Fabrication of dopamine enveloped WO3−x quantum dots as single-NIR laser activated photonic nanodrug for synergistic photothermal/photodynamic therapy against cancer

Sheng, Jianping; Zhang, Ling; Liu, You‐Nian; Han, Yuge; Wang, Liqiang; He, Haichuan

doi:10.1016/j.cej.2019.123071

Cited by 47 publications

(17 citation statements)

References 38 publications

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“…It is noticeable that no NIR-irradiation did not trigger photocatalytic reactions and consequently did not cause toxicity to normal organs, and there was no toxic side effects of drug because no drug was used, reflecting the incomparable advantages of drug-free therapy in biosafety. Additionally, the toxicity of tungsten as a heavy metal is mainly demonstrated by soluble tungstates rather than by relatively more stable tungsten oxide and metal tungsten [40][41][42][43][44][45][46][47][48] , and therefore the development of tungsten oxide for biomedical applications is broadly being studies [42][43][44][45][46][47][48] where high biocompatibility with lowest toxic dose of 1000 mg/kg for oral administration was demonstrated. In this work, we also found that neither WO 3 nor SnS 1.68 -WO 2.41 exhibited obvious cytotoxicity (600 μg/mL, Supplementary Fig.…”

Section: Resultsmentioning

confidence: 99%

Photocatalysis-mediated drug-free sustainable cancer therapy using nanocatalyst

et al. 2021

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Drug therapy unavoidably brings toxic side effects and drug content-limited therapeutic efficacy although many nanocarriers have been developed to improve them to a certain extent. In this work, a concept of drug-free therapeutics is proposed and defined as a therapeutic methodology without the use of traditional toxic drugs, without the consumption of therapeutic agents during treatment but with the inexhaustible therapeutic capability to maximize the benefit of treatment, and a Z-scheme SnS1.68-WO2.41 nanocatalyst is developed to achieve near infrared (NIR)-photocatalytic generation of oxidative holes and hydrogen molecules for realizing combined hole/hydrogen therapy by the drug-free therapeutic strategy. Without the need of any drug and other therapeutic agent assistance, the nanocatalyst oxidizes/consumes intratumoral over-expressed glutathione (GSH) by holes and simultaneously generates hydrogen molecules in a lasting and controllable way under NIR irradiation. Mechanistically, generated hydrogen molecules and GSH consumption inhibit cancer cell energy and destroy intratumoral redox balance, respectively, to synergistically damage DNA and induce tumor cell apoptosis. High efficacy and biosafety of combined hole/hydrogen therapy of tumors are achieved by the nanocatalyst. The proposed catalysis-based drug-free therapeutic strategy breaks a pathway to realize high efficacy and low toxicity of cancer treatment.

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Section: Resultsmentioning

confidence: 99%

Photocatalysis-mediated drug-free sustainable cancer therapy using nanocatalyst

et al. 2021

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“…Additionally, in vivo application was examined on male BALB/c mice bearing subcutaneous 4T1 murine breast cancer tumors to evaluate PDT of WO 3 ‐x/Dpa‐Mel NPs. The results showed that WO 3 ‐x/Dpa‐Mel NPs can create an excellent synergistic phototherapy effect on solid tumor ablation in vivo without damaging healthy tissues under the light irradiation (134).…”

Section: Tungstenmentioning

confidence: 99%

Photodynamic Therapy of Inorganic Complexes for the Treatment of Cancer^†

Smith

Days

Alajroush

et al. 2021

Photochem & Photobiology

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Photodynamic therapy (PDT) is a medicinal tool that uses a photosensitizer and a light source to treat several conditions, including cancer. PDT uses reactive oxygen species such as cytotoxic singlet oxygen (1O2) to induce cell death in cancer cells. Chemotherapy has historically utilized the cytotoxic effects of many metals, especially transition metal complexes. However, chemotherapy is a systemic treatment so all cells in a patient’s body are exposed to the same cytotoxic effects. Transition metal complexes have also shown high cytotoxicity as PDT agents. PDT is a potential localized method for treating several cancer types by using inorganic complexes as photosensitizing agents. This review covers several in vitro and in vivo studies, as well as clinical trials that reported on the anticancer properties of inorganic pharmaceuticals used in PDT against different types of cancer.

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“…As a result, the tumor hypoxia has posed a big obstacle for PDT [ 16 , 25 ]. Notably, the combination of PDT and PTT can achieve complementary advantages [ 26 ]. On the one hand, tumor-localized temperature rise via PTT can not only induce tumor cell apoptosis but also improve the blood perfusion at the tumor site, which could significantly relieve tumor hypoxia, thus facilitating the therapeutic efficacy of PDT [ 16 , 27 ].…”

Section: Introductionmentioning

confidence: 99%

Erythrocyte membrane-camouflaged carrier-free nanoassembly of FRET photosensitizer pairs with high therapeutic efficiency and high security for programmed cancer synergistic phototherapy

Zhang

Xiong

Wang

et al. 2021

Bioactive Materials

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Phototherapy has been intensively investigated as a non-invasive cancer treatment option. However, its clinical translation is still impeded by unsatisfactory therapeutic efficacy and severe phototoxicity. To achieve high therapeutic efficiency and high security, a nanoassembly of Forster Resonance Energy Transfer (FRET) photosensitizer pairs is developed on basis of dual-mode photosensitizer co-loading and photocaging strategy. For proof-of-concept, an erythrocyte-camouflaged FRET pair co-assembly of chlorine e6 (Ce6, FRET donor) and 1,1′-dioctadecyl-3,3,3′,3′-tetramethylindotricarbocyanine iodide (DiR, FRET acceptor) is investigated for breast cancer treatment. Notably, Ce6 in the nanoassemby is quenched by DiR and could be unlocked for photodynamic therapy (PDT) only when DiR is photobleached by 808-nm laser. As a result, Ce6-caused phototoxicity could be well controlled. Under cascaded laser irradiation (808–660 nm), tumor-localizing temperature rise following laser irradiation on DiR not only induces tumor cell apoptosis but also facilitates the tumor penetration of NPs, relieves tumor hypoxia, and promotes the PDT efficacy of Ce6. Such FRET pair-based nanoassembly provides a new strategy for developing multimodal phototherapy nanomedicines with high efficiency and good security.

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Fabrication of dopamine enveloped WO3−x quantum dots as single-NIR laser activated photonic nanodrug for synergistic photothermal/photodynamic therapy against cancer

Cited by 47 publications

References 38 publications

Photocatalysis-mediated drug-free sustainable cancer therapy using nanocatalyst

Photocatalysis-mediated drug-free sustainable cancer therapy using nanocatalyst

Photodynamic Therapy of Inorganic Complexes for the Treatment of Cancer^†

Erythrocyte membrane-camouflaged carrier-free nanoassembly of FRET photosensitizer pairs with high therapeutic efficiency and high security for programmed cancer synergistic phototherapy

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Fabrication of dopamine enveloped WO3−x quantum dots as single-NIR laser activated photonic nanodrug for synergistic photothermal/photodynamic therapy against cancer

Cited by 47 publications

References 38 publications

Photocatalysis-mediated drug-free sustainable cancer therapy using nanocatalyst

Photocatalysis-mediated drug-free sustainable cancer therapy using nanocatalyst

Photodynamic Therapy of Inorganic Complexes for the Treatment of Cancer†

Erythrocyte membrane-camouflaged carrier-free nanoassembly of FRET photosensitizer pairs with high therapeutic efficiency and high security for programmed cancer synergistic phototherapy

Contact Info

Product

Resources

About

Photodynamic Therapy of Inorganic Complexes for the Treatment of Cancer^†