Fabrication of Nanospheres and Vesicles as Drug Carriers by Self-Assembly of Alginate

Yu, Cui‐Yun; Jia, Lihui; Yin, Bing; Zhang, Xian‐Zheng; Cheng, Si‐Xue; Zhuo, Ren‐Xi

doi:10.1021/jp806540z

Cited by 59 publications

(47 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Since the drug with low molecular weight loaded in the polysaccharides can diffuse out quickly and easily, the polysaccharide-based drug delivery systems most commonly have a low encapsulation efficiency and fast drug release rate for the water-soluble drug with low molecular weight [34,35]. However, in our current work, the content of inorganic CaCO 3 is relatively high (54 wt%), resulting in a much higher encapsulation efficiency and slower drug release rate than the previously reported systems with polysaccharide as the main component [34]. …”

Section: Resultsmentioning

confidence: 99%

Fabrication of Alginate/Calcium Carbonate Hybrid Microparticles for Synergistic Drug Delivery

Peng¹,

Sun²,

Wang³

et al. 2015

Chemotherapy

View full text Add to dashboard Cite

A hybrid drug delivery system coloaded with different drugs for synergistic drug delivery was developed. Alginate/calcium carbonate (CaCO₃) hybrid microparticles (MPs) were fabricated via a facile coprecipitation method under mild conditions without using any organic solvent and surfactant. Due to the incorporation of negatively charged alginate chains onto the surface, the obtained hybrid MPs with spherical morphology showed good colloidal stability in an aqueous solution. An antitumor drug (doxorubicin, DOX) and a drug resistance reversal agent (verapamil, VP) were coloaded in the hybrid MPs simultaneously to obtain dual-drug-loaded MPs (DOX/VP/MP). Due to the presence of inorganic CaCO₃ (∼54 wt%), the drugs could be loaded in the hybrid MPs with high encapsulation efficiency and the drug release could be effectively sustained. The cell growth inhibition of the drug-loaded MPs was evaluated in HeLa cells. An in vitro study showed DOX/VP/MP exhibited higher cell growth inhibition as compared with DOX monodrug-loaded MPs (DOX/MP). These results suggest the hybrid MPs can potentially be used as a synergistic drug delivery platform for cancer chemotherapy.

show abstract

Section: Resultsmentioning

confidence: 99%

Fabrication of Alginate/Calcium Carbonate Hybrid Microparticles for Synergistic Drug Delivery

Peng¹,

Sun²,

Wang³

et al. 2015

Chemotherapy

View full text Add to dashboard Cite

show abstract

“…The particle sizes determined by TEM were smaller than that analyzed by dynamic light scattering (DLS) ( Table 1). It was due to the fact that the particles were in dry state determined by TEM, while DLS analysis process was performed in hydrated state [36,37].…”

Section: Synthesis and Characterization Of Ga-gel Conjugatesmentioning

confidence: 99%

Preparation and Evaluation of Doxorubicin-Loaded Micelles Based on Glycyrrhetinic Acid Modified Gelatin Conjugates for Targeting Hepatocellular Carcinoma

Fan

Yan

et al. 2018

Journal of Nanomaterials

View full text Add to dashboard Cite

Hepatocellular carcinoma (HCC) is one of the most prevalent fatal diseases and the incidence of HCC is increasing worldwide. Polymeric micelles with targeting groups have drawn great attention as carriers for drug delivery in HCC therapy. Herein, novel glycyrrhetinic acid modified gelatin (GA-GEL) conjugates with three substitution degrees were synthesized and characterized. Doxorubicin (DOX) was applied as a model drug. DOX-loaded GA-GEL (DOX/GA-GEL) micelles were prepared by an emulsionsolvent evaporation method. The mean diameters of DOX/GA-GEL micelles were in the range of 195-235 nm. The encapsulation efficiency of DOX/GA-GEL micelles was 63.6%-96.2%, and the loading content was 8.3%-12.5%. Drug release from DOX-loaded micelles exhibited a biphasic manner in phosphate buffer solution (PBS) at pH 7.4. DOX/GA-GEL could be efficiently accumulated into human liver cancer HepG2 cells. The IC 50 values of DOX/GA-GEL-2 and DOX⋅HCl in HepG2 cells were 0.33 and 0.66 g/mL, respectively. In vivo imaging analysis demonstrated that the fluorescence signals of DiR-labeled GA-GEL-2 micelles were mainly distributed in liver and H22 orthotopic tumor, indicating that GA-GEL had the liver-targeting activity. Compared to DOX⋅HCl, DOX/GA-GEL-2 exhibited better antitumor activity in H22 orthotopic mice. Therefore, these results indicated that GA-GEL could be used as carrier of hydrophobic drug for targeting HCC.

show abstract

“…The dried nanoparticles had a much smaller size compared with swollen nanoparticles in the aqueous phase; this was in good agreement with our previous results. 31,32 The differences in size between the dried and swollen nanoparticles may have resulted from the huge hydrodynamic volume of the nanoparticles. Figure 4(B) reveals the formation of large particles; this indicates that the GC-FUA nanoparticles aggregated easily in the aqueous phase.…”

Section: Synthesis and Characterization Of The Gc-fua Nanoparticlesmentioning

confidence: 99%

Fabrication of galactosylated chitosan–5‐fluorouracil acetic acid based nanoparticles for controlled drug delivery

Yang

et al. 2015

J of Applied Polymer Sci

Self Cite

View full text Add to dashboard Cite

In this study, a novel type of macromolecular prodrug, N-galactosylated chitosan (GC)25-fluorouracil acetic acid (FUA) conjugate based nanoparticles, was designed and synthesized as a carrier for hepatocellular carcinoma drug delivery. The GC-FUA nanoparticles were produced by an ionic crosslinking method based on the modified ionic gelation of tripolyphosphate with GC-FUA. The structure of the as-prepared GC-FUA was characterized by Fourier transform infrared and 1 H-NMR analyses. The average particle size of the GC-FUA nanoparticles was 160.1 nm, and their drug-loading content was 21.22 6 2.7% (n 5 3). In comparison with that of the freshly prepared nanoparticles, this value became larger after 7 days because of the aggregation of the GC-FUA nanoparticles. An in vitro drug-release study showed that the GC-FUA nanoparticles displayed a sustained-release profile compared to 5-fluorouracil-loaded GC nanoparticles. All of the results suggest that the GC-FUA nanoparticles may have great potential for antiliver-cancer applications.

show abstract

Fabrication of Nanospheres and Vesicles as Drug Carriers by Self-Assembly of Alginate

Cited by 59 publications

References 22 publications

Fabrication of Alginate/Calcium Carbonate Hybrid Microparticles for Synergistic Drug Delivery

Fabrication of Alginate/Calcium Carbonate Hybrid Microparticles for Synergistic Drug Delivery

Preparation and Evaluation of Doxorubicin-Loaded Micelles Based on Glycyrrhetinic Acid Modified Gelatin Conjugates for Targeting Hepatocellular Carcinoma

Fabrication of galactosylated chitosan–5‐fluorouracil acetic acid based nanoparticles for controlled drug delivery

Contact Info

Product

Resources

About