Fabrication of microporous inorganic microneedles by centrifugal casting method for transdermal extraction and delivery

Gholami, Samira; Mohebi, Mohammad Masoud; Hajizadeh‐Saffar, Ensiyeh; Ghanian, Mohammad Hossein; Zarkesh, Ibrahim; Baharvand, Hossein

doi:10.1016/j.ijpharm.2018.12.089

Cited by 66 publications

(49 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Ceramic materials have suitable mechanical properties for MNs. Porous ceramic MNs were fabricated with two slurry-and resin-based formulations via cast into PDMS mould under centrifugal force, followed by sintering at high temperatures [131]. The casting method is an easy and applicable method for porous MNs fabrication.…”

Section: Casting Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Microneedle Arrays for Sampling and Sensing Dermal Interstitial Fluid

Kashaninejad¹,

Munaz²,

Moghadas³

et al. 2021

Preprint

View full text Add to dashboard Cite

Dermal interstitial fluid (ISF) is a novel source of biomarkers that can be considered as an alternative to blood sampling for disease diagnosis and treatment. Nevertheless, in vivo extraction and analysis of ISF are challenging. On the other hand, microneedle (MN) technology can address most of the challenges associated with dermal ISF extraction and is well-suited for long-term, continuous ISF monitoring as well as in situ detection. In this review, we first briefly summarise the different dermal ISF collection methods and compare them with MN methods. Next, we elaborate on the design considerations and biocompatibility of MNs. Subsequently, the fabrication technologies of various MNs used for dermal ISF extraction, including solid MNs, hollow MNs, porous MNs and hydrogel MNs, are thoroughly explained. In addition, different sensing mechanisms of ISF detection will be discussed in detail. Subsequently, we identify the challenges and propose the possible solutions associated with ISF extraction. A detailed investigation is provided for the transport and sampling mechanism of ISF in vivo. Also, the current in vitro skin model integrated with the MN arrays will be discussed. Finally, future directions to develop a point-of-care (POC) device to sample ISF are proposed.

show abstract

Section: Casting Methodsmentioning

confidence: 99%

“…Porous materials have a large volume of pores to extract fluid by capillary force. Casting technique [61,89,[129][130][131][132] and thermal drawing lithography [133] are two fabrication methods that were reported for porous MNs construction for ISF sampling. The porous structures were created via the leaching and sintering process.…”

Section: Porous Mnsmentioning

confidence: 99%

Microneedle Arrays for Sampling and Sensing Dermal Interstitial Fluid

Kashaninejad¹,

Munaz²,

Moghadas³

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

“…Moreover, by changing slurry components and sinter temperature, MN porosity can be adjusted to present different drug loading capacity and releasing speed [39]. Its biodegradable characteristic diminishes the risk of particle inflammation to a certain extent [61,62]. Meanwhile, a distinguished advantage of ceramic material is its stability in a high temperature and humidity environment [63].…”

Section: Ceramicsmentioning

confidence: 99%

Engineering Microneedles for Therapy and Diagnosis: A Survey

et al. 2020

View full text Add to dashboard Cite

Microneedle (MN) technology is a rising star in the point-of-care (POC) field, which has gained increasing attention from scientists and clinics. MN-based POC devices show great potential for detecting various analytes of clinical interests and transdermal drug delivery in a minimally invasive manner owing to MNs’ micro-size sharp tips and ease of use. This review aims to go through the recent achievements in MN-based devices by investigating the selection of materials, fabrication techniques, classification, and application, respectively. We further highlight critical aspects of MN platforms for transdermal biofluids extraction, diagnosis, and drug delivery assisted disease therapy. Moreover, multifunctional MNs for stimulus-responsive drug delivery systems were discussed, which show incredible potential for accurate and efficient disease treatment in dynamic environments for a long period of time. In addition, we also discuss the remaining challenges and emerging trend of MN-based POC devices from the bench to the bedside.

show abstract

“…Based on the aforementioned manufacturing techniques, diverse raw materials (such as metals, 47,48 silicon, 49,50 ceramics, 51,52 and polymers [53][54][55] ) have been utilized to fabricate MN patches containing arrays of solid, 56,57 porous, 58,59 or hollow 60,61 needles. Samant et al investigated the effects of the size of MNs on pressure-driven extraction of ISF, and the results showed a decreased volume of collected ISF with the increase of MN length between 250 mm and 750 mm.…”

Section: Design and Fabrication Strategies Of Mnsmentioning

confidence: 99%