Fabrication of ECM protein coated hollow collagen channels to study peripheral nerve regeneration
Jarin Tusnim,
Karthik Budharaju,
Jonathan M. Grasman
Abstract:Peripheral nerve injury is a prevalent clinical problem that often leads to lifelong disability and reduced quality of life. Although peripheral nerves can regenerate, recovery after severe injury is slow and incomplete. The current gold standard treatment, autologous nerve transplantation, has limitations including donor site morbidity and poor functional outcomes, highlighting the need for improved repair strategies. We developed a reproducible in vitro hollow channel collagen gel construct to investigate pe… Show more
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