Fabrication of elastin additive on polymethyl methacrylate and hydroxyapatite-based bioactive bone cement

Rad, Matin Mohammadzadeh; Saber‐Samandari, Saeed; Bokov, Dmitry Olegovich; Suksatan, Wanich; Aghdam, M.M.; Esfahani, MH. Malekipour; Sadighi, Mojtaba; Yusof, Mohd Yusmiaidil Putera Mohd; El-Shafay, A.S.

doi:10.1016/j.matchemphys.2022.125783

Cited by 11 publications

(4 citation statements)

References 71 publications

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“…The fabricated bioactive materials exhibit desirable chemical structural and surface morphological behavior with suitable mechanical characteristics. Hence, the fabricated bioactive materials would be potential materials for bone tissue engineering applications …”

Section: Applications Of Protein In Bone Tissue Engineeringmentioning

confidence: 99%

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Current Perspectives of Protein in Bone Tissue Engineering: Bone Structure, Ideal Scaffolds, Fabrication Techniques, Applications, Scopes, and Future Advances

Aslam Khan,

Aslam,

Bin Abdullah

et al. 2024

ACS Appl. Bio Mater.

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In view of their exceptional approach, excellent inherent biocompatibility and biodegradability properties, and interaction with the local extracellular matrix, protein-based polymers have received attention in bone tissue engineering, which is a multidisciplinary field that repairs and regenerates fractured bones. Bone is a multihierarchical complex structure, and it performs several essential biofunctions, including maintaining mineral balance and structural support and protecting soft organs. Protein-based polymers have gained interest in developing ideal scaffolds as emerging biomaterials for bone fractured healing and regeneration, and it is challenging to design ideal bone substitutes as perfect biomaterials. Several protein-based polymers, including collagen, keratin, gelatin, serum albumin, etc., are potential materials due to their inherent cytocompatibility, controlled biodegradability, high biofunctionalization, and tunable mechanical characteristics. While numerous studies have indicated the encouraging possibilities of proteins in BTE, there are still major challenges concerning their biodegradability, stability in physiological conditions, and continuous release of growth factors and bioactive molecules. Robust scaffolds derived from proteins can be used to replace broken or diseased bone with a biocompatible substitute; proteins, being biopolymers, provide excellent scaffolds for bone tissue engineering. Herein, recent developments in protein polymers for cutting-edge bone tissue engineering are addressed in this review within 3−5 years, with a focus on the significant challenges and future perspectives. The first section discusses the structural fundamentals of bone anatomy and ideal scaffolds, and the second section describes the fabrication techniques of scaffolds. The third section highlights the importance of proteins and their applications in BTE. Hence, the recent development of protein polymers for state-of-the-art bone tissue engineering has been discussed, highlighting the significant challenges and future perspectives.

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Section: Applications Of Protein In Bone Tissue Engineeringmentioning

confidence: 99%

“…Hence, the fabricated bioactive materials would be potential materials for bone tissue engineering applications. 221 6.7. Serum Albumin.…”

Section: Gelatinmentioning

confidence: 99%

Current Perspectives of Protein in Bone Tissue Engineering: Bone Structure, Ideal Scaffolds, Fabrication Techniques, Applications, Scopes, and Future Advances

Aslam Khan,

Aslam,

Bin Abdullah

et al. 2024

ACS Appl. Bio Mater.

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“…The magnetic properties of these nanocatalysts enable easy separation and recovery using an external magnetic eld, which can optimize operational costs and improve the purity of the nal product. 7,8 One of the signicant types of magnetic nanoparticles owing to its excellent cubic magneto crystal is cobalt ferrite (CoFe 2 O 4 ). In catalysis, ferrites are said to be efficient materials.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of a green and recyclable arginine-based palladium/CoFe₂O₄ nanomagnetic catalyst for efficient cyanation of aryl halides

HajimohamadzadehTorkambour,

Nejad,

Pazoki

et al. 2024

RSC Adv.

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“…There is also research on the development of new composite bone cements based on PMMA matrix modified with, i.e., CaP, carbon nanotubes, amine-functionalized graphene, or borosilicate glass . Further, Rad et al developed bioactive cement based on three components: PMMA, elastin, and nanohydroxyapatite . Furthermore, there are also works on α-tricalcium phosphate cement combined with 2-hydroxyethyl methacrylate as representative of the dual-setting group. , In all scientific results from the articles mentioned above, attention was paid to the beneficial synergistic effect of ceramic-polymer cement hybrids.…”

Section: Introductionmentioning

confidence: 99%

Dual-Setting Bone Cement Based On Magnesium Phosphate Modified with Glycol Methacrylate Designed for Biomedical Applications

Wekwejt,

Khamenka,

Ronowska

et al. 2023

ACS Appl. Mater. Interfaces

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Magnesium phosphate cement (MPC) is a suitable alternative for the currently used calcium phosphates, owing to beneficial properties like favorable resorption rate, fast hardening, and higher compressive strength. However, due to insufficient mechanical properties and high brittleness, further improvement is still expected. In this paper, we reported the preparation of a novel type of dual-setting cement based on MPC with poly(2-hydroxyethyl methacrylate) (pHEMA). The aim of our study was to evaluate the effect of HEMA addition, especially its concentration and premix time, on the selected properties of the composite. Several beneficial effects were found: better formability, shortened setting time, and improvement of mechanical strengths. The developed cements were hardening in ∼16–21 min, consisted of well-crystallized phases and polymerized HEMA, had porosity between ∼2–11%, degraded slowly by ∼0.1–4%/18 days, their wettability was ∼20–30°, they showed compressive and bending strength between ∼45–73 and 13–20 MPa, respectively, and, finally, their Young’s Modulus was close to ∼2.5–3.0 GPa. The results showed that the optimal cement composition is MPC+15%HEMA and 4 min of polymer premixing time. Overall, our research suggested that this developed cement may be used in various biomedical applications.

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Fabrication of elastin additive on polymethyl methacrylate and hydroxyapatite-based bioactive bone cement

Cited by 11 publications

References 71 publications

Current Perspectives of Protein in Bone Tissue Engineering: Bone Structure, Ideal Scaffolds, Fabrication Techniques, Applications, Scopes, and Future Advances

Current Perspectives of Protein in Bone Tissue Engineering: Bone Structure, Ideal Scaffolds, Fabrication Techniques, Applications, Scopes, and Future Advances

Synthesis and characterization of a green and recyclable arginine-based palladium/CoFe₂O₄ nanomagnetic catalyst for efficient cyanation of aryl halides

Dual-Setting Bone Cement Based On Magnesium Phosphate Modified with Glycol Methacrylate Designed for Biomedical Applications

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Fabrication of elastin additive on polymethyl methacrylate and hydroxyapatite-based bioactive bone cement

Cited by 11 publications

References 71 publications

Current Perspectives of Protein in Bone Tissue Engineering: Bone Structure, Ideal Scaffolds, Fabrication Techniques, Applications, Scopes, and Future Advances

Current Perspectives of Protein in Bone Tissue Engineering: Bone Structure, Ideal Scaffolds, Fabrication Techniques, Applications, Scopes, and Future Advances

Synthesis and characterization of a green and recyclable arginine-based palladium/CoFe2O4 nanomagnetic catalyst for efficient cyanation of aryl halides

Dual-Setting Bone Cement Based On Magnesium Phosphate Modified with Glycol Methacrylate Designed for Biomedical Applications

Contact Info

Product

Resources

About

Synthesis and characterization of a green and recyclable arginine-based palladium/CoFe₂O₄ nanomagnetic catalyst for efficient cyanation of aryl halides