Fabrication of Cu−CeO₂ Coated Multiwall Carbon Nanotube Composite Electrode for Simultaneous Determination of Guanine and Adenine

Abstract

A copper nano particles and cerium (IV) oxide modified carbon nanotube based composite on glassy carbon electrode (Cu−CeO2/MWCNT/GCE) was fabricated for simultaneous determination of guanine and adenine. The surface morphology, chemistry and conductance of the prepared electrodes were characterized by scanning electron microscopy (SEM), energy dispersion X‐ray (EDX), X‐Ray photoelectron spectroscopy (XPS) and electrochemical impedance spectroscopy (EIS). The Cu−CeO2/MWCNT/GCE improved electrochemical behaviour of guanine and adenine compared to other electrodes. The modified electrode was also used for individual and simultaneous determination of guanine and adenine. Under optimized conditions, the calibration curves were obtained linearly in the range of 0.20 to 6.00 μM for the guanine and 0.10 to 8.0 μM for the adenine by differential pulse voltammetry. The limits of detection of guanine and adenine were calculated as 0.128 and 0.062 μM, respectively. Interferences studies were also performed in the presence of inorganic and organic compounds. Moreover, the determination of guanine and adenine contents were carried out in a calf thymus DNA sample by the developed method with satisfactory results.

Carbon Nanotube‐phenolic Resin Composite Electrode Fabricated by Far Infrared‐assisted Crosslinking for Enhanced Amperometric Detection

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“…Because it owns unique nanostructures and promising properties of physics and chemistry, it has find a wide range of scientific and technological applications, such as sensors, electronics, energy storage and biomedicine . Because of its high electrical conductivity, high specific area and electrocatalytic activity, CNT has been employed to prepare a variety of electrochemical sensors and biosensors with improved performances .…”

“…CNT‐based electrochemical sensors and biosensors are mainly fabricated by surface modification . Drop coating was the most commonly used approach.…”

Synthesis of MnCo2O4 nanoparticles as modifiers for simultaneous determination of Pb(II) and Cd(II)

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Simultaneous Determination of Antioxidants in Edible Oils Using Graphene Oxide/β‐Cyclodextrin‐modified Electrochemical Sensor

“…For decades, the application of nanomaterials in electrochemical sensors has drawn more and more attention, including molecularly imprinted polymers , metal nanotube or metal nanoparticles , carbon nanotube , functionalized polymers . However, those materials have their disadvantages in certain aspects, such as the weaker stability of antibody, the application restriction of molecularly imprinted polymers, the higher expense of raw materials and difficult to prepare.…”