Fabrication of flexible microelectrode arrays integrated with microfluidic channels for stable neural interfaces

Gao, Kunpeng; Li, Gang; Liao, Lingying; Ji, Cheng; Zhao, Jianlong; Xu, Yuanfan

doi:10.1016/j.sna.2013.04.005

Cited by 35 publications

(32 citation statements)

References 18 publications

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“…In terms of Fick′s second law, we have

true \frac{\partial Δ C_{A}}{\partial t} = D_{A} ((), \frac{\partial^{2} Δ C_{normalA}}{\partial x^{2}})

true \frac{\partial Δ C_{B}}{\partial t} = D_{B} ((), \frac{\partial^{2} Δ C_{normalB}}{\partial {(d - x)}^{2}}) = D_{B} ((), \frac{\partial^{2} Δ C_{normalB}}{\partial x^{2}})

…”

Section: Theoretical Methodssupporting

confidence: 58%

EIS Theory of Relative Diffusion of Two Ions in Finite Diffusion Layer

2017

ChemistrySelect

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A oversimplified physical model has been constructed and then the mathematical model of electrochemical impedance of relative diffusion of two ions has been obtained. And the corresponding spectrum has been drawn from the model, which fills up the blank of the electrochemical impedance (EIS) theory in the field of multi-ion diffusion impedance. It is shown that the reaction order, surface concentration and diffusion coefficient are the three principle factors influencing the diffusion impedance, among which, the diffusion coefficient has the greatest influence. By controlling the relative value of the diffusion coefficient of the two ions, finally a series of regular EIS spectra has been got.

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“…In terms of Fick′s second law, we have

true \frac{\partial Δ C_{A}}{\partial t} = D_{A} ((), \frac{\partial^{2} Δ C_{normalA}}{\partial x^{2}})

true \frac{\partial Δ C_{B}}{\partial t} = D_{B} ((), \frac{\partial^{2} Δ C_{normalB}}{\partial {(d - x)}^{2}}) = D_{B} ((), \frac{\partial^{2} Δ C_{normalB}}{\partial x^{2}})

…”

Section: Theoretical Methodssupporting

confidence: 58%

EIS Theory of Relative Diffusion of Two Ions in Finite Diffusion Layer

2017

ChemistrySelect

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show abstract

“…[258][259][260][261][262][263] Microfluidic channels are fabricated within these probes, which can serve as drug depots and pathways for drug discharge ( Figure 10B). Some microprobes mostly combined with microelectrodes have been created to deliver bioactive compounds directly into the brain or central nervous system and simultaneously record and manipulate neuronal activity.…”

Section: Devices Applied To Specific Sitesmentioning

confidence: 99%

Microfabricated Drug Delivery Devices: Design, Fabrication, and Applications

Zhang

Jackson

Chiao

2017

Adv Funct Materials

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Microfabrication technology has enabled the development of novel controlled-release devices that possess an integration of structural, mechanical, and perhaps electronic features, which may address challenges associated with conventional delivery systems. In this feature article, microfabricated devices are described in terms of materials, mechanical design, working principles, and fabrication methods, all of which are key features for production of multifunctional, highly effective drug delivery systems. In addition, the current status and future prospects of different types of microfabricated devices for controlled drug delivery are summarized and analyzed with an emphasis on various routes of administration including ocular, oral, transdermal, and implantable systems. It is likely that microfabrication technology will continue to offer new, alternative solutions to design advanced and sophisticated drug delivery devices that promise to significantly improve medical care.

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“…Considering these facts, the microelectrodes integrated with micro channels for fluidic drug delivery were developed in recent year [15][16][17]. As majority of these studies focused on stiff electrodes which made of silicon or SU-8 for applications on central nerve system, only a few concentrated on flexible electrodes which made of parylene, polyimide (PI) and polydimethylsiloxane (PDMS) [18][19][20]. The problem that limits the precise stimulation by the polymer based flexible electrodes described above is that the electrode sites distributed on one side of the electrode.…”

Section: Flexible Mems Microelectrodes For Neural Interfacementioning

confidence: 99%

“…Kunpeng Gao and Gang Li et al of Shanghai Institute of Micro-System and Information Technology (Chinese Academy of Sciences) developed flexible MEMS microelectrodes with fluidic channels based on poly-dimethylsiloxane (PDMS) in 2013 [20]. As shown in Figure 6c, the thickness of the microelectrode array was 125 μm.…”

Section: Flexible Mems Microelectrodes With Fluidic Channels For Neurmentioning

confidence: 99%

Progress in Research of Flexible MEMS Microelectrodes for Neural Interface

Tang¹,

Tian²,

Kang³

et al. 2017

Preprint

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Abstract:With the rapid development of MEMS (Micro-electro-mechanical Systems) fabrication technologies, manifolds microelectrodes with various structures and functions have been designed and fabricated for applications in biomedical research, diagnosis and treatment through electrical stimulation and electrophysiological signal recording. The flexible MEMS microelectrodes exhibit multi-aspect excellent characteristics beyond stiff microelectrodes based on silicon or SU-8, which comprising: lighter weight, smaller volume, better conforming to neural tissue and lower fabrication cost. In this paper, we mainly reviewed key technologies on flexible MEMS microelectrodes for neural interface in recent years, including: design and fabrication technology, flexible MEMS microelectrodes with fluidic channels and electrode-tissue interface modification technology for performance improvement. Furthermore, the future directions of flexible MEMS microelectrodes for neural interface were described including transparent and stretchable microelectrodes integrated with multi-aspect functions and next-generation electrode-tissue interface modifications facilitated electrode efficacy and safety during implantation. Finally, the combinations among micro fabrication techniques with biomedical engineering and nanotechnology represented by flexible MEMS microelectrodes for neural interface will open a new gate to human lives and understanding of the world.

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Fabrication of flexible microelectrode arrays integrated with microfluidic channels for stable neural interfaces

Cited by 35 publications

References 18 publications

EIS Theory of Relative Diffusion of Two Ions in Finite Diffusion Layer

EIS Theory of Relative Diffusion of Two Ions in Finite Diffusion Layer

Microfabricated Drug Delivery Devices: Design, Fabrication, and Applications

Progress in Research of Flexible MEMS Microelectrodes for Neural Interface

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