Fabrication of icariin-soymilk nanoparticles with ultrasound-assisted treatment

Wang, Jinping; Zhu, Hong; Jiang, Yueming; Xiao, Jianbo; Yang, Bao; Wen, Li

doi:10.1016/j.ultsonch.2022.106230

Cited by 6 publications

(2 citation statements)

References 47 publications

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“…In addition, polyphenols contained in PO may improve the strength and oxidation resistance of egg white gel under ultrasonic treatment. Recently, tea polyphenols-assisted ultrasound modification of egg white protein (TUEP) gel was studied, and the TUEP gel stability, hardness, and water-holding capacity were improved with combination treatment [32] , [33] . At present, artificial meat produced by plant-derived protein has received unprecedented attention, but improving the color of artificial meat is a challenge.…”

Section: Resultsmentioning

confidence: 99%

Ultrasound-assisted pH-shifting to construct a stable aqueous solution of paprika oleoresin using egg yolk low-density lipoprotein as a natural liposome-like nano-emulsifier

Ye,

Wang,

Xiao

et al. 2023

Ultrasonics Sonochemistry

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Section: Resultsmentioning

confidence: 99%

Ultrasound-assisted pH-shifting to construct a stable aqueous solution of paprika oleoresin using egg yolk low-density lipoprotein as a natural liposome-like nano-emulsifier

Ye,

Wang,

Xiao

et al. 2023

Ultrasonics Sonochemistry

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“…This method effectively incorporates the drug and greatly improves cell proliferation compared to using plain ICA. In another study, ICA-soymilk nanocomplexes were developed using an ultrasonic technique [ 125 ]. The results indicated a significant improvement in the solubility of ICA in water with the nanocomplexes (715–749 vs 39.03 µg/mL).…”

Section: Icariin-loaded Nanoplatformsmentioning

confidence: 99%

Promoting osteogenesis and bone regeneration employing icariin-loaded nanoplatforms

Mohammadzadeh,

Zarei,

Abbasi

et al. 2024

J Biol Eng

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There is an increasing demand for innovative strategies that effectively promote osteogenesis and enhance bone regeneration. The critical process of bone regeneration involves the transformation of mesenchymal stromal cells into osteoblasts and the subsequent mineralization of the extracellular matrix, making up the complex mechanism of osteogenesis. Icariin’s diverse pharmacological properties, such as anti-inflammatory, anti-oxidant, and osteogenic effects, have attracted considerable attention in biomedical research. Icariin, known for its ability to stimulate bone formation, has been found to encourage the transformation of mesenchymal stromal cells into osteoblasts and improve the subsequent process of mineralization. Several studies have demonstrated the osteogenic effects of icariin, which can be attributed to its hormone-like function. It has been found to induce the expression of BMP-2 and BMP-4 mRNAs in osteoblasts and significantly upregulate Osx at low doses. Additionally, icariin promotes bone formation by stimulating the expression of pre-osteoblastic genes like Osx, RUNX2, and collagen type I. However, icariin needs to be effectively delivered to bone to perform such promising functions.Encapsulating icariin within nanoplatforms holds significant promise for promoting osteogenesis and bone regeneration through a range of intricate biological effects. When encapsulated in nanofibers or nanoparticles, icariin exerts its effects directly at the cellular level. Recalling that inflammation is a critical factor influencing bone regeneration, icariin's anti-inflammatory effects can be harnessed and amplified when encapsulated in nanoplatforms. Also, while cell adhesion and cell migration are pivotal stages of tissue regeneration, icariin-loaded nanoplatforms contribute to these processes by providing a supportive matrix for cellular attachment and movement. This review comprehensively discusses icariin-loaded nanoplatforms used for bone regeneration and osteogenesis, further presenting where the field needs to go before icariin can be used clinically.

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Enhancing functionality and bioactivity of walnut protein through limited enzyme digestion

Wang,

Bi,

Zhou

et al. 2024

J Sci Food Agric

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BACKGROUNDWalnut protein (WP) is recognized as a valuable plant protein. However, the poor solubility and functional properties limit its application in the food industry. It is a great requirement to improve the physicochemical properties of WP.RESULTSFollowing a 90 min restricted enzymatic hydrolysis period, the solubility of WP significantly increased from 3.24% to 54.54%, with the majority of WP hydrolysates (WPHs) possessing a molecular weight exceeding 50 kDa. Circular dichroism spectra showed that post‐hydrolysis, the structure of the protein became more flexible, while the hydrolysis time did not significantly alter the protein's secondary structure. After hydrolysis, WP's surface hydrophobicity significantly increased from 2279 to 6100. Furthermore, WPHs exhibited a strong capacity for icariin loading and micelle formation with critical micelle concentration values of 0.71, 0.99 and 1.09 mg mL−1, respectively. Moreover, similar immuno‐enhancement activities were observed in WPHs. After exposure to WPHs, the pinocytosis of RAW264.7 macrophages was significantly improved. WPH treatment also increased the production of nitric oxide, interleukin‐6 (IL‐6) and tumor necrosis factor‐α (TNF‐α) in macrophages. Up‐regulation of mRNA expressions of IL‐6, inducible nitric oxide synthase (iNOS) and TNF‐α was observed in a dose‐dependent manner.CONCLUSIONThe enhancement of functionality and bioactivity in WP can be achieved through the application of limited enzyme digestion with trypsin. This process effectively augments the nutritional value and utility of the protein, making it a valuable component in various dietary applications. © 2024 Society of Chemical Industry.

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Fabrication of icariin-soymilk nanoparticles with ultrasound-assisted treatment

Cited by 6 publications

References 47 publications

Ultrasound-assisted pH-shifting to construct a stable aqueous solution of paprika oleoresin using egg yolk low-density lipoprotein as a natural liposome-like nano-emulsifier

Ultrasound-assisted pH-shifting to construct a stable aqueous solution of paprika oleoresin using egg yolk low-density lipoprotein as a natural liposome-like nano-emulsifier

Promoting osteogenesis and bone regeneration employing icariin-loaded nanoplatforms

Enhancing functionality and bioactivity of walnut protein through limited enzyme digestion

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