Fabrication of Nanostructures Using Self-Assembled Peptides as Templates: The Diphenylalanine Case

Castillo-León, Jaime

doi:10.1016/b978-0-323-29642-7.00002-3

Cited by 2 publications

(1 citation statement)

References 26 publications

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“…Recently, many efforts have been made in the fabrication of bioactive and biocompatible nanoparticles for a variety of applications [31,32]. For example, DNA [33,34], peptides [35,36] and proteins [33] have been bioconjugated to nanoparticles with the use of the intermediate protecting agents of the nanoparticles or the linking agents [37]. Nowadays, research on direct conjugation of biocompatible agents and biomolecules to nanoparticles is accomplishable [38].…”

Section: Introductionmentioning

confidence: 99%

A rapid synthesis and antibacterial property of selenium nanoparticles using egg white lysozyme as a stabilizing agent

et al. 2019

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A simple method for the rapid synthesis of selenium nanoparticles (SeNPs) by the reduction of selenium dioxide using an aqueous egg white lysozyme solution (stabilizing agent) and ascorbic acid solution (reducing agent) has been described. The formation of SeNPs is assured by characterization with UV-Vis, FT-IR, XRD and morphological characters that were observed using TEM analyses. The absorbance of the SeNPs is found at 250 nm. The TEM images show that the SeNPs are uniform and in spherical shape of size 40-60 nm. The crystalline nature of SeNPs is assured by XRD analysis. The antibacterial property of synthesized SeNPs was tested against the pathogenic bacteria, i.e., Bacillus subtilis, Bacillus cereus, Escherichia coli, Staphylococcus pneumoniae, Proteus mirabilis and Klebsiella pneumoniae. SeNPs showed more antibacterial activity against B. subtilis (19 mm) and Streptococcus pneumoniae (15 mm) as compared with commercially available antibiotics such as streptomycin and erythromycin. The SeNPs synthesized via this process has proficient antimicrobial activity against pathogenic bacteria. SeNPs could play a significant role in pharmaceutical industries for the development of efficient antibiotic agents.

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Section: Introductionmentioning

confidence: 99%

A rapid synthesis and antibacterial property of selenium nanoparticles using egg white lysozyme as a stabilizing agent

et al. 2019

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Initial Aggregation and Ordering Mechanism of Diphenylalanine from Microsecond All-Atom Molecular Dynamics Simulations

2018

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Self-assembled diphenylalanine (FF) nanostructures have recently been demonstrated to be interesting materials for antibacterial and anticancer applications. These applications, among others, seek to take advantage of the high-order and resulting appealing physical properties of FF nanostructures by modifying the peptide in some way to achieve specific functionality. To rationally design modifications to the dipeptide that allow for this behavior, the driving forces of FF self-assembly must be understood. Molecular simulations have been utilized to assess these properties but have yielded conflicting conclusions due to inconsistencies in models chosen as well as the lack of quantitative analyses on the specific driving forces. Here, we present an all-atom explicit solvent molecular dynamics-based study on different length scales of FF aggregation. We utilize a free energy decomposition analysis as well as a dimer cluster analysis to identify the initial aggregation driving force to be FF intermolecular electrostatics, whereas solvent-mediated forces drive crystal growth. These data are consistent with the hypothesis that all hydrophobic dipeptides will have a similar initial aggregation mechanism until a critical aggregate size is reached, at which point crystallization occurs and subsequent crystal growth is dominated by solvent-mediated forces. We demonstrate that this proposed mechanism is testable by infrared spectroscopy focusing on the blueshift of the amide I peak as well as the ordering of the carboxylate peak.

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Fabrication of Nanostructures Using Self-Assembled Peptides as Templates: The Diphenylalanine Case

Cited by 2 publications

References 26 publications

A rapid synthesis and antibacterial property of selenium nanoparticles using egg white lysozyme as a stabilizing agent

A rapid synthesis and antibacterial property of selenium nanoparticles using egg white lysozyme as a stabilizing agent

Initial Aggregation and Ordering Mechanism of Diphenylalanine from Microsecond All-Atom Molecular Dynamics Simulations

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