Fabrication of copper ions-substituted hydroxyapatite/polydopamine nanocomposites with high antibacterial and angiogenesis effects for promoting infected wound healing

Tao, Bailong; Lin, Changjian; Guo, Ai; Yu, Yu; Qin, Xian; Li, Kai; Tian, Hongchuan; Yi, Weiwei; Lei, Dengliang; Chen, Lixue

doi:10.1016/j.jiec.2021.08.035

Cited by 35 publications

(18 citation statements)

References 58 publications

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“…PDAs have been proven to possess negligible toxicity when compared to metals, and also good biocompatibility which is confirmed by their nature, that can be likened to melanin [ 50 , 216 ]. HA-Cu/PDA exhibited good biocompatibility enabling collagen deposition and granulation formation for wound healing [ 207 ]. Also, colistin-loaded PDA with silver displayed good biocompatibility and negligible toxicity.…”

Section: Cytotoxicity and Biocompatibilitymentioning

confidence: 99%

Polydopamine, harness of the antibacterial potentials-A review

Obeng

Sun

et al. 2022

Materials Today Bio

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Section: Cytotoxicity and Biocompatibilitymentioning

confidence: 99%

Polydopamine, harness of the antibacterial potentials-A review

Obeng

Sun

et al. 2022

Materials Today Bio

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“…Although apatite offers benefits as a biomaterial implant, it can affect the proliferation rate of osteoblasts and the expression of cytokine genes [ 26 , 27 ]. However, pure apatite dry powder lacks an antibacterial mechanism.…”

Section: Introductionmentioning

confidence: 99%

“…When an infection occurs after surgery, pathogenic bacteria rapidly aggregate to form a biofilm, which strengthens the bacteria’s defense against the host and produces drug resistance. Appropriate antibiotic prophylaxis reduces the risk of postoperative wound infection, but antibiotics are becoming increasingly ineffective as resistance spreads globally [ 27 ]. As a result, treating infections and preventing deaths becomes challenging.…”

Section: Introductionmentioning

confidence: 99%

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Morphological Changes, Antibacterial Activity, and Cytotoxicity Characterization of Hydrothermally Synthesized Metal Ions-Incorporated Nanoapatites for Biomedical Application

et al. 2022

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The objective of this study was to prepare hydroxyapatite (HA) with potential antibacterial activity against gram-negative and gram-positive bacteria by incorporating different atomic ratios of Cu2+ (0.1–1.0%), Mg2+ (1.0–7.0%), and Zn2+ (1.0–7.0%) to theoretically replace Ca2+ ions during the hydrothermal synthesis of grown precipitated HA nanorods. This study highlights the role of comparing different metal ions on synthetic nanoapatite in regulating the antibacterial properties and toxicity. The comparisons between infrared spectra and between diffractograms have confirmed that metal ions do not affect the formation of HA phases. The results show that after doped Cu2+, Mg2+, and Zn2+ ions replace Ca2+, the ionic radius is almost the same, but significantly smaller than that of the original Ca2+ ions, and the substitution effect causes the lattice distance to change, resulting in crystal structure distortion and reducing crystallinity. The reduction in the length of the nanopatites after the incorporation of Cu2+, Mg2+, and Zn2+ ions confirmed that the metal ions were mainly substituted during the growth of the rod-shape nanoapatite Ca2+ distributed along the longitudinal site. The antibacterial results show that nanoapatite containing Cu2+ (0.1%), Mg2+ (3%), and Zn2+ (5–7%) has obvious and higher antibacterial activity against gram-positive bacteria Staphylococcus aureus within 2 days. The antibacterial effect against the gram-negative bacillus Escherichia coli is not as pronounced as against Staphylococcus aureus. The antibacterial effect of Cu2+ substituted Ca2+ with an atomic ratio of 0.1~1.0% is even better than that of Mg2+- and Zn2+- doped with 1~7% groups. In terms of cytotoxicity, nanoapatites with Cu2+ (~0.2%) exhibit cytotoxicity, whereas Mg2+- (1–5%) and Zn2+- (~1%) doped nanoapatites are biocompatible at low concentrations but become cytotoxic as ionic concentration increases. The results show that the hydrothermally synthesized nanoapatite combined with Cu2+ (0.2%), Mg2+ (3%), and Zn2+ (3%) exhibits low toxicity and high antibacterial activity, which provides a good prospect for bypassing antibiotics for future biomedical applications.

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“…[ 3 ]. HAp is the most widely used material for different biomedical applications, such as dermal filler [ 4 ], wound healing [ 5 ], scaffolds [ 6 , 7 , 8 ], biomedical coating [ 9 ], tissue engineering [ 10 ], and bone regeneration application [ 11 , 12 ]. Even though HAp is widely used, its usage for surgical purposes in implantation is limited due to bacterial infection.…”

Section: Introductionmentioning

confidence: 99%

Citric Acid-Mediated Microwave-Hydrothermal Synthesis of Mesoporous F-Doped HAp Nanorods from Bio-Waste for Biocidal Implant Applications

Karunakaran

Cho

Kumar³

et al. 2022

Nanomaterials

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In this current research, mesoporous nano-hydroxyapatite (HAp) and F-doped hydroxyapatite (FHAp) were effectively obtained through a citric acid-enabled microwave hydrothermal approach. Citric acid was used as a chelating and modifying agent for tuning the structure and porosity of the HAp structure. This is the first report to use citric acid as a modifier for producing mesoporous nano HAp and F-doped FHAp. The obtained samples were characterized by different analyses. The XRD data revealed that F is incorporated well into the HAp crystal structure. The crystallinity of HAp samples was improved and the unit cell volume was lowered with fluorine incorporation. Transmission electron microscopy (TEM) images of the obtained samples revealed that a nano rod-like shape was obtained. The mesoporous structures of the produced HAp samples were confirmed by Brunauer–Emmett–Teller (BET) analysis. In vivo studies performed using zebrafish and C. elegans prove the non-toxic behavior of the synthesized F doped HAp samples. The obtained samples are also analyzed for antimicrobial activity using Gram-negative and Gram-positive bacteria, which are majorly involved in implant failure. The F doped samples revealed excellent bactericidal activity. Hence, this study confirms that the non-toxic and excellent antibacterial mesoporous F doped HAp can be a useful candidate for biocidal implant application.

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Fabrication of copper ions-substituted hydroxyapatite/polydopamine nanocomposites with high antibacterial and angiogenesis effects for promoting infected wound healing

Cited by 35 publications

References 58 publications

Polydopamine, harness of the antibacterial potentials-A review

Polydopamine, harness of the antibacterial potentials-A review

Morphological Changes, Antibacterial Activity, and Cytotoxicity Characterization of Hydrothermally Synthesized Metal Ions-Incorporated Nanoapatites for Biomedical Application

Citric Acid-Mediated Microwave-Hydrothermal Synthesis of Mesoporous F-Doped HAp Nanorods from Bio-Waste for Biocidal Implant Applications

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