Fabrication of custom PCL scaffold for nasal septal perforation repair

Gadaleta, Dominick; Lee, Daniel Z.; Peng, Matthew W.; Cruickshank, Nicholas; Shinde, Rohit; Hong, Abigail L.; Pennacchi, Sara; Dawit, Abel; Krein, Howard; Udupa, Jayaram K.; Rajapakse, Chamith S.

doi:10.1117/12.2293820

Cited by 2 publications

(2 citation statements)

References 3 publications

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“…Another reconstructive application of 3DP is the repair of nasal septal perforations. Currently, septal perforations are typically repaired with an implanted graft, often composed of autologous cartilage (i.e., auricular cartilage) or synthetic material, sandwiched between bilateral mucoperichondrial flaps [27]. Given the limited vascular supply in the area, grafts greater than 2 cm often have low success rates requiring larger reconstructions using local or free flaps.…”

Section: D Printingmentioning

confidence: 99%

“…The PCL scaffold thickness was based on the average thickness of the septum and maintained constant throughout the structure. The scaffolds were not implanted, but they could theoretically be seeded with cells to introduce cartilage growth at the site of the defect [27]. These surgeons were able to recreate the sagittal shape of the defect based on patient imaging.…”

Section: D Printingmentioning

confidence: 99%

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The Creation of an Average 3D Model of the Human Cartilaginous Nasal Septum and Its Biomimetic Applications

Han,

Punjabi,

Goese

et al. 2023

Biomimetics

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The cartilaginous nasal septum is integral to the overall structure of the nose. Developing our an-atomic understanding of the septum will improve the planning and techniques of septal surgeries. While the basic dimensions of the septum have previously been described, the average shape in the sagittal plane has yet to be established. Furthermore, determining the average shape allows for the creation of a mean three-dimensional (3D) septum model. To better understand the average septal shape, we dissected septums from 40 fresh human cadavers. Thickness was measured across pre-defined points on each specimen. Image processing in Photoshop was used to superimpose lateral photographs of the septums to determine the average shape. The average shape was then combined with thickness data to develop a 3D model. This model may be utilized in finite elemental analyses, creating theoretical results about septal properties that are more translatable to real-world clinical practice. Our 3D septum also has numerous applications for 3D printing. Realistic models can be created for educational or surgical planning purposes. In the future, our model could also serve as the basis for 3D-printed scaffolds to aid in tissue regeneration to reconstruct septal defects. The model can be viewed at the NIH 3D model repository (3DPX ID: 020598, Title: 3D Nasal Septum).

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Section: D Printingmentioning

confidence: 99%

Section: D Printingmentioning

confidence: 99%