Fabrication of microfluidic chips using controlled dissolution of<scp>3D</scp>printed scaffolds

Alkayyali, Tartela; Ahmadi, Ali

doi:10.1002/app.49524

Cited by 12 publications

(7 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Due to the directional deposition of the material, the samples exhibit anisotropic behavior. This has been verified by several authors who have examined the mechanical properties of FFF parts 9,10 …”

Section: Introductionsupporting

confidence: 57%

Experimental optimization of process parameters on mechanical properties and the layers adhesion of 3D printed parts

Ali

Khlif

Hammami

et al. 2021

J of Applied Polymer Sci

View full text Add to dashboard Cite

Additive manufacturing by fused filament fabrication provides an innovative manufacturing process for new design vision and complex geometry components. This study aims to establish the relationships between the process parameters and the mechanical properties of 3D printed parts using Taguchi design of experiment. The proposed method also enables the study of the filling orientation effects on the cohesion of the printed layers and the overall fracture behavior. We reviewed and optimized the effects of the critical parameters of process such as the layer thickness, the temperature, the print speed, and the filling orientation on Young's modulus and tensile strength. Then the effect of raster angle on the cohesion between the printed layers, as well as the failure modes were analyzed. The results show that the layer thickness and the filling angle are more influential on the mechanical properties. An analysis of the fracture surfaces of tensile specimens was also performed and it indicated a fracture following the filling direction. Furthermore, the fill angle 0/90° shows the best adhesion between the printed layers.

show abstract

Section: Introductionsupporting

confidence: 57%

Experimental optimization of process parameters on mechanical properties and the layers adhesion of 3D printed parts

Ali

Khlif

Hammami

et al. 2021

J of Applied Polymer Sci

View full text Add to dashboard Cite

show abstract

“…As alternative to printing enclosed microvoids, an FFF printed structure was used as a sacrificial mold for casting Poly(dimethylsiloxane). 52 Using this approach, however, the obtained channel size remained around 500 μm.…”

Section: ■ Printing Microfluidic Structuresmentioning

confidence: 95%

3D Printing: An Alternative Microfabrication Approach with Unprecedented Opportunities in Design

et al. 2020

View full text Add to dashboard Cite

In the past decade, 3D printing technologies have been adopted for the fabrication of microfluidic devices. Extrusionbased approaches including fused filament fabrication (FFF), jetting technologies including inkjet 3D printing, and vat photopolymerization techniques including stereolithography (SLA) and digital light projection (DLP) are the 3D printing methods most frequently adopted by the microfluidic community. Each printing technique has merits toward the fabrication of microfluidic devices. Inkjet printing offers a good selection of materials and multimaterial printing, and the large build space provides manufacturing throughput, while FFF offers a great selection of materials and multimaterial printing but at lower throughput compared to inkjet 3D printing. Technical and material developments adopted from adjacent research fields and developed by the microfluidic community underpin the printing of sub-100 μm enclosed microchannels by DLP, but challenges remain in multimaterial printing throughput. With the feasibility of 3D printed microfluidics established, we look ahead at trends in 3D printing to gain insights toward the future of this technology beyond the sole prism of being an alternative fabrication approach. A shift in emphasis from using 3D printing for prototyping, to mimic conventionally manufactured outputs, toward integrated approaches from a design perspective is critically developed.

show abstract

“…In addition, the sacrificial-mold method allows for fully 3D structures, only limited by the printing technology and the possibility to dissolve the scaffold. Both methods are successfully being used with molds produced by FDM printers, because of the availability of printing materials that are suitable for dissolving 20 – 22 . However, FDM printers are limited in how complex 3D structures they can produce, and achieving the smooth surface finish needed to validate flow simulations is difficult.…”

Section: Introductionmentioning

confidence: 99%

Patient-specific brain arteries molded as a flexible phantom model using 3D printed water-soluble resin

Nilsson

Holmgren

Holmlund

et al. 2022

Sci Rep

View full text Add to dashboard Cite

Visualizing medical images from patients as physical 3D models (phantom models) have many roles in the medical field, from education to preclinical preparation and clinical research. However, current phantom models are generally generic, expensive, and time-consuming to fabricate. Thus, there is a need for a cost- and time-efficient pipeline from medical imaging to patient-specific phantom models. In this work, we present a method for creating complex 3D sacrificial molds using an off-the-shelf water-soluble resin and a low-cost desktop 3D printer. This enables us to recreate parts of the cerebral arterial tree as a full-scale phantom model ($$10\times 6\times 4$$ 10 × 6 × 4 cm) in transparent silicone rubber (polydimethylsiloxane, PDMS) from computed tomography angiography images (CTA). We analyzed the model with magnetic resonance imaging (MRI) and compared it with the patient data. The results show good agreement and smooth surfaces for the arteries. We also evaluate our method by looking at its capability to reproduce 1 mm channels and sharp corners. We found that round shapes are well reproduced, whereas sharp features show some divergence. Our method can fabricate a patient-specific phantom model with less than 2 h of total labor time and at a low fabrication cost.

show abstract

Fabrication of microfluidic chips using controlled dissolution of3Dprinted scaffolds

Cited by 12 publications

References 42 publications

Experimental optimization of process parameters on mechanical properties and the layers adhesion of 3D printed parts

Experimental optimization of process parameters on mechanical properties and the layers adhesion of 3D printed parts

3D Printing: An Alternative Microfabrication Approach with Unprecedented Opportunities in Design

Patient-specific brain arteries molded as a flexible phantom model using 3D printed water-soluble resin

Contact Info

Product

Resources

About