Fabrication of heterogeneous chemical patterns on stretchable hydrogels using single-photon lithography

Im, Haeseong; Heo, Eunseok; Song, Dae-Hyeon; Park, Jeongwon; Park, Hyeonbin; Kang, Kibum; Chang, Jae-Byum

doi:10.1039/d2sm00253a

Soft Matter

2022

DOI: 10.1039/d2sm00253a

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Fabrication of heterogeneous chemical patterns on stretchable hydrogels using single-photon lithography

Haeseong Im

Eunseok Heo

Dae-Hyeon Song

et al.

Abstract: Curved hydrogel surfaces bearing chemical patterns are highly desirable in various applications, including artificial blood vessels, wearable electronics, and soft robotics. However, previous studies on the fabrication of chemical patterns...

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Cited by 2 publications

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Facile Photopatterning of Perfusable Microchannels in Synthetic Hydrogels to Recreate Microphysiological Environments

Mora‐Boza,

Mulero‐Russe,

Caprio

et al. 2023

Advanced Materials

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The fabrication of perfusable hydrogels is crucial for recreating in vitro microphysiological environments. Existing strategies to fabricate complex microchannels in hydrogels involve sophisticated equipment/techniques. We report a cost‐effective, facile, versatile, and ultra‐fast methodology to fabricate perfusable microchannels of complex shapes in photopolymerizable hydrogels without the need of specialized equipment or sophisticated protocols. Our methodology utilizes one‐step UV light‐triggered crosslinking and a photomask printed on inexpensive transparent films to photopattern PEG‐norbornene hydrogels. Complex and intricate patterns with high resolution, including perfusable microchannels, can be fabricated in <1 second. We integrate the perfusable hydrogel into a custom‐made microfluidic device that permits connection to external pump systems, allowing continuous fluid perfusion into the microchannels. Under dynamic culture, human endothelial cells form a functional and confluent endothelial monolayer that remains viable for at least 7 days and respond to inflammatory stimuli. Finally, we adapt our approach to photopattern norbornene hyaluronic acid hydrogels, highlighting the versatility of the technique. This study presents an innovative strategy to simplify and reduce the cost of biofabrication techniques for developing functional in vitro models using perfusable 3D hydrogels. Our approach offers a novel solution to overcome the complexities associated with existing methods, allowing engineering advanced in vitro microphysiological environments.This article is protected by copyright. All rights reserved

show abstract

Facile Photopatterning of Perfusable Microchannels in Synthetic Hydrogels to Recreate Microphysiological Environments

Mora‐Boza,

Mulero‐Russe,

Caprio

et al. 2023

Advanced Materials

View full text Add to dashboard Cite

show abstract

Facile photopatterning of perfusable microchannels in hydrogels for microphysiological systems

Mora-Boza,

Mulero-Russe,

Di Caprio

et al. 2024

Nat Protoc

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Fabrication of heterogeneous chemical patterns on stretchable hydrogels using single-photon lithography

Abstract: Curved hydrogel surfaces bearing chemical patterns are highly desirable in various applications, including artificial blood vessels, wearable electronics, and soft robotics. However, previous studies on the fabrication of chemical patterns...

Cited by 2 publications

References 77 publications

Facile Photopatterning of Perfusable Microchannels in Synthetic Hydrogels to Recreate Microphysiological Environments

Facile Photopatterning of Perfusable Microchannels in Synthetic Hydrogels to Recreate Microphysiological Environments

Facile photopatterning of perfusable microchannels in hydrogels for microphysiological systems

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