Fabrication of Defined Polydopamine Nanostructures by DNA Origami‐Templated Polymerization

Tokura, Yu; Harvey, Sean; Chen, Chaojian; Wu, Yuzhou; Ng, David Y. W.; Weil, Tanja

doi:10.1002/anie.201711560

Cited by 106 publications

(117 citation statements)

References 42 publications

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“…After polymerization, the PDA nanostructures can be liberated in acidic medium. [44] The application of microplasma anodic oxidation allowed to regulate the polymerization of DA resulting in fluorescent nanoparticles in a few minutes without aggregation. [45] For coating of surfaces electrodeposition, i.e.…”

Section: Synthesis Methods For Pdamentioning

confidence: 99%

Chemistry of Polydopamine – Scope, Variation, and Limitation

2019

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Polydopamine (PDA) is a polymer easily obtained by oxidation of dopamine. It is composed of indole and dopamine units in various oxidation states and to a lesser extent of pyrroles. It adheres to all type of surfaces even under water due to its abundant catechol moieties assisted by amino groups. This property together with a widespread reactivity to nucleophiles and electrophiles allowing linkage of a variety of entities renders PDA extremely interesting for various applications in biology, biomedicine, membranes, catalysis, materials and water purification. The field of PDA is violently developing. The present review gives an overview about the chemistry and properties of PDA and its analogues with the focus on recent publications. Their widespread applications are occasionally touched. Analogues are obtained by two strategies: post‐modification of PDA and oxidative polymerization of dopamine analogues. Scope and limitations of these strategies are worked out giving impulses for future research in the field.

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Section: Synthesis Methods For Pdamentioning

confidence: 99%

Chemistry of Polydopamine – Scope, Variation, and Limitation

2019

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“…Upon the light‐triggered ROS generation by PPIX and subsequent dopamine oxidation, reaction progress was monitored by recording UV/Vis spectra, tracking the increase of oxidized species (dopaminochrome), precursor oligomers, and polydopamine (Figure B) . Initially, oxidation of dopamine to dopaminochrome and ongoing oligomer formation was observed, followed by the emergence of polymeric components.…”

Section: Figurementioning

confidence: 99%

Photocontrolled Dopamine Polymerization on DNA Origami with Nanometer Resolution

Winterwerber

Harvey

et al. 2019

Angew Chem Int Ed

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Temporal and spatial control over polydopamine formation on the nanoscale can be achieved by installing an irradiation‐sensitive polymerization system on DNA origami. Precisely distributed G‐quadruplex structures on the DNA template serve as anchors for embedding the photosensitizer protoporphyrin IX, which—upon irradiation with visible light—induces the multistep oxidation of dopamine to polydopamine, producing polymeric structures on designated areas within the origami framework. The photochemical polymerization process allows exclusive control over polydopamine layer formation through the simple on/off switching of the light source. The obtained polymer–DNA hybrid material shows significantly enhanced stability, paving the way for biomedical and chemical applications that are typically not possible owing to the sensitivity of DNA.

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“…[16,17] For example, anisotropic PDA nanostructures with distinct shapes were createdu sing DNA origami templated polymerization with G4/hemin based DNA nanotiles as templates. [18] Sacrificial mesoporous silica template wasu sed for creatingh ollow nanocapsuleso fP DA. [19] Curcuminc rystals and ZnO nanorodsw ere utilized as templates to create PDA nanotubes.…”

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confidence: 99%

Chirally Twisted Ultrathin Polydopamine Nanoribbons: Synthesis and Spontaneous Assembly of Silver Nanoparticles on Them

Awasthi

Bhagat

Ramakrishnan

et al. 2019

Chemistry A European J

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Polydopamine (PDA) is a synthetic polymeric material with immense potential in biomedical and surface functionalization applications. Herein, we have screened self‐assemblies formed by Phenylalanine‐based amphiphiles (Phe‐AMPs) as soft templates for preparing chiral PDA nanostructures. Our study revealed that the amphiphile 2 endowed with a primary amine residue afforded chirally‐twisted ultrathin nanoribbons of PDA under optimized conditions. The chirality at the Phe residue of 2 modulated the twist‐chirality of the PDA nanoribbons; the l‐2 resulted in nanoribbons with right‐handed twist, whereas the d‐2 induced a left‐handed twist to the ribbons. The racemic mixture of these two amphiphiles produced flat, achiral tapes. The PDA ribbon thickness was ≈5.86±0.40 nm, whereas its width and length were ≈133.5±3.2 nm and >5000 nm, respectively. Upon dialysis, hollow PDA nanotubes were obtained due to curling of the PDA nanoribbons. These PDA‐nanoarchitectures were employed to spontaneously form and assemble Ag‐nanoparticles along the edges of the PDA nanoribbons. In this work we are reporting chirality controlled synthesis of PDA nanostructures for the first time.

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Fabrication of Defined Polydopamine Nanostructures by DNA Origami‐Templated Polymerization

Cited by 106 publications

References 42 publications

Chemistry of Polydopamine – Scope, Variation, and Limitation

Chemistry of Polydopamine – Scope, Variation, and Limitation

Photocontrolled Dopamine Polymerization on DNA Origami with Nanometer Resolution

Chirally Twisted Ultrathin Polydopamine Nanoribbons: Synthesis and Spontaneous Assembly of Silver Nanoparticles on Them

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