles of bones could be adversely influenced by injuries, fractures, diseases, accidents, and functional disorders. Correspondingly, various treatment strategies have been introduced, in which employing implants is considered a major great solution for bone tissue function [11]. In this era, material selection, matrix fabrication, and biological interactions are three factors affecting the final efficiency of engineered implants [12].…”

Section: Introductionmentioning

confidence: 99%

The Collagen-Based Scaffolds for Bone Regeneration: A Journey through Electrospun Composites Integrated with Organic and Inorganic Additives

et al. 2023

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Orthopedics has been identified as a major clinical medicine branch since the 18th century for musculoskeletal disease diagnosis and therapeutics. Along with technological progress, the surgical treatment of bone disorders became available in the 19th century, while its growth faced several obstacles due to a lack of proper biocompatible material and alternative structures. Therefore, tissue engineering has emerged as a key building block to overcome these challenges, providing the capability for bone growth, and fabricating scaffolds with enriched desirable cellular compatibility as well as mechanical properties. Among various structures, the electrospun layer has implied high porosity and fine pore sizes, and succeeded in cell growth and proliferation. Collagen nanofibers have represented a wide potential for mineralization, bone regeneration, and forming processes. Despite this, such scaffolds have accosted bone remodeling limitations due to inadequate osteoinductivity and mechanical strength. Hence, the tendency to fabricate efficient collagen-based nanofibrous layers enriched with organic and inorganic materials has been extensively declared. Embedding these materials leads to engineering a membrane with appropriate physical, degradability, and mechanical properties, as well as proper mineralization and biological activity required for better replicating the bone organ’s natural microenvironment. This paper highlighted a wide overview of the natural resources, electrospinning strategies, and collagen-based electrospun composites for bone regeneration. Accordingly, future prospects could be developed for generating novel 3D-scaffold formations, benefiting from organic and inorganic substances to boost the biological and mechanical properties, simultaneously.

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Section: Introductionmentioning

confidence: 99%

The Collagen-Based Scaffolds for Bone Regeneration: A Journey through Electrospun Composites Integrated with Organic and Inorganic Additives

et al. 2023

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“…5 Electrospinning is the most commonly used method for producing nanofibrous-based engineered scaffolds. fibers are widely used in various applications including actuators, 6−10 electrochemical structures for energy, 11,12 suture yarn, 13−15 drug delivery, 16−18 tissue engineering, 19,20 and biomedical application, etc. 21,22 Nanofibrous scaffolds are highly attractive due to their unique properties, such as high surface-to-volume ratio and porosity, that make them similar to the ECM of body tissues.…”

Section: Introductionmentioning

confidence: 99%

“…Electrospinning is the most commonly used method for producing nanofibrous-based engineered scaffolds. Nanofibers are widely used in various applications including actuators, − electrochemical structures for energy, , suture yarn, − drug delivery, − tissue engineering, , and biomedical application, etc. , …”

Section: Introductionmentioning

confidence: 99%

Electroconductive Nanofiber/Myocardium Gel Scaffolds Applicable for Myocardial Infarction Therapy

Fakhrali,

Tamimi,

Semnani

et al. 2024

ACS Appl. Polym. Mater.

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Myocardial infarction (MI) is a prevalent cause of mortality worldwide. In this study, a sandwich scaffold was prepared for MI therapy using two commonly used materials in the medical field, polyglycerol sebacate (PGS) and polycaprolactone (PCL), and a series of interrelated steps. The PGS/PCL nanofibers were coated with a conductive polymer, i.e., polypyrrole (PPy), and then embedded into a decellularized myocardium gel to form a 3D scaffold. Different quantitative and qualitative evaluation tests were performed, and their results were reported. Under optimal conditions for nanofiber production, the PGS/PCL/PPy nanofibers had an average diameter of 411 nm with electrical conductivity 0.00108 S cm–1. The hydrophilicity of the PGS/PCL layer did not significantly change after coating with PPy. The biodegradability test showed a reduction of 39% and 33% in weight for the uncoated and PPy-coated samples, respectively, after 24 weeks. The highest biocompatibility was observed in the sample synthesized with 0.05 M pyrrole. Histological assessments and DNA content tests validated the process of decellularization. The highest cell viability was observed in the scaffold containing a solubilized and decellularized myocardium gel (PGS/PCL/PPyA/DMG) with evenly distributed cells on the surface of the scaffolds. The highest cell infiltration and the highest percentage of expression of the specific cardiac proteins (Cx43, MHC, and cTnT) were also observed in the PGS/PCL/PPyA/DMG scaffold, which was attributed to the synergistic effect of PPy and decellularized myocardium gel (p-value <0.001).

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“…According to the literature, PCL has been identified as a great candidate for many biomedical applications, resulting from numerous appealing properties, including proper biodegradability and biocompatibility, nontoxicity, tailorable degradation kinetics, and appropriate solubility in common solvents (Cai et al, 2016;Cheng, Jun, Qin, & Lee, 2017;Ou et al, 2020). Hence, it has been widely applied in drug delivery systems, surgical sutures, scaffolds for tissue regeneration, and other long-term degradable implants (Malikmammadov, Tanir, Kiziltay, Hasirci, & Hasirci, 2018;Mochane, Motsoeneng, Sadiku, Mokhena, & Sefadi, 2019).…”

Section: Introductionmentioning

confidence: 99%

PCL/Fe3O4 magnetic electrospun yarn composites as a novel nanomaterial for biomedical applications

Gharehaghaji,

Sadrjahani,

Guravan

et al. 2023

Nanofab

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Magnetic composite structures were fabricated by embedding iron oxide nanoparticles (Fe3O4) into polycaprolactone (PCL) nanofibers through an electrospinning process. The PCL nanofibers incorporating 0.5 and 1 wt. % Fe3O4 were electrospun with various yarn and membrane architectures. SEM images of the fabricated fibers revealed diameter increment by raising the Fe3O4 proportion. Additionally, elongation at break, in tandem with the ultimate strength of the electrospun PCL yarn was improved by 63 and 67% through embedding 0.5 and 1 wt. % Fe3O4, respectively. The saturation magnetization results depended on the number of magnetic nanoparticles loaded in the electrospun fibers, as well as the architectural design of the electrospun fibers. The magnetic response of the fibrous yarns was enhanced by increasing the Fe3O4 mass fraction from 0.5 to 1 wt. %. The highest saturation magnetization of 5.38 emu/g was obtained for the electrospun yarn containing 1 wt. % Fe3O4, corroborating 13.6 times greater features than that of the fibrous membrane with a similar chemical composition. The obtained results implied that the as-spun fibrous yarn could be a great candidate as a surgical suture with the release capability of bioactive agents under a magnetic field.

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Fabrication of novel PCL/PGS fibrous scaffold containing HA and GO through simultaneous electrospinning-electrospray technique

Cited by 7 publications

References 56 publications

The Collagen-Based Scaffolds for Bone Regeneration: A Journey through Electrospun Composites Integrated with Organic and Inorganic Additives

The Collagen-Based Scaffolds for Bone Regeneration: A Journey through Electrospun Composites Integrated with Organic and Inorganic Additives

Electroconductive Nanofiber/Myocardium Gel Scaffolds Applicable for Myocardial Infarction Therapy

PCL/Fe3O4 magnetic electrospun yarn composites as a novel nanomaterial for biomedical applications

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