Fabrication of microscale medical devices by two-photon polymerization with multiple foci via a spatial light modulator

Gittard, Shaun D.; Nguyen, Alexander K.; Obata, Kotaro; Koroleva, Anastasia; Narayan, Roger J.; Chichkov, Boris N.

doi:10.1364/boe.2.003167

Cited by 172 publications

(108 citation statements)

References 58 publications

(110 reference statements)

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“…For reduction of the processing time, WOW-2PP can be combined with multi-focus structuring. 22,23 We hope that the demonstrated WOW-2PP technique can bring 2PP closer to applications.…”

Section: Resultsmentioning

confidence: 99%

High-aspect 3D two-photon polymerization structuring with widened objective working range (WOW-2PP)

et al. 2013

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We developed a novel two-photon polymerization (2PP) configuration for fabrication of high-aspect three-dimensional (3D) structures, with an overall height larger than working distance of the microscope objective used for laser beam focusing into a photosensitive material. This method is based on a modified optical 2PP setup, where a microscope objective (1003 high N.A.), immersion oil and cover glass can be moved together into the photosensitive material, resulting in an effective higher and wider objective working range (WOW-2PP). The proposed technique enables the fabrication of high-aspect structures with sub-micrometer process resolution. 3D structures with a height of 7 mm are demonstrated, which could hardly be built with the conventional 2PP set-up due to refractive index mismatch and laser beam disturbances.

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“…For reduction of the processing time, WOW-2PP can be combined with multi-focus structuring. 22,23 We hope that the demonstrated WOW-2PP technique can bring 2PP closer to applications.…”

Section: Resultsmentioning

confidence: 99%

High-aspect 3D two-photon polymerization structuring with widened objective working range (WOW-2PP)

et al. 2013

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“…These multiple beams were used to simultaneously produce multiple microstructures, which suggests it has a great potential to improve the efficiency of multi-photon polymerization. 63 …”

Section: D Structure Fabrication Using Multi-photon Polymerizationmentioning

confidence: 99%

Laser-assisted biofabrication in tissue engineering and regenerative medicine

et al. 2016

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Controlling the spatial arrangement of biomaterials and living cells provides the foundation for fabricating complex biological systems. Such level of spatial resolution (less than 10 lm) is difficult to be obtained through conventional cell processing techniques, which lack the precision, reproducibility, automation, and speed required for the rapid fabrication of engineered tissue constructs. Recently, laserassisted biofabrication techniques are being intensively developed with the use of computer-aided processes for patterning and assembling both living and nonliving materials with prescribed 2D or 3D organization. In this review, we discuss laser-assisted fabrication methods, including laser tweezers, multi-photon polymerization, laser-induced forward transfer (LIFT), matrix assisted pulsed laser evaporation (MAPLE), and laser ablation as well as their applications in biological science and biomedical engineering. These advanced technologies enable the precise manipulation of in vitro cellular microenvironments and the ability to engineer functional tissue constructs with high complexity and heterogeneity, which serve in regenerative medicine, pharmacology, and basic cell biology studies.

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“…It was called holographic femtosecond laser processing [2,3], and has the advantages of high-throughput pulsed irradiation and high energy-use efficiency of the pulse. The holographic femtosecond laser processing has been widely used in many applications, for example, optical waveguide fabrication [4], fabrication of volume phase gratings in polymers [5], surface structuring of silicon [6], twophoton polymerization [7], two-photon microscopy [8] and optical tweezers [9]. These applications have been mainly performed based on a holographic control of spatial phase of the light.…”

Section: Introductionmentioning

confidence: 99%

Holographic vector-wave femtosecond laser processing for fabrication of orientation-controlled nanostructures

Hasegawa

Hayasaki

2015

MATEC Web of Conferences

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Abstract. We demonstrated holographic vector-wave femtosecond laser processing system based on a holographic manipulation of the light including amplitude, phase and polarization. The system performs a high-throughput and flexible fabrication of orientation-controlled nanostructures applied to material surface modification for control of a tribology, wettability, light reflectance and retardance. In this experiment, a polarization characteristic of the laser processing system was experimentally verified. In addition, parallel fabrication of orientation-controlled nanostructures using multifocal vector beams was performed.

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Fabrication of microscale medical devices by two-photon polymerization with multiple foci via a spatial light modulator

Cited by 172 publications

References 58 publications

High-aspect 3D two-photon polymerization structuring with widened objective working range (WOW-2PP)

High-aspect 3D two-photon polymerization structuring with widened objective working range (WOW-2PP)

Laser-assisted biofabrication in tissue engineering and regenerative medicine

Holographic vector-wave femtosecond laser processing for fabrication of orientation-controlled nanostructures

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