Fabrication of gradient porous microneedle array by modified hot embossing for transdermal drug delivery

Li, Jiyu; Zhou, Yingying; Yang, Jingbo; Rui, Yong; Gao, Jie; Ren, Lei; Liu, Bin; Liang, Liang; Jiang, Lelun

doi:10.1016/j.msec.2018.11.074

Cited by 82 publications

(65 citation statements)

References 47 publications

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“…This is because certain medications and vaccinations are thermolabile, and micro forming allows for the preparation of needles in mild conditions [ 51 ]. Usually, hot embossing methods, investment molding, and injection molding are used to fabricate degradable and insoluble MNs, but due to relatively high processing temperatures, the drug activity may be easily affected [ 140 , 141 , 142 , 143 , 144 , 145 ]. The casting method is currently the most used method to prepare dissolvable polymer MNs due to the advantages of low processing temperature, convenient fabrication process, and insignificant impact on drug activity [ 145 , 146 ].…”

Section: Polymeric Microneedle Manufacturing Techniquesmentioning

confidence: 99%

Translation of Polymeric Microneedles for Treatment of Human Diseases: Recent Trends, Progress, and Challenges

Yadav

Munni²,

Campbell

et al. 2021

Pharmaceutics

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The ongoing search for biodegradable and biocompatible microneedles (MNs) that are strong enough to penetrate skin barriers, easy to prepare, and can be translated for clinical use continues. As such, this review paper is focused upon discussing the key points (e.g., choice polymeric MNs) for the translation of MNs from laboratory to clinical practice. The review reveals that polymers are most appropriately used for dissolvable and swellable MNs due to their wide range of tunable properties and that natural polymers are an ideal material choice as they structurally mimic native cellular environments. It has also been concluded that natural and synthetic polymer combinations are useful as polymers usually lack mechanical strength, stability, or other desired properties for the fabrication and insertion of MNs. This review evaluates fabrication methods and materials choice, disease and health conditions, clinical challenges, and the future of MNs in public healthcare services, focusing on literature from the last decade.

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Section: Polymeric Microneedle Manufacturing Techniquesmentioning

confidence: 99%

Translation of Polymeric Microneedles for Treatment of Human Diseases: Recent Trends, Progress, and Challenges

Yadav

Munni²,

Campbell

et al. 2021

Pharmaceutics

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show abstract

“…Ceramics, especially bio-ceramics, have been used in drug delivery for a long time. Porous ceramic-based MNs allow the drug to be incorporated in the interconnected pores and to diffuse directly after interposition [39,58,59]. Its inherent porosity endows the MNs with the ability to load drugs without extra fabrication process [60].…”

Section: Ceramicsmentioning

confidence: 99%

Engineering Microneedles for Therapy and Diagnosis: A Survey

et al. 2020

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Microneedle (MN) technology is a rising star in the point-of-care (POC) field, which has gained increasing attention from scientists and clinics. MN-based POC devices show great potential for detecting various analytes of clinical interests and transdermal drug delivery in a minimally invasive manner owing to MNs’ micro-size sharp tips and ease of use. This review aims to go through the recent achievements in MN-based devices by investigating the selection of materials, fabrication techniques, classification, and application, respectively. We further highlight critical aspects of MN platforms for transdermal biofluids extraction, diagnosis, and drug delivery assisted disease therapy. Moreover, multifunctional MNs for stimulus-responsive drug delivery systems were discussed, which show incredible potential for accurate and efficient disease treatment in dynamic environments for a long period of time. In addition, we also discuss the remaining challenges and emerging trend of MN-based POC devices from the bench to the bedside.

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“…Nowadays, polymeric MNs have attracted great attention of researchers because most polymeric MNs are biocompatible and biodegradable to avoid harsh side effects in the skin, providing a safe device for the delivery of drugs. 30,104,112,123 Polymeric materials have been efficiently fabricated into solid MNs, coated MNs, dissolving MNs, and hollow MNs, including polymethyl methacrylate, 21,97,124 PLA, 55,94,112 polyglycolic acid, 101,98 polylactic-co-glycolic acid), 95,125 PVP, 22,54,104,126 polycaprolactone (PCL), 102,127 PVA, 103,105 and carboxymethyl cellulose (CMC). 106,128,129 However, most polymers are too soft to induce the buckling failure during the insertion process.…”

Section: Classified By Materials Of Mnsmentioning

confidence: 99%

Microneedle System for Transdermal Drug and Vaccine Delivery: Devices, Safety, and Prospects

Sun

Zhuang

et al. 2019

Dose-Response

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Microneedle (MN) delivery system has been greatly developed to deliver drugs into the skin painlessly, noninvasively, and safety. In the past several decades, various types of MNs have been developed by the newer producing techniques. Briefly, as for the morphologically, MNs can be classified into solid, coated, dissolved, and hollow MN, based on the transdermal drug delivery methods of “poke and patch,” “coat and poke,” “poke and release,” and “poke and flow,” respectively. Microneedles also have other characteristics based on the materials and structures. In addition, various manufacturing techniques have been well-developed based on the materials. In this review, the materials, structures, morphologies, and fabricating methods of MNs are summarized. A separate part of the review is used to illustrate the application of MNs to deliver vaccine, insulin, lidocaine, aspirin, and other drugs. Finally, the review ends up with a perspective on the challenges in research and development of MNs, envisioning the future development of MNs as the next generation of drug delivery system.

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Fabrication of gradient porous microneedle array by modified hot embossing for transdermal drug delivery

Cited by 82 publications

References 47 publications

Translation of Polymeric Microneedles for Treatment of Human Diseases: Recent Trends, Progress, and Challenges

Translation of Polymeric Microneedles for Treatment of Human Diseases: Recent Trends, Progress, and Challenges

Engineering Microneedles for Therapy and Diagnosis: A Survey

Microneedle System for Transdermal Drug and Vaccine Delivery: Devices, Safety, and Prospects

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