Fabrication of high strength, antibacterial and biocompatible Ti-5Mo-5Ag alloy for medical and surgical implant applications

Zhang, Yiwen; Chu, Kangjie; He, Shan; Bi, Wang; Zhu, Weiwei; Ren, Fuzeng

doi:10.1016/j.msec.2019.110165

Cited by 37 publications

(21 citation statements)

References 59 publications

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“…Modern beta type alloys contain nontoxic elements and are characterized by high strength, very low elastic modulus, good corrosion resistance, and excellent biocompatibility in comparison to other biometals [4,5]. An examples of modern beta titanium alloys are Ti-5Mo-5Ag [6], Ti-xMo (x-23%-35wt.%) [5,7], Ti14Zr16Nb [4], Ti23Zr25Nb [4], Ti-6Al-2Nb-2Ta-1Mo [8], Ti-15Mo-Zr [9]. It is worth mentioning that a great effort was put into the research and development of Ti-Mo alloys because of their surgical application [10,11].…”

Section: Introductionmentioning

confidence: 99%

Low-Temperature Hydrothermal Treatment Surface Functionalization of the Ultrafine-Grained TiMo Alloys for Medical Applications

2020

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Hydroxyapatite (HAp) is the most widely used material for bio coating. The functional layer can be produced by many methods, however, the most perspective by its utility, easy to scale up, and simplicity aspects remains a hydrothermal treatment approach. In this work, an HAp coating was produced by low-temperature hydrothermal treatment on the ultrafine-grain beta Ti-xMo (x = 23, 27, 35 wt.%) alloys. The proposed surface treatment procedure combines acid etching, alkaline treatment (AT), and finally hydrothermal treatment (HT). The uniqueness of the approach relies on the recognition of the influence of the molar concentration of NaOH (5 M, 7 M, 10 M, 12 M) during the alkaline treatment on the growth of hydroxyapatite crystals. Obtained and modified specimens were examined structurally and microstructurally at every stage of the process. The results show that the layer after AT consist of titanium oxide and phases based on sodium with various phase relations dependent on NaOH concentration and base composition. The AT in 7 M and 10 M enables to obtain the HAp layer, which can be characterized as the most developed in terms of thickness and porosity. Finally, selected coated samples were investigated in terms of surface wettability test managed in time relation, which for the results confirm high hydrophilicity of the surfaces. Conducted research shows that the low-temperature hydrothermal processing could be considered for a possible adaptation in the drug encapsulation and delivery systems.

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Section: Introductionmentioning

confidence: 99%

Low-Temperature Hydrothermal Treatment Surface Functionalization of the Ultrafine-Grained TiMo Alloys for Medical Applications

2020

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“…For the viability experiment, a common step is to rinse the substrates to remove non-adhered or weakly-adhered bacteria from the surface before conducting quantication test such as live dead analysis or colony counting. 31,33,37,38,40,45,47,51,53,55,56,59,63,[66][67][68][69][70][71][72][73][74][75][76][77][78][79][80][81][82][83][84][85] Commonly used rinsing methods are summarised in Table 1. Strikingly, the volumes or owrates used in the rinsing step of these studies are unspeci-ed, and the effect of stresses exerted on the loosely attached bacterial cells have not been accounted for.…”

Section: Rinsing Substrate For Removing Non-adhered Bacteriamentioning

confidence: 99%

Bactericidal efficiency of micro- and nanostructured surfaces: a critical perspective

et al. 2021

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“…Bacterial infection has been indicated as one of the main factors in the failure of metallic implants [102]. β-Ti alloys have been widely used in medical and surgical implants, but they are currently facing the challenge of implant-related infections [83]. Hence, it is crucial to improve the antibacterial property of the β-Ti alloys.…”

Section: Biological Response 61 Antibacterial Propertymentioning

confidence: 99%

β-Ti Alloys for Orthopedic and Dental Applications: A Review of Progress on Improvement of Properties through Surface Modification

Shao

Dai

et al. 2021

Coatings

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Ti and Ti alloys have charming comprehensive properties (high specific strength, strong corrosion resistance, and excellent biocompatibility) that make them the ideal choice in orthopedic and dental applications, especially in the particular fabrication of orthopedic and dental implants. However, these alloys present some shortcomings, specifically elastic modulus, wear, corrosion, and biological performance. Beta-titanium (β-Ti) alloys have been studied as low elastic modulus and low toxic or non-toxic elements. The present work summarizes the improvements of the properties systematically (elastic modulus, hardness, wear resistance, corrosion resistance, antibacterial property, and bone regeneration) for β-Ti alloys via surface modification to address these shortcomings. Additionally, the shortcomings and prospects of the present research are put forward. β-Ti alloys have potential regarding implants in biomedical fields.

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Fabrication of high strength, antibacterial and biocompatible Ti-5Mo-5Ag alloy for medical and surgical implant applications

Cited by 37 publications

References 59 publications

Low-Temperature Hydrothermal Treatment Surface Functionalization of the Ultrafine-Grained TiMo Alloys for Medical Applications

Low-Temperature Hydrothermal Treatment Surface Functionalization of the Ultrafine-Grained TiMo Alloys for Medical Applications

Bactericidal efficiency of micro- and nanostructured surfaces: a critical perspective

β-Ti Alloys for Orthopedic and Dental Applications: A Review of Progress on Improvement of Properties through Surface Modification

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