Fabrication of nanocoated fibers for self-diagnosis of bacterial vaginosis

Reukov, Vladimir; Vertegel, Alexey; Burtovyy, Oleksandr; Kornev, Konstantin G.; Luzinov, Igor; Miller, Paul

doi:10.1016/j.msec.2008.11.016

Cited by 20 publications

(10 citation statements)

References 21 publications

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“…[14,15] Other options for minimizing the excluded volume interactions, and thereby producing thicker (10-30 nm) grafted layers, are to conduct the grafting from a ''theta'' solvent [16] or from a concentrated polymer solution. [17,18] Synthesis of brushes on flat substrates, [12,[19][20][21] porous structures, [22,23] fibers/textiles, [24][25][26][27][28][29][30][31] and nanoparticles [28,32,33] using the ''grafting to'' procedures has been reported. In addition to synthesis of the uniform grafted layers the ''grafting to'' approach can be readily employed to synthesize patterned anchored polymer layers and brushes with variations in grafting density along a substrate ( Figure 1).…”

Section: Synthesis Of the Polymer Brushes Via The ''Grafting To'' Appmentioning

confidence: 99%

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Polymer Brushes by the “Grafting to” Method

Zdyrko

Luzinov

2011

Macromol. Rapid Commun.

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287

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This paper focuses on the attachment of densely grafted polymer layers (polymer brushes) to various inorganic and polymeric substrates by the "grafting to" method. A brief overview of synthesis of polymer brushes by the method is first provided, with emphasis on chemical approaches to polymer attachment. The second part of the paper covers the synthesis of polymer layers via a recently developed macromolecular anchoring layer approach. Several examples of application of the grafting technique are presented for generation of hydrophobic, hydrophilic, gradient, and switchable surfaces.

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Section: Synthesis Of the Polymer Brushes Via The ''Grafting To'' Appmentioning

confidence: 99%

“…[13, [23][24][25]31,112] The PGMA layers obtained were smooth and robust, suggesting that PGMA was chemically bonded to the surface. Subsequently, grafted layers were effectively generated from this PGMA platform using both ''grafting to'' and ''grafting from'' methods.…”

Section: Single Component Grafted Layersmentioning

confidence: 99%

Polymer Brushes by the “Grafting to” Method

Zdyrko

Luzinov

2011

Macromol. Rapid Commun.

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287

283

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“…Fabrication of these platforms involves a wide variety of techniques, including plotting [13,14], wax-printing [15][16][17][18][19], inkjet-printing [20,21], flexographic printing [22], computer-controlled knife cutting [23], laser cutting [24,25], vapor-phase polymer deposition [26][27][28], photolithography [29][30][31][32][33][34], spraying [35], electrospinning [5,6,36] and coating [37], among others (Table 1) [2,21]. Different aspects of paper-based bio-diagnostic devices, including fabrication strategies, applications for the recognition of various biomolecular entities, the storability as well as the marketability of the paper-based products have been extensively reviewed [2,3,21,[38][39][40][41].…”

Section: Introductionmentioning

confidence: 99%

“…Polymer-based fibers, in turn, have attracted a great deal of attention in medical diagnostics. Reukov et al, reported nano-coated nylon fibers, which were surface modified to possess positively charged characteristics for bacterial vaginosis detection and pregnancy diseases monitoring [36]. A triple-blend electrospun fiber mat has been used for the clinical diagnostic of colorectal cancer [50].…”

Section: Introductionmentioning

confidence: 99%

Paper and Fiber-Based Bio-Diagnostic Platforms: Current Challenges and Future Needs

2017

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Abstract:In this perspective article, some of the latest paper and fiber-based bio-analytical platforms are summarized, along with their fabrication strategies, the processing behind the product development, and the embedded systems in which paper or fiber materials were integrated. The article also reviews bio-recognition applications of paper/fiber-based devices, the detected analytes of interest, applied detection techniques, the related evaluation parameters, the type and duration of the assays, as well as the advantages and disadvantages of each technique. Moreover, some of the existing challenges of utilizing paper and/or fiber materials are discussed. These include control over the physical characteristics (porosity, permeability, wettability) and the chemical properties (surface functionality) of paper/fiber materials are discussed. Other aspects of the review focus on shelf life, the multi-functionality of the platforms, readout strategies, and other challenges that have to be addressed in order to obtain reliable detection outcomes.

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“…The development of this type of novel family of fiber-based materials requires understanding of the possible mechanisms for detection of a given liquid when it invades the pores of the fibrous material. In many applications, when dealing with a minute amount of liquid, fiber-based colorimetric biosensors seem to be the most popular [2][3][4][5]. However, in other situations, when the probe and sensor are hidden in an internal part of the material, making the color change impossible to detect, another mechanism of liquid detection is needed.…”

Section: Introductionmentioning

confidence: 99%