Fabrication of fibrillated and interconnected porous poly(ε-caprolactone) vascular tissue engineering scaffolds by microcellular foaming and polymer leaching

Hou, Jianhua; Jiang, Jing; Guo, Huijun; Guo, Xin; Wang, Xiaofeng; Shen, Yaqiang; Li, Qian

doi:10.1039/d0ra00956c

Cited by 29 publications

(26 citation statements)

References 48 publications

(45 reference statements)

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“…Pore size in an engineered porous scaffold refers to pore geometry achieved by implementing various techniques to incorporate mesoscopic (>50 μm) and microscopic (1–50 μm) pores within the scaffold for facilitating tissue invasion ( 10 ). Achieving a hierarchical distribution of pores throughout a scaffold is crucial as pore size influences tissue shape, cell function and the rate and depth of tissue invasion.…”

Section: Porous Scaffolds and Vascularizationmentioning

confidence: 99%

Applications of Engineering Techniques in Microvasculature Design

Halawani

Wang

Liu

et al. 2021

Front. Cardiovasc. Med.

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Achieving successful microcirculation in tissue engineered constructs in vitro and in vivo remains a challenge. Engineered tissue must be vascularized in vitro for successful inosculation post-implantation to allow instantaneous perfusion. To achieve this, most engineering techniques rely on engineering channels or pores for guiding angiogenesis and capillary tube formation. However, the chosen materials should also exhibit properties resembling the native extracellular matrix (ECM) in providing mechanical and molecular cues for endothelial cells. This review addresses techniques that can be used in conjunction with matrix-mimicking materials to further advance microvasculature design. These include electrospinning, micropatterning and bioprinting. Other techniques implemented for vascularizing organoids are also considered for their potential to expand on these approaches.

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Section: Porous Scaffolds and Vascularizationmentioning

confidence: 99%

Applications of Engineering Techniques in Microvasculature Design

Halawani

Wang

Liu

et al. 2021

Front. Cardiovasc. Med.

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“…This phenomenon can be attributed to the fact that the network space filled with LDC, and the interaction between LDC and COP-THB lead the hydrogels space to be compressed. The surface morphology of spherical COP-THB and COP-THB/LDC hydrogel when analyzed at higher resolution exhibited a highly interconnected porous structure with an average pore size of 395 and 182 lm (Figure 7(c,d)) (Hou et al, 2020). Many studies have found that porous structures with a diameter of 150-300 mm are useful for tissue regeneration (Loh & Choong, 2013;Bru zauskait _ e et al, 2016).…”

Section: Microscopy Analysis Of Cop-thb/ldc Hydrogelsmentioning

confidence: 93%

Facile design of lidocaine-loaded polymeric hydrogel to persuade effects of local anesthesia drug delivery system: complete in vitro and in vivo toxicity analyses

Zhao

et al. 2021

Drug Delivery

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The principal goal of the present investigation was to enterprise new and effective drug delivery vesicle for the sustained delivery of local anesthetic lidocaine hydrochloride (LDC), using a novel combination of copolymeric hydrogel with tetrahydroxyborate (COP-THB) to improve bioactivity and therapeutic potential. To support this contention, the physical and mechanical properties, rheological characteristics, and component release of candidate formulations were investigated. An optimized formulation of COP-THB containing LDC to an upper maximum concentration of 1.5% w/w was assessed for drug crystallization. The biocompatibility of the prepared COP-THB hydrogel was exhibited strong cell survival (96%) and growth compatibility on L929 fibroblast cell lines, which was confirmed by using methods of MTT assay and microscopic observations. The COP-THB hydrogel release pattern is distinct from that of COP-THB/LDC hydrogels by the slow-release rate and the low percentage of cumulative release. In vivo evaluations were demonstrated the anesthetic effects and toxicity value of treated samples by using mice models. In addition, COP-THB/LDC hydrogels significantly inhibit in vivo tumor growth in mice model and effectively reduced it is in vivo toxicity. The pharmacological evaluation showed that encapsulation of LDC in COP-THB hydrogels prolonged its anesthetic action with favorable in vitro and in vivo compatibility. This novel design may theoretically be used in promising studies involving the controlled release of local anesthetics. HIGHLIGHTSDevelopment a modified sustained release system for the local anesthetic lidocaine. PVP-THB hydrogel to improve the pharmacological properties of the drug and their anesthetic activities. Profiles of PVP-THB/LDC showed that the effective release of associated lidocaine. This new formulation could potentially be used in future local anesthetics.

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“…Hou et al. [ 333 ] fabricated porous PCL scaffolds with interconnected cells by batch foaming PCL/PEO blends with supercritical carbon dioxide, followed by leaching out the PEO. An increase in PEO content resulted in decrease in the increase in the pore density.…”

Section: Foamability For Special Applicationsmentioning

confidence: 99%

Foamability and Special Applications of Microcellular Thermoplastic Polymers: A Review on Recent Advances and Future Direction

Banerjee¹,

Ray

2020

Macro Materials & Eng

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Figure 6. a) Schematic of underwater pelletization as a following unit of a foam extrusion system. For expandable beads, the water pressure is set above the vapor pressure of the blowing agent; for expanded, it lies at atmospheric pressure. b) Bead foam processing in a steam-chest molding machine: 1: closing and 2: filling the mold, 3: steaming, 4: cooling, 5: ejection of molded part. Reproduced with permission. [53] Copyright 2015, Elsevier.

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Fabrication of fibrillated and interconnected porous poly(ε-caprolactone) vascular tissue engineering scaffolds by microcellular foaming and polymer leaching

Abstract: This paper provides a method combining eco-friendly supercritical CO2 microcellular foaming and polymer leaching to fabricate small-diameter vascular tissue engineering scaffolds.

Cited by 29 publications

References 48 publications

Applications of Engineering Techniques in Microvasculature Design

Applications of Engineering Techniques in Microvasculature Design

Facile design of lidocaine-loaded polymeric hydrogel to persuade effects of local anesthesia drug delivery system: complete in vitro and in vivo toxicity analyses

Foamability and Special Applications of Microcellular Thermoplastic Polymers: A Review on Recent Advances and Future Direction

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