Fabrication of Konjac glucomannan-based composite hydrogel crosslinked by calcium hydroxide for promising lacrimal plugging purpose

Xu, Ningxia; Yang, Hua; Wei, Rong Hui; Pan, Shi-Yin; Huang, Saipeng; Xiao, Xianghua; Wen, Huiyun; Wang, Xue

doi:10.1016/j.ijbiomac.2019.01.069

Cited by 20 publications

(8 citation statements)

References 43 publications

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“…The cross-linking hydrogel has low toxicity, high water-retention capacity, multifunctional usefulness, and excellent biocompatibility [ 35 , 36 ], and has been applied in several biomedical research fields such as drug release [ 37 , 38 ], cell culture [ 39 ], tissue regeneration [ 40 – 42 ], 3D bioprinting [ 43 ], and prevention of postoperative intra-abdominal adhesion [ 44 ]. In the field of ophthalmology, cross-linking hydrogel has been used in tissue engineering, including corneal transplant [ 45 , 46 ] and retinal progenitor cell transplantation [ 47 ], drug delivery systems for multiple eye diseases such as glaucoma [ 48 ] and uveitis treatment [ 49 ], treatment of ocular surface [ 50 ] and lacrimal diseases [ 51 ], and substitution of the vitreous body [ 52 , 53 ], showing great potential. It was reported that a hydrogel based on thiol-modified derivatives of hyaluronic acid can become gelated at room temperature and be modulated in both gel compliance and gelation time by adjusting the ratio of its components [ 54 , 55 ].…”

Section: Discussionmentioning

confidence: 99%

Efficacy, Drug Sensitivity, and Safety of a Chronic Ocular Hypertension Rat Model Established Using a Single Intracameral Injection of Hydrogel into the Anterior Chamber

Huang

Chen

et al. 2020

Med Sci Monit

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Section: Discussionmentioning

confidence: 99%

Efficacy, Drug Sensitivity, and Safety of a Chronic Ocular Hypertension Rat Model Established Using a Single Intracameral Injection of Hydrogel into the Anterior Chamber

Huang

Chen

et al. 2020

Med Sci Monit

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“…SA powder (0.8 g) and KGM powder (0.4 g) were mixed with a 350 r/min stirring in a water bath at 40 °C. 60 The obtained homogeneous sol was poured into a template with a diameter of 20 mm and a height of 3 mm. To explore the effect of the scaffolding structure and MXene on the evaporation efficiency, three evaporators were prepared, namely, CPK (CW powder supported by hydrogel), CSK (CW with the scaffolding structure supported by hydrogel), and CMSK (CW with the scaffolding structure modified by MXene and supported by hydrogel).…”

Section: Materials M Leucadendron L Wood Was Provided By Lingfeimentioning

confidence: 99%

Highly Effective Multifunctional Solar Evaporator with Scaffolding Structured Carbonized Wood and Biohydrogel

Chen

Jian

Yang

et al. 2022

ACS Appl. Mater. Interfaces

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A solar evaporator that utilizes solar radiation energy can be a renewable approach to deal with energy crisis and fresh water shortage. In this study, a solar evaporator was prepared by assembling composite carbonized wood of Melaleuca Leucadendron L. and biobased hydrogel. The multilayer MXene (Ti 3 C 2 T x ) was embedded in the scaffolding structure of the wood to form composite carbonized wood, where the loose and ordered scaffolding structure of the carbonized wood significantly improves the efficiency of water transportation with increased capillary force. The MXene adsorbed in the carbonized wood has high binding energy with water molecules, leading to reduction of vaporization enthalpy and contact angle. Moreover, the addition of MXene can improve the light absorbance, especially for the infrared and ultraviolet light bands. The hydrogel was fabricated by crosslinking konjac glucomannan and sodium alginate polysaccharides with Ca 2+ , and it has a lower thermal conductivity than water and improves the evaporation efficiency by regulating the temperature distribution and concentrating the heat on the surface of the evaporator. This solar evaporator has an evaporation rate of 3.71 kg•m −2 •h −1 and an evaporation efficiency of 129.64% under 2 sun illumination and is available to generate an open-circuit voltage of 1.8 mV after a 20 min hydrovoltaic, demonstrating a high performance and versatility. Also, experiments and numerical simulation were carried out to understand the mechanism and design principles of this solar evaporators.

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“…The characteristic peaks at 1630 and 1413 cm −1 were ascribed to the asymmetric and symmetric stretching vibrations of the −COO − groups in PA-DI, respectively; 22 while the peaks appeared blue-shifted after soaking in a CaCl 2 aqueous solution and further blue-shifted to 1640 and 1419 cm −1 after soaking in a CaCl 2 binary (or polyol)/water solution (Figure 3a,b), indicating the formation of Alg-Ca ionic ions and hydrogen bonds in Alg chains. 22 Besides, the peak areas at 2946 and 1091 cm −1 for the typical vibrations of the C−H and O−H groups in PVA chains 23 increased after soaking treatment (Figure 3a), which indicated the formation of hydrogen bonds in the PVA chains. Accordingly, we deduced the formation of Alg-Ca ionic bonds and hydrogen bonds in CNOHs in the presence of Ca 2+ and the bridging molecules.…”

Section: Resultsmentioning

confidence: 97%

Tough and Antifreezing Organohydrogel Electrolyte for Flexible Supercapacitors with Wide Temperature Stability

Chen

Shi

et al. 2021

ACS Appl. Energy Mater.

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Hydrogels bridged by some alcohol compounds are reported to be useful for high tough and antifreezing properties of electronics and energy storage devices. However, the relationship between the structures of the alcohols on the mechanical and antifreezing properties is not clear yet. For a better understanding of the relationship and influence mechanism, conjoined-network organohydrogels connected with three typical alcohols (ethylene glycol, glycerol, and sorbitol) as bridging molecules were constructed by utilizing a poly(vinyl alcohol)/alginate-calcium (PVA/Alg-Ca) double-network hydrogel as a substrate. The results displayed that the organohydrogels exhibit high mechanical properties with a maximum at 2.4 MPa and good antifreezing performance with the lowest value at −61 °C. By further analyzing the mechanism by Fourier transform infrared spectroscopy (FTIR) and derivative thermogravimetry (DTG), it was observed that the hydrogen bonds among the bridging molecules, polymer chains, and water were considered to play a decisive role in the high performance of the organohydrogels. A high number of hydroxyl groups in the bridging molecules could be conducive to the better entanglement of polymer chains but less interaction with water. Nevertheless, under the synergistic effect of the hydrogen bonds and high-concentration free ions, the organohydrogels also delivered high ionic conductivity. Furthermore, an all-in-one flexible supercapacitor based on the organohydrogels was assembled. It delivered a superior areal specific capacitance of 140.75 mF cm–2 at 1.0 mA cm–2 and exhibited good flexibility and electrochemical stability under different bending conditions and a wide working temperature range (−20 to 60 °C). It could be promisingly applied in flexible energy storage devices working even in subzero environments.

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Fabrication of Konjac glucomannan-based composite hydrogel crosslinked by calcium hydroxide for promising lacrimal plugging purpose

Cited by 20 publications

References 43 publications

Efficacy, Drug Sensitivity, and Safety of a Chronic Ocular Hypertension Rat Model Established Using a Single Intracameral Injection of Hydrogel into the Anterior Chamber

Efficacy, Drug Sensitivity, and Safety of a Chronic Ocular Hypertension Rat Model Established Using a Single Intracameral Injection of Hydrogel into the Anterior Chamber

Highly Effective Multifunctional Solar Evaporator with Scaffolding Structured Carbonized Wood and Biohydrogel

Tough and Antifreezing Organohydrogel Electrolyte for Flexible Supercapacitors with Wide Temperature Stability

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