Fabrication of Non-woven Mats of Gelatin/Poly(<scp>l</scp>-lactic acid) Composites by Electrospinning and Their Application for Scaffold of Cell Proliferation

Moon, Young Sun; Uyama, Hiroshi; Înoue, Sachiko; Tabata, Yasuhiko

doi:10.1246/cl.2006.564

Cited by 19 publications

(9 citation statements)

References 18 publications

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“…Herein, we introduced poly (l-lactic acid) (PLLA) to blend with gelatin for fabrication of the composite nanofibers and expected the combination of gelatin and PLLA would provide the composite nanofiber mats with good cell adhesion and mechanical properties. This was also proved by Kim et al [15] and Moon et al [18] who successfully fabricated gelatin and PLLA blending nanofibers using TFE and HFIP as co-solvent respectively. Both of the cells they cultured were shown to grow and spread more actively on the composite nanofibers.…”

Section: Introductionmentioning

confidence: 54%

Preparation of fish gelatin and fish gelatin/poly(l-lactide) nanofibers by electrospinning

Liu

Guo

et al. 2010

International Journal of Biological Macromolecules

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Section: Introductionmentioning

confidence: 54%

Preparation of fish gelatin and fish gelatin/poly(l-lactide) nanofibers by electrospinning

Liu

Guo

et al. 2010

International Journal of Biological Macromolecules

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“…168,171 Cell proliferation is enhanced on fiber mats containing gelatin and PVA after crosslinking with glutaraldehyde to improve stability (Table 1). Additionally, gelatin can be electrospun with PLLA, 173,174 PCL, 175 PLGA, 176 and PANi. 177 Liu et al 183 (Fig.…”

Section: Gelatinmentioning

confidence: 99%

Electrosprayed nanoparticles and electrospun nanofibers based on natural materials: applications in tissue regeneration, drug delivery and pharmaceuticals

et al. 2015

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Nanotechnology refers to the fabrication, characterization, and application of substances in nanometer scale dimensions for various ends. The influence of nanotechnology on the healthcare industry is substantial, particularly in the areas of disease diagnosis and treatment. Recent investigations in nanotechnology for drug delivery and tissue engineering have delivered high-impact contributions in translational research, with associated pharmaceutical products and applications. Over the past decade, the synthesis of nanofibers or nanoparticles via electrostatic spinning or spraying, respectively, has emerged as an important nanostructuring methodology. This is due to both the versatility of the electrospinning/electrospraying process and the ensuing control of nanofiber/nanoparticle surface parameters. Electrosprayed nanoparticles and electrospun nanofibers are both employed as natural or synthetic carriers for the delivery of entrapped drugs, growth factors, health supplements, vitamins, and so on. The role of nanofiber/nanoparticle carriers is substantiated by the programmed, tailored, or targeted release of their contents in the guise of tissue engineering scaffolds or medical devices for drug delivery. This review focuses on the nanoformulation of natural materials via the electrospraying or electrospinning of nanoparticles or nanofibers for tissue engineering or drug delivery/pharmaceutical purposes. Here, we classify the natural materials with respect to their animal/plant origin and macrocyclic, small molecule or herbal active constituents, and further categorize the materials according to their proteinaceous or saccharide nature.

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“…For instance, Xin et al showed that PLGA nanofibrous scaffolds maintained hMSC phenotype in the absence of chemical signals to differentiate into osteogenic or chondrogenic lines 66. Furthermore, Li et al observed human embryonic palatal mesenchymal cell proliferation on crosslinked natural biopolymer nanofibers of gelatin, elastin, collagen, and tropoelastin,82 and Moon et al tested MSC on gelatin/PLA nanofibers,156 although no test for retention of pluripotency was noted in either case. Research on developing such plasticity‐preserving protocols is the subject of this section.…”

Section: Nerve Tissuementioning

confidence: 99%

Nanofibrous composites for tissue engineering applications

McCullen

Ramaswamy

Clarke

et al. 2009

WIREs Nanomed Nanobiotechnol

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Development of artificial matrices for tissue engineering is a crucial area of research in the field of regenerative medicine. Successful tissue scaffolds, in analogy with the natural mammalian extracellular matrix (ECM), are multi-component, fibrous, and on the nanoscale. In addition, to this key morphology, artificial scaffolds must have mechanical, chemical, surface, and electrical properties that match the ECM or basement membrane of the specific tissue desired. In particular, these material properties may vary significantly for the four primary tissues in the body: nerve, muscle, epithelial, and connective. In order to address this complex array of attributes with a polymeric material, a nanocomposite approach, employing a blend of materials, addition of a particle to enhance particular properties, or a surface treatment, is likely to be required. In this review, we examine nanocomposite approaches to address these diverse needs as a function of tissue type. The review is intended as a bridge between material scientists and biomedical researchers to give basic background information on tissue biology to the former, and on material processing approaches to the latter, in a general manner, and specifically review fibrous nanocomposite materials that have previously been used for cell studies, either in vivo or in vitro .

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Fabrication of Non-woven Mats of Gelatin/Poly(l-lactic acid) Composites by Electrospinning and Their Application for Scaffold of Cell Proliferation

Abstract: Nanofiber non-woven mats of gelatin/poly(l-lactic acid) composites were fabricated by electrospinning. The mechanical strength of the composite mats was much larger than that of the gelatin nanofiber mat. Mesenchymal stem cells adhered and proliferated well on the present composite mats.

Cited by 19 publications

References 18 publications

Preparation of fish gelatin and fish gelatin/poly(l-lactide) nanofibers by electrospinning

Preparation of fish gelatin and fish gelatin/poly(l-lactide) nanofibers by electrospinning

Electrosprayed nanoparticles and electrospun nanofibers based on natural materials: applications in tissue regeneration, drug delivery and pharmaceuticals

Nanofibrous composites for tissue engineering applications

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