Fabrication of magnesium oxide nanoparticles by solvent alteration and their bactericidal applications

Bhattacharya, Pushpak; Swain, Sarpras; Giri, Lopamudra; Neogi, Sudarsan

doi:10.1039/c9tb00782b

Cited by 47 publications

(26 citation statements)

References 59 publications

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“…In these, Mn 3 O 4 nanoparticles have encouraged abundant attention owing to their distinctive structural and electronic features with exclusive ion exchange, catalysis, molecular adsorption, magnetic and electrochemical properties. Manganese is deliberated a vital constituent in metabolism has been well controlled by biological systems and Mn 3 O 4 NPs display greater biological properties and low toxicity ( Bhattacharya et al, 2019 , Khan et al, 2016 ). Accordingly, Mn 3 O 4 NPs have been competently examined as prospective antibacterial systems because of their synergistic performance.…”

Section: Introductionmentioning

confidence: 99%

Mn3O4 nanoparticles: Synthesis, characterization and their antimicrobial and anticancer activity against A549 and MCF-7 cell lines

Shaik

Syed

Adil

et al. 2021

Saudi Journal of Biological Sciences

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Due to their inexpensive and eco-friendly nature, and existence of manganese in various oxidation states and their natural abundance have attained significant attention for the formation of Mn 3 O 4 nanoparticles (Mn 3 O 4 NPs). Herein, we report the preparation of Mn 3 O 4 nanoparticles using manganese nitrate as a precursor material by utilization of a precipitation technique. The as-prepared Mn 3 O 4 nanoparticles (Mn 3 O 4 NPs) were characterized by using X-ray powder diffraction (XRD), UV–Visible spectroscopy (UV–Vis), High-Resolution Transmission electron microscopy (HRTEM), Field emission scanning electron microscopy (FESEM), Thermal gravimetric analysis (TGA) and Fourier-transform infrared spectroscopy (FT-IR). The antimicrobial properties of the as-synthesized Mn 3 O 4 nanoparticles were investigated against numerous bacterial and fungal strains including S. aureus, E. coli , B. subtilis, P. aeruginosa, A. flavus and C. albicans . The Mn 3 O 4 NPs inhibited the growth of S. aureus with a minimum inhibitory concentration (MIC) of 40 μg/ml and C. albicans with a MIC of 15 μg/ml. Furthermore, the Mn 3 O 4 NPs anti-cancer activity was examined using MTT essay against A549 lung and MCF-7 breast cancer cell lines. The Mn 3 O 4 NPs revealed significant activity against the examined cancer cell lines A549 and MCF-7. The IC 50 values of Mn 3 O 4 NPs with A549 cell line was found at concentration of 98 µg/mL and MCF-7 cell line was found at concentration of 25 µg/mL.

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Section: Introductionmentioning

confidence: 99%

Mn3O4 nanoparticles: Synthesis, characterization and their antimicrobial and anticancer activity against A549 and MCF-7 cell lines

Shaik

Syed

Adil

et al. 2021

Saudi Journal of Biological Sciences

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“…demonstrated resistance to commercially available antimicrobial agents at an increasing rate and has become a global threat especially in developing countries. To obviate this, nanoparticles were recently used which provide a new strategy for the development of new antimicrobial agents [2,[19][20][21][22]. Among noble metals, silver shows disinfecting, antimicrobial properties and tremendous medicinal value [7,23].…”

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confidence: 99%

The synergistic effect of biosynthesized silver nanoparticles from a combined extract of parsley, corn silk, and gum arabic: in vivo antioxidant, anti-inflammatory and antimicrobial activities

Helmy

El-Shazly

Seleem

et al. 2020

Mater. Res. Express

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Microbial resistance, oxidative stress, and inflammatory conditions are among the leading causes of death worldwide. In the current work, silver nanoparticles (AgNPs) were biosynthesized using the aqueous extracts of parsley, corn silk (CS), gum Arabic (GA) or combination of the three extracts. The formed nanoparticles were characterized using three techniques including transmission electron microscopy (TEM), UV-visible spectrophotometer and Fourier-transform infrared spectroscopy (FTIR). The antioxidant, anti-inflammatory, and antimicrobial activities were tested for the formed nanoparticles, the aqueous extracts of each of the three plants and their combination. Oxidative stress was induced by alloxan which promoted the development of diabetes mellitus in rats. Inflammation was induced by injecting carrageenan in rats' paws. Pathogenic microorganisms causing serious urinary tract infection (UTI) were selected for the antimicrobial assay. All aqueous extracts and the biosynthesized AgNPs showed variable degrees of antioxidant, anti-inflammatory and antimicrobial activities, however, the AgNPs biosynthesized by the combination of the three aqueous extracts was the most effective one. LC/MS was done to identify the compounds present in the crude extracts that may be responsible for the observed biological activities. LC/MS resulted in the identification of 13 compounds. Docking experiments on COX-1 (cyclooxygenase-1) and COX-2 (cyclooxygenase-2) were performed to determine the compounds responsible for the antiinflammatory activity of the extracts. The results showed that silver nanoparticles synthesized by the combination of the three aqueous extracts are considered promising candidates for the development of antioxidant, anti-inflammatory and antimicrobial agents. photochemical [10], electrochemical [7, 11], reverse micelle [12], thermal decomposition [13], radiation [7,14] and microwave-assisted [7] methods. Most of these methods require the use of hazardous chemicals and high energy for the preparation of nanoparticles. Biological synthesis of nanoparticles involves the use of natural materials such as plants, bacteria, fungi [1,5,15]. The use of plants for the synthesis of nanoparticles have an advantage over other biological methods as it does not involve the use of cell culture, and does not need longer incubation time required for the reduction of metal ions [16,17]. Plants are known to contain various secondary metabolites such as alkaloids, terpenoids, flavonoids and tannins which provide suitable reducing and surface agents for the nanoparticle synthesis and stabilization. Biopolymers such as cellulose, chitosan, alginate, dextran and tree gums are another family of natural sources which were used for the reduction and stabilization of nanoparticles [17,18].Recently, pathogenic bacteria and fungi such as Staphylococci spp., Enterococci spp., Klebsiella pneumoniae, and Pseudomonas spp. demonstrated resistance to commercially available antimicrobial agents at an increasing rate and has become a global thr...

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“…Through passing years researchers have synthesized magnesium oxide nanoparticle and studied them in detail for their properties and applications [40][41][42][43][44][45][46]. Many research groups have reviewed their properties, synthesis, and applications.…”

Section: Synthesismentioning

confidence: 99%

“…This method was brought into sight to increase the synthesis of magnesium oxide nanoparticles via green synthesis method to not only reduce the use of chemicals but also because of its costefficient nature [43]. With loads of applications mentioned above, this metal oxide nanoparticle still possesses many more in this domain as magnesium nanoparticles are used in wound healing because of its ability to aid fibroblast adhesion after skin injury and as far as skin injury is concerned magnesium oxide nanoparticles should be synthesized in ethyl alcohol because they withhold excellent biocompatibility and antibacterial property [109,110]. The information provided by S. Hayat et al, depicts that magnesium oxide nanoparticles are effective and reliable antibiofilm agents that can inhibit adhesion, biofilm formation and remove the preformed biofilms of multidrug-resistant bacteria [111].…”

Section: Therapeutics Based On Magnesium Oxide Nanoparticlesmentioning

confidence: 99%

“…In couple of cases toxicity of magnesium oxide nanoparticles have been proven where V.B. Shah et al reported the adverse effects of magnesium oxide nanoparticles leading to cellular apoptosis on the embryos of zebrafish [110,124] and it's also emphasized that magnesium oxide nanoparticles, in significant amount, when injected in Wistar rats resulted in alteration of biochemical pathways and DNA damage. Solely, not only magnesium oxide nanoparticles but TiO2 and cerium oxide nanoparticles along several others in the queue have been reported to cause toxicity in either plants or animals [112].…”

Section: Nanotoxicitymentioning

confidence: 99%

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Recent Applications of Magnesium Oxide (MgO) Nanoparticles in various domains

Fernandes¹,

Singh²,

Sarkar³

et al. 2020

Adv. Mater. Lett.

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Fabrication of magnesium oxide nanoparticles by solvent alteration and their bactericidal applications

Abstract: MgO nanoparticles are synthesized using water, ethanol and aqueous CTAB solution. The nanoparticles synthesized in ethanol exhibited smallest size, maximum reactive oxygen species generation and maximum antibacterial ability, and low haemolysis.

Cited by 47 publications

References 59 publications

Mn3O4 nanoparticles: Synthesis, characterization and their antimicrobial and anticancer activity against A549 and MCF-7 cell lines

Mn3O4 nanoparticles: Synthesis, characterization and their antimicrobial and anticancer activity against A549 and MCF-7 cell lines

The synergistic effect of biosynthesized silver nanoparticles from a combined extract of parsley, corn silk, and gum arabic: in vivo antioxidant, anti-inflammatory and antimicrobial activities

Recent Applications of Magnesium Oxide (MgO) Nanoparticles in various domains

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