Fabrication of hybrid povidone-iodine impregnated collagen-hydroxypropyl methylcellulose composite scaffolds for wound-healing application

K, Sathesh Kumar; Deepa, S.; Sathiamurthi, P.; Arockiarajan, A.; Ganesan, Nalini; C, Senthil Kumar; Madhan, Balaraman

doi:10.1016/j.jddst.2022.103247

Cited by 8 publications

(2 citation statements)

References 63 publications

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“…These results are in line with previous reports indicating enhanced mechanical properties of biomaterials following inclusion of Gd and Iod reagents. [ 67‐70 ] Constructs fabricated with Au NP bioink showed significantly lower elastic modulus (23.9 ± 2.0 kPa) compared to the 20% GelMA control (142.2 ± 17.1 kPa). This may be due to disrupting effect of Au NPs on the GelMA hydrogel network by their physical size upon entrapment and/or their absorption/scattering of UV light during photocrosslinking.…”

Section: Resultsmentioning

confidence: 99%

Leveraging 3D Bioprinting and Photon‐Counting Computed Tomography to Enable Noninvasive Quantitative Tracking of Multifunctional Tissue Engineered Constructs

Gil,

Evans,

et al. 2023

Adv Healthcare Materials

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Abstract3D Bioprinting is revolutionizing the fields of personalized and precision medicine by enabling the manufacturing of bioartificial implants that recapitulate the structural and functional characteristics of native tissues. However, the lack of quantitative and noninvasive techniques to longitudinally track the function of implants has hampered clinical applications of bioprinted scaffolds. In this study, multimaterial 3D bioprinting, engineered nanoparticles (NPs), and spectral photon‐counting computed tomography (PCCT) technologies were integrated for the aim of developing a new precision medicine approach to custom‐engineer scaffolds with traceability. Multiple CT‐visible hydrogel‐based bioinks, containing distinct molecular (iodine and gadolinium) and NP (iodine‐loaded liposome, gold, methacrylated gold (AuMA), and Gd2O3) contrast agents, were used to bioprint scaffolds with varying geometries at adequate fidelity levels. In vitro release studies, together with printing fidelity, mechanical, and biocompatibility tests identified AuMA and Gd2O3 NPs as optimal reagents to track bioprinted constructs. Spectral PCCT imaging of scaffolds in vitro and subcutaneous implants in mice enabled noninvasive material discrimination and contrast agent quantification. Together, these results establish a novel theranostic platform with high precision, tunability, throughput, and reproducibility and open new prospects for a broad range of applications in the field of precision and personalized regenerative medicine.This article is protected by copyright. All rights reserved

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Section: Resultsmentioning

confidence: 99%

Leveraging 3D Bioprinting and Photon‐Counting Computed Tomography to Enable Noninvasive Quantitative Tracking of Multifunctional Tissue Engineered Constructs

Gil,

Evans,

et al. 2023

Adv Healthcare Materials

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“…Recent studies have taken a step further by exploring the combination of PVP-I with various biomaterials and antiseptics, aiming to potentially amplify its effectiveness as an antiseptic agent [35][36][37]. This evolving line of research holds promise in uncovering novel approaches to optimize the therapeutic potential of PVP-I, shedding light on its nuanced interactions with cells and tissues during the wound healing process.…”

Section: Introductionmentioning

confidence: 99%

Antiseptic, Hemostatic, and Wound Activity of Poly(vinylpyrrolidone)-Iodine Gel with Trimethyl Chitosan

Padalhin,

Ryu,

Yoo

et al. 2024

IJMS

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Wound management practices have made significant advancements, yet the search for improved antiseptics persists. In our pursuit of solutions that not only prevent infections but also address broader aspects of wound care, we investigated the impact of integrating trimethyl chitosan (TMC) into a widely used poly(vinylpyrrolidone)-iodine gel (PVP-I gel). Our study assessed the antimicrobial efficacy of the PVP gel with TMC against Escherichia coli, Staphylococcus aureus, multidrug-resistant S. aureus MRSA, and Candida albicans. Additionally, we compared hemostatic effects using a liver puncture bleeding model and evaluated wound healing through histological sections from full-thickness dermal wounds in rats. The results indicate that incorporating TMC into the commercially available PVP-I gel did not compromise its antimicrobial activity. The incorporation of TMC into the PVP-I gel markedly improves its hemostatic activity. The regular application of the PVP-I gel with TMC resulted in an increased blood vessel count in the wound bed and facilitated the development of thicker fibrous tissue with a regenerated epidermal layer. These findings suggest that TMC contributes not only to antimicrobial activity but also to the intricate processes of tissue regeneration. In conclusion, incorporating TMC proves beneficial, making it a valuable additive to commercially available antiseptic agents.

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Combination of polylactide with cellulose for biomedical applications: a recent overview

Kopańska,

Brzeziński,

Draczyński

2023

Cellulose

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This review summarizes the use of cellulose and polylactide for medical applications with particular emphasis on modern dressings. Although classic cotton and viscose dressings are still available and popular, the usefulness of new forms of cellulose (Cel) and its derivatives opens new wound treatment options. Therefore, trends in functionalizing traditional cellulose dressings, including products made of bacterial cellulose, and dressings from cellulose derivatives, are discussed. Polylactide (PLA), in turn, is a biodegradable and biocompatible polyester that fulfills plenty of tasks in many medical fields, from surgery to modern diagnostic methods. However, polylactide dressings can still be advantageous to the market. Thus, the next part of the article contains a recent update of available knowledge about PLA and its applications in regenerative medicine and drug-delivery systems. The last part is devoted to the possibilities of combining both materials in dressings and related problems and benefits. Methods for compatibilization with the surface of both polymers and new techniques for producing Cel/PLA composite materials are also described.

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Fabrication of hybrid povidone-iodine impregnated collagen-hydroxypropyl methylcellulose composite scaffolds for wound-healing application

Cited by 8 publications

References 63 publications

Leveraging 3D Bioprinting and Photon‐Counting Computed Tomography to Enable Noninvasive Quantitative Tracking of Multifunctional Tissue Engineered Constructs

Leveraging 3D Bioprinting and Photon‐Counting Computed Tomography to Enable Noninvasive Quantitative Tracking of Multifunctional Tissue Engineered Constructs

Antiseptic, Hemostatic, and Wound Activity of Poly(vinylpyrrolidone)-Iodine Gel with Trimethyl Chitosan

Combination of polylactide with cellulose for biomedical applications: a recent overview

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