Fabrication of hyaluronic acid-based micelles with glutathione-responsiveness for targeted anticancer drug delivery

Yan, Keding; Feng, Yecheng; Gao, Ke; Shi, Xiaojing; Zhao, Xubo

doi:10.1016/j.jcis.2021.08.129

Cited by 40 publications

(25 citation statements)

References 35 publications

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“…The assembly of these nanostructures is thermodynamically driven to minimize the free energy of the system. 127 Amphiphilic copolymers have two distinct parts in their structure: (i) a hydrophilic head and (ii) a hydrophobic tail. To minimize the free energy, the hydrophobic tails of the polymers assemble themselves to form a unique micellar structure where the hydrophilic part is "exposed" to the water molecules surrounding the micellar structures.…”

Section: Polymer-based Ndds In Cancer Therapymentioning

confidence: 99%

“…Micelles are three-dimensional nanosized aggregates of amphiphilic copolymers where the hydrodynamic diameter ranges from 10 to 100 nm. The assembly of these nanostructures is thermodynamically driven to minimize the free energy of the system . Amphiphilic copolymers have two distinct parts in their structure: (i) a hydrophilic head and (ii) a hydrophobic tail.…”

Section: Polymer-based Ndds In Cancer Therapymentioning

confidence: 99%

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Recent Progress in Nanostructured Smart Drug Delivery Systems for Cancer Therapy: A Review

Khan

Hossain

et al. 2022

ACS Appl. Bio Mater.

180

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Traditional treatment approaches for cancer involve intravenous chemotherapy or other forms of drug delivery. These therapeutic measures suffer from several limitations such as nonspecific targeting, poor biodistribution, and buildup of drug resistances. However, significant technological advancements have been made in terms of superior modes of drug delivery over the last few decades. Technical capability in analyzing the molecular mechanisms of tumor biology, nanotechnologyparticularly the development of biocompatible nanoparticles, surface modification techniques, microelectronics, and material scienceshas increased. As a result, a significant number of nanostructured carriers that can deliver drugs to specific cancerous sites with high efficiency have been developed. This particular maneuver that enables the introduction of a therapeutic nanostructured substance in the body by controlling the rate, time, and place is defined as the nanostructured drug delivery system (NDDS). Because of their versatility and ability to incorporate features such as specific targeting, water solubility, stability, biocompatibility, degradability, and ability to reverse drug resistance, they have attracted the interest of the scientific community, in general, and nanotechnologists as well as biomedical scientists. To keep pace with the rapid advancement of nanotechnology, specific technical aspects of the recent NDDSs and their prospects need to be reported coherently. To address these ongoing issues, this review article provides an overview of different NDDSs such as lipids, polymers, and inorganic nanoparticles. In addition, this review also reports the challenges of current NDDSs and points out the prospective research directions of these nanocarriers. From our focused review, we conclude that still now the most advanced and potent field of application for NDDSs is lipid-based, while other significantly potential fields include polymer-based and inorganic NDDSs. However, despite the promises, challenges remain in practical implementations of such NDDSs in terms of dosage and stability, and caution should be exercised regarding biocompatibility of materials. Considering these aspects objectively, this review on NDDSs will be particularly of interest for small-to-large scale industrial researchers and academicians with expertise in drug delivery, cancer research, and nanotechnology.

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Section: Polymer-based Ndds In Cancer Therapymentioning

confidence: 99%

Section: Polymer-based Ndds In Cancer Therapymentioning

confidence: 99%

Recent Progress in Nanostructured Smart Drug Delivery Systems for Cancer Therapy: A Review

Khan

Hossain

et al. 2022

ACS Appl. Bio Mater.

180

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“…Therefore, a large number of smart DDSs including polymeric NPs [ 178 ], SiO 2 NPs [ 179 ] and metal-based NPs [ 5 , 180 ], etc. are developed, which can response to the unique TME such as low pH [ 181 ], high glutathione (GSH) [ 182 ] and enzyme [ 183 ], etc., as well external triggers like photo [ 184 ] and ultrasound [ 185 ], etc. for site-specific drug release with higher tumor accumulation and reduced systemic toxicities.…”

Section: Hollow Nanoplatforms For Nir-ii Ptt-based Dual-modal Therapiesmentioning

confidence: 99%

Recent advances in near-infrared-II hollow nanoplatforms for photothermal-based cancer treatment

et al. 2022

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Near-infrared-II (NIR-II, 1000–1700 nm) light-triggered photothermal therapy (PTT) has been regarded as a promising candidate for cancer treatment, but PTT alone often fails to achieve satisfactory curative outcomes. Hollow nanoplatforms prove to be attractive in the biomedical field owing to the merits including good biocompatibility, intrinsic physical-chemical nature and unique hollow structures, etc. On one hand, hollow nanoplatforms themselves can be NIR-II photothermal agents (PTAs), the cavities of which are able to carry diverse therapeutic units to realize multi-modal therapies. On the other hand, NIR-II PTAs are capable of decorating on the surface to combine with the functions of components encapsulated inside the hollow nanoplatforms for synergistic cancer treatment. Notably, PTAs generally can serve as good photoacoustic imaging (PAI) contrast agents (CAs), which means such kind of hollow nanoplatforms are also expected to be multifunctional all-in-one nanotheranostics. In this review, the recent advances of NIR-II hollow nanoplatforms for single-modal PTT, dual-modal PTT/photodynamic therapy (PDT), PTT/chemotherapy, PTT/catalytic therapy and PTT/gas therapy as well as multi-modal PTT/chemodynamic therapy (CDT)/chemotherapy, PTT/chemo/gene therapy and PTT/PDT/CDT/starvation therapy (ST)/immunotherapy are summarized for the first time. Before these, the typical synthetic strategies for hollow structures are presented, and lastly, potential challenges and perspectives related to these novel paradigms for future research and clinical translation are discussed. Graphical Abstract

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“…Red fluorescence was observed as the DOX is released at the nucleus. Hence the results demonstrate that the polymeric micelle is highly effective and helps in the drug release mechanism [ 157 ]. Sun and group designed polymeric multifunctional AIE active redox-sensitive nanocarrier for bioimaging which can be used for a drug delivery system.…”

Section: Aie Molecules For Drug Delivery Systemsmentioning

confidence: 99%

Recent Advances in Aggregation-Induced Emission Active Materials for Sensing of Biologically Important Molecules and Drug Delivery System

et al. 2021

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The emergence and development of aggregation induced emission (AIE) have attracted worldwide attention due to its unique photophysical phenomenon and for removing the obstacle of aggregation-caused quenching (ACQ) which is the most detrimental process thereby making AIE an important and promising aspect in various fields of fluorescent material, sensing, bioimaging, optoelectronics, drug delivery system, and theranostics. In this review, we have discussed insights and explored recent advances that are being made in AIE active materials and their application in sensing, biological cell imaging, and drug delivery systems, and, furthermore, we explored AIE active fluorescent material as a building block in supramolecular chemistry. Herein, we focus on various AIE active molecules such as tetraphenylethylene, AIE-active polymer, quantum dots, AIE active metal-organic framework and triphenylamine, not only in terms of their synthetic routes but also we outline their applications. Finally, we summarize our view of the construction and application of AIE-active molecules, which thus inspiring young researchers to explore new ideas, innovations, and develop the field of supramolecular chemistry in years to come.

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Fabrication of hyaluronic acid-based micelles with glutathione-responsiveness for targeted anticancer drug delivery

Cited by 40 publications

References 35 publications

Recent Progress in Nanostructured Smart Drug Delivery Systems for Cancer Therapy: A Review

Recent Progress in Nanostructured Smart Drug Delivery Systems for Cancer Therapy: A Review

Recent advances in near-infrared-II hollow nanoplatforms for photothermal-based cancer treatment

Recent Advances in Aggregation-Induced Emission Active Materials for Sensing of Biologically Important Molecules and Drug Delivery System

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