Fabrication of effective mesoporous silica materials for emergency hemostasis application

Zhang, Zhuoran; Liu, Tao; Qi, Zenghua; Li, Fan; Yang, Kun; Ding, Shan; Lin, Song; Tian, Faming

doi:10.1007/s12633-021-01648-6

Cited by 10 publications

(4 citation statements)

References 40 publications

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“…In-situ synthesis of mesoporous silica-cotton (MSÀ C) composite is another type of modified hemostatic material that can be used in emergency hemostasis applications. Zhang et al [168] revealed that (MSÀ C) has the advantages of excellent hemo-static performance, strong adsorption, flexible structure, good biological safety, and low cost. Furthermore, MSP's whole blood clotting time was approximately 23.13% shorter than the in vitro clotting time of Celox™ Granules (chitosan powder).…”

Section: Mesoporous Silica In Hemorrhage Controlmentioning

confidence: 99%

Comprehensive Review of Mesoporous Silica Nanoparticles: Drug Loading, Release, and Applications as Hemostatic Agents

Albayati,

Alardhi,

Khalbas

et al. 2024

ChemistrySelect

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Recently, mesoporous silica nanoparticles (MSNs) have emerged as promising candidates in the field of hemorrhage control owing to their extended pore size, high surface area, and excellent biocompatibility. These characteristics directly influence the toxicity of cells, the loading of therapeutic agents, and the release of active ions during the hemostasis process. Therefore, understanding the fundamentals of tuning these characteristics is important to design these types of carriers. While several literature reviews have explored the role of MSNs in hemorrhage control, comprehensive studies focusing on their general characteristics and specific applications remain scarce. This review concentrates on the principles of synthesizing mesoporous silica, the general types of MSNs, techniques for loading drugs methods onto the site of injury, release kinetics models, biocompatibility, toxicity, and the unique properties of MSNs. Furthermore, the article examines the mechanism of action of MSNs as nanomaterial hemostatic agents.

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Section: Mesoporous Silica In Hemorrhage Controlmentioning

confidence: 99%

Comprehensive Review of Mesoporous Silica Nanoparticles: Drug Loading, Release, and Applications as Hemostatic Agents

Albayati,

Alardhi,

Khalbas

et al. 2024

ChemistrySelect

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“…Notably, this modied-cotton showed a shorter blood clotting time (86.00 s) and less blood loss (0.02 g) in vivo. 157 3.4.2 Membrane composite. Inspired by battleeld bandage, many inorganic-polymer composite membrane materials have also been developed.…”

Section: Inorganic-polymer Composite Hemostatic Materialsmentioning

confidence: 99%

“…Notably, this modified-cotton showed a shorter blood clotting time (86.00 s) and less blood loss (0.02 g) in vivo . 157 …”

Section: Inorganic-based Biomaterials For Rapid Hemostasismentioning

confidence: 99%

Inorganic-based biomaterials for rapid hemostasis and wound healing

Zhu

et al. 2023

Chem. Sci.

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“…Different applications require different 3D modifications of composites architectures. For example, for the materials with antimicrobial protection, thin films or sponges are suitable to ensure the best fit to the wound or to introduce the additional hemostatic properties in the material [ 41 , 42 ]. In the tasks of water purification from microbial contamination, porous sponges or capsules are needed, which can be removed from the solution after use.…”

Section: Introductionmentioning

confidence: 99%

Water Saturated with Pressurized CO2 as a Tool to Create Various 3D Morphologies of Composites Based on Chitosan and Copper Nanoparticles

et al. 2022

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Methods for creating various 3D morphologies of composites based on chitosan and copper nanoparticles stabilized by it in carbonic acid solutions formed under high pressure of saturating CO2 were developed. This work includes a comprehensive analysis of the regularities of copper nanoparticles stabilization and reduction with chitosan, studied by IR and UV-vis spectroscopies, XPS, TEM and rheology. Chitosan can partially reduce Cu2+ ions in aqueous solutions to small-sized, spherical copper nanoparticles with a low degree of polydispersity; the process is accompanied by the formation of an elastic polymer hydrogel. The resulting composites demonstrate antimicrobial activity against both fungi and bacteria. Exposing the hydrogels to the mixture of He or H2 gases and CO2 fluid under high pressure makes it possible to increase the porosity of hydrogels significantly, as well as decrease their pore size. Composite capsules show sufficient resistance to various conditions and reusable catalytic activity in the reduction of nitrobenzene to aniline reaction. The relative simplicity of the proposed method and at the same time its profound advantages (such as environmental friendliness, extra purity) indicate an interesting role of this study for various applications of materials based on chitosan and metals.

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Fabrication of effective mesoporous silica materials for emergency hemostasis application

Cited by 10 publications

References 40 publications

Comprehensive Review of Mesoporous Silica Nanoparticles: Drug Loading, Release, and Applications as Hemostatic Agents

Comprehensive Review of Mesoporous Silica Nanoparticles: Drug Loading, Release, and Applications as Hemostatic Agents

Inorganic-based biomaterials for rapid hemostasis and wound healing

Water Saturated with Pressurized CO2 as a Tool to Create Various 3D Morphologies of Composites Based on Chitosan and Copper Nanoparticles

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