Fabrication of magnetic nanocomposite as responsive drug delivery vehicle for cervical cancer therapy

Abstract

The development of carriers for drug delivery faces significant challenges from a therapeutic perspective. The present study presents an innovative nanocarrier based on combination of functionalized magnetic nanocomposite nano‐chitosan and cisplatin. Hydrophobic drugs such as cisplatin could be delivered using magnetic nanoparticles modified with biocompatible copolymers. This study aimed to determine the antitumor effects of free cisplatin enhancement in cervical cancer cells using cisplatin‐encapsulated Fe3O4@SiO2@N‐Chit‐FA. An additional layer of nanochitosan was coated on top of the magnetic nanocomposite to increase its stability in aqueous solutions. Biocompatibility and cytotoxicity of Fe3O4@SiO2@N‐Chit‐FA‐cis complex were evaluated against the cervical cancer animal model in C57BL6 mice. An external magnetic field was used to test the in‐vivo uptake and distribution of Fe3O4@SiO2 @N‐Chit‐FA‐cis in tumor cells. The results showed that the released drug would induce its effects on a specific target area when an external magnetic field was applied, and Fe3O4@SiO2@N‐Chit‐FA‐cis can suppress tumor growth more than cisplatin alone via induction of tumor necrosis. Overall, Fe3O4@SiO2@N‐Chit‐FA nanocomposites hold great potential for use in targeted nanomedicine to deliver bio‐functional molecules.

MXenes-polymer nanocomposites for biomedical applications: fundamentals and future perspectives

“…In electro-responsive drug release, the electrically conductive MXene by using the external electric field ( Zavahir et al, 2020 ). Similarly, the external magnetic field plays the same role in magnetic-responsive drug release ( Darroudi et al, 2023 ).The light-responsive molecules like photochromic compounds stimulated by light of a certain wavelength create structural changes in MXene or its surroundings for light-responsive drug release ( Zavahir et al, 2020 ). In case of temperature-responsive drug release, MXene nanosheets into a polymer matrix with a lower critical solution temperature (LCST), the drug release can be triggered by changes in temperature above or below the LCST can be utilized ( Karimi et al, 2016 ).…”

How Magnetic Composites are Effective Anticancer Therapeutics? A Comprehensive Review of the Literature

“…This is due to their excellent structural properties including pH, thermo, and magneto-responsive along with high magnetization, colloidal stability, drug-conjugation, biodegradability, and biocompatibility manner. 4,17,18 In this manner, MNCs have been studied for MHT, [19][20][21][22][23] targeted drug delivery, 24,25 bioseparation, 26,27 biosensing, 28,29 cell labeling, 30 targeting and immunoassays, [31][32][33] targeted cancer therapy, 34,35 and magnetic resonance imaging (MRI). [36][37][38][39] In an ideal scenario of chemothermotherapy using MHT, alternating magnetic field (AMF) can generate local heating onto MNCs and also tumor cells for thermal treatment and also a heat-dependent release of drug to sensitize cancer cells.…”

“…This is due to their excellent structural properties including pH, thermo, and magneto-responsive along with high magnetization, colloidal stability, drug-conjugation, biodegradability, and biocompatibility manner. 4 , 17 , 18 In this manner, MNCs have been studied for MHT, 19–23 targeted drug delivery, 24 , 25 bioseparation, 26 , 27 biosensing, 28 , 29 cell labeling, 30 targeting and immunoassays, 31–33 targeted cancer therapy, 34 , 35 and magnetic resonance imaging (MRI). 36–39 …”