Fabrication of HA/PLLA Composite Scaffolds for Bone Tissue Engineering Using Additive Manufacturing Technologies

Cruz, Fernando Luiz Goulart

doi:10.5772/10264

Cited by 16 publications

(17 citation statements)

References 7 publications

(6 reference statements)

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“…However, a higher HA content is usually difficult to achieve in such a composite while maintaining its mechanical strength; as noted, regular HA‐polymer composites described in the literature possess typically only 50 vol% of HA . In this regard, the present nacre‐mimetic HA/PMMA composite appears to be distinctly superior to previous HA/polymer composites that have been developed, in terms of ceramic content and the critical structural properties of stiffness, strength, and work of fracture (Figure b,c) . Akin to nacre, the subtle organization of multiple‐scale architectures induces the improved mechanical properties of these composites.…”

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confidence: 74%

Bioinspired Hydroxyapatite/Poly(methyl methacrylate) Composite with a Nacre‐Mimetic Architecture by a Bidirectional Freezing Method

et al. 2015

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Using a bidirectional freezing technique, combined with uniaxial pressing and in situ polymerization, "nacre-mimetic" hydroxyapatite/poly(methyl methacrylate) (PMMA) composites are developed by processing large-scale aligned lamellar ceramic scaffolds. Structural and mechanical characterization shows "brick-and-mortar" structures, akin to nacre, with interesting combinations of strength, stiffness, and work of fracture, which provide a pathway to making strong and tough lightweight materials.

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confidence: 74%

Bioinspired Hydroxyapatite/Poly(methyl methacrylate) Composite with a Nacre‐Mimetic Architecture by a Bidirectional Freezing Method

et al. 2015

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“…The main advantages of these polymers are their mechanical strength, combined with biodegradability and biocompatibility 57 . In a similar study, PLLA nanofibers scaffolds with growth factors were examined in the calvariom bone defect and results showed that scaffold had bone…”

Section: Discussionmentioning

confidence: 99%

Combination of poly L-lactic acid nanofiber scaffold with omentum graft for bone healing in experimental defect in tibia of rabbits

Sotoudeh

Jahanshahi²,

Jahanshahi³

et al. 2012

Acta Cir. Bras.

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PURPOSE: To investigate the osteoconductive properties and biological performance of Poly L-lactic acid (PLLA) with omentum in bone defects. METHODS: PLLA nanofiber scaffolds were prepared via electrospinning technique. Forty four New Zealand white female rabbits randomly divided into three groups of 18 rabbits each. Created defects in right tibias were filled in group I with omentum, in group II with PLLA nanofiber scaffold and in group III with combination of the omentum and PLLA. The same defects were created in left tibia of all groups but did not receive any treatment (control group). Histological and histomorphometric evaluations were performed at two, four and six weeks after the implantation. RESULTS: Histological changes on all groups along with the time course were scored and statistical analysis showed that the average scores in group III were significantly higher than the other groups. CONCLUSION: Histomorphometric analysis of bone healing was shown to be significantly improved by the combined PLLA with omentum compared with the other groups, suggesting this biomaterial promote the healing of cortical bone, presumably by acting as an osteoconductive scaffold.

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“…Many concerns need to be considered before broad usage of biosustainable polymer are achievable, such as technical and production problems. Their functional features appear negative compared to established petroleum-based polymers and a fundamental hurdle to the wider application of biopolymer in numerous areas [32,33]. For example, the performance of a component of biopolymers with single bonds is less than that of plastic materials as it results in a poorer mechanical characteristic.…”

Section: Biopolymers and Typesmentioning

confidence: 99%

Additive Manufacturing of Biopolymers for Tissue Engineering and Regenerative Medicine: An Overview, Potential Applications, Advancements, and Trends

Veeman

Sai

Sureshkumar³

et al. 2021

International Journal of Polymer Science

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As a technique of producing fabric engineering scaffolds, three-dimensional (3D) printing has tremendous possibilities. 3D printing applications are restricted to a wide range of biomaterials in the field of regenerative medicine and tissue engineering. Due to their biocompatibility, bioactiveness, and biodegradability, biopolymers such as collagen, alginate, silk fibroin, chitosan, alginate, cellulose, and starch are used in a variety of fields, including the food, biomedical, regeneration, agriculture, packaging, and pharmaceutical industries. The benefits of producing 3D-printed scaffolds are many, including the capacity to produce complicated geometries, porosity, and multicell coculture and to take growth factors into account. In particular, the additional production of biopolymers offers new options to produce 3D structures and materials with specialised patterns and properties. In the realm of tissue engineering and regenerative medicine (TERM), important progress has been accomplished; now, several state-of-the-art techniques are used to produce porous scaffolds for organ or tissue regeneration to be suited for tissue technology. Natural biopolymeric materials are often better suited for designing and manufacturing healing equipment than temporary implants and tissue regeneration materials owing to its appropriate properties and biocompatibility. The review focuses on the additive manufacturing of biopolymers with significant changes, advancements, trends, and developments in regenerative medicine and tissue engineering with potential applications.

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Fabrication of HA/PLLA Composite Scaffolds for Bone Tissue Engineering Using Additive Manufacturing Technologies

Cited by 16 publications

References 7 publications

Bioinspired Hydroxyapatite/Poly(methyl methacrylate) Composite with a Nacre‐Mimetic Architecture by a Bidirectional Freezing Method

Bioinspired Hydroxyapatite/Poly(methyl methacrylate) Composite with a Nacre‐Mimetic Architecture by a Bidirectional Freezing Method

Combination of poly L-lactic acid nanofiber scaffold with omentum graft for bone healing in experimental defect in tibia of rabbits

Additive Manufacturing of Biopolymers for Tissue Engineering and Regenerative Medicine: An Overview, Potential Applications, Advancements, and Trends

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