Fabrication of dihydroxyflavone-conjugated hyaluronic acid nanogels for targeted antitumoral effect

Choi, Yongju; Kim, Hyun-Jong; Ahn, Guk Young; Lee, Min Jeong; Park, Ju Ri; Jun, Dae-Ryong; Ryu, Tae-Kyoung; Park, Joo Woong; Shin, Eunji; Choi, Sung‐Wook

doi:10.1016/j.colsurfb.2018.08.003

Cited by 17 publications

(10 citation statements)

References 19 publications

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“…It is likely that HA plays a role in the selective uptake. The CD44 receptor, which is a hyaluronan receptor, is significantly more abundant on the surface of HepG2 cells than on L02 cells. − A CCK-8 cytotoxicity assay indicated that the cell viability after 24 h of incubation for both cell lines was unaffected by the MMH nanoconjugates up to 200 μg/mL (Figure S23, Supporting Information). The cell viability was also not significantly affected by free luminol, up to a concentration of 100 μM after 48 h of incubation (Figure S24, Supporting Information).…”

Section: Resultsmentioning

confidence: 99%

Self-Illuminated, Oxygen-Supplemented Photodynamic Therapy via a Multienzyme-Mimicking Nanoconjugate

Yin

Liu

Zhang

et al. 2021

ACS Appl. Bio Mater.

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Current photodynamic therapy (PDT) faces several intrinsic limitations, including insufficient oxygen supply and limited penetration of external light sources. Herein, we report a nanoconjugate, which, in response to the elevated hydrogen peroxide levels associated with tumor tissues, can supplement the oxygen needed for PDT and provide local self-illumination. Consisting of a MnFe2O4 core, a metal–organic framework shell loaded with the chemiluminescence reagent luminol, and a hyaluronic acid surface coating, the nanoconjugate is highly effective for suppressing cancer tissues in vivo via PDT in the absence of externally delivered light.

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Section: Resultsmentioning

confidence: 99%

Self-Illuminated, Oxygen-Supplemented Photodynamic Therapy via a Multienzyme-Mimicking Nanoconjugate

Yin

Liu

Zhang

et al. 2021

ACS Appl. Bio Mater.

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“…Another advantages of drug conjugation are increased water solubility of drugs in physiologic environments, increased hydrodynamic volume, decreased renal filtration, aggregation, enzyme degradation and immunogenicity [80]. In a study conducted by Choi et al (2018) dihydroxyflavone (DHF)conjugated HA (HA-DHF) nanogels were reported with controllable particle size from 246 to 615 by changing the ratio of crosslinker 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride (DMTMM) which was used in both crosslinking of HA units and DHF conjugation to nanogel backbone [81]. The HA-DHF nanogels were proven to achieve targeted delivery of DHF to HeLa and HepG2 cancer cell lines and accomplished 40% reduction in cell viability while they were not toxic to normal NIH3T3 cells.…”

Section: Drug Loading By Chemical Conjugationmentioning

confidence: 99%

Micro and Nanogels for Biomedical Applications

Can

Güven

Şahiner

2020

Hacettepe Journal of Biology and Chemistry

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D oğal ve sentetik polimerlerden geliştirilen mikro ve nano hidrojeller, yüksek yüzey alanı, yüksek derecede şişme, yüksek aktif madde yükleme kapasiteleri, yumuşaklık esneklik ve doğal dokulara benzerlikleri nedeniyle bilimsel ve endüstriyel alanda büyük ilgi görmüştür. Özellikle, biyouyumlu, toksik olmayan ve biyobozunur mikro/nano taşıyıcıların uygulamaya özgü tasarım ve fonksiyonelleştirilebilme olanakları, doku mühendisliği, biyo görüntüleme ve ilaç taşıma/teslim uygulamaları gibi çeşitli biyomedikal uygulamalar için mükemmel bir fizibilite sunmaktadır. Bununla birlikte, bu platformların in vivo ortamlardaki biyolojik bariyerleri aşabilmesi ve klinik uygulamalarda kullanıma girebilmesi için rasyonel tasarım ve işlevselleştirme stratejileri gerekmektedir. İlk olarak, ideal bir taşıyıcı biyo-uyumlu olmalı ve bağışıklık sisteminin eliminasyonundan kaçabilmeli, özellikle de istenen bölgeleri hedeflemeli ve ortam koşullarına duyarlı olarak terapötik yükü sürdürülebilir bir şekilde salabilmelidir. Mikro/nano materyal tasarımında küçük sorunlara rağmen klinik kullanıma giren birkaç başarılı formülasyon mevcuttur ve bu taşıyıcıların çoğu, tüm biyolojik kriterler için henüz tam bir başarı sağlayamamışlardır. Bu derlemede, mikro ve nanojellerin tasarım ve işlevselleştirme stratejileri özetlenerek mikro-ve nanojellerin biyomedikal uygulamalarındaki son gelişmeler, ilaç ve biyomolekül salım uygulamalarına ağırlık vererek özetlenmiştir.

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“…Dihydroxyflavone‐conjugated hyaluronic acid nanogels were prepared and tested for cellular uptake and antitumoral efficiency. The smaller nanogels were taken up by two kinds of tumor cells (HeLa and HepG2) (Choi et al, ). Adamantane‐grafted hyaluronic acid can work as carrier for methyl‐β‐cyclodextrin through supramolecular assembly and proved to be a potential antitumor agent (Elamin, Yamashita, Higashi, Motoyama, & Arima, ).…”

Section: Polysaccharidesmentioning

confidence: 99%

Carbohydrate‐based nanomaterials for biomedical applications

Gim

Zhu

Seeberger

et al. 2019

WIREs Nanomed Nanobiotechnol

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Carbohydrates are abundant biomolecules, with a strong tendency to form supramolecular networks. A host of carbohydrate-based nanomaterials have been exploited for biomedical applications. These structures are based on simple monoor disaccharides, as well as on complex, polymeric systems. Chemical modifications serve to tune the shapes and properties of these materials. In particular, carbohydrate-based nanoparticles and nanogels were used for drug delivery, imaging, and tissue engineering applications. Due to the reversible nature of the assembly, often based on a combination of hydrogen bonding and hydrophobic interactions, carbohydrate-based materials are valuable substrates for the creations of responsive systems. Herein, we review the current research on carbohydratebased nanomaterials, with a particular focus on carbohydrate assembly. We will discuss how these systems are formed and how their properties are tuned. Particular emphasis will be placed on the use of carbohydrates for biomedical applications.

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Fabrication of dihydroxyflavone-conjugated hyaluronic acid nanogels for targeted antitumoral effect

Cited by 17 publications

References 19 publications

Self-Illuminated, Oxygen-Supplemented Photodynamic Therapy via a Multienzyme-Mimicking Nanoconjugate

Self-Illuminated, Oxygen-Supplemented Photodynamic Therapy via a Multienzyme-Mimicking Nanoconjugate

Micro and Nanogels for Biomedical Applications

Carbohydrate‐based nanomaterials for biomedical applications

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