Fabrication of Collagen/HAP Electrospun Scaffolds with Perfect HAP Nanorods Along Nanofiber Orientation

Zhou, Yuanyuan; Song, Lixin; Wang, Da-Lu; Han, Xiaomin; Lei, X. L.

doi:10.1166/sam.2018.3278

Cited by 4 publications

(2 citation statements)

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“…Biopolymer/bioceramic composites have attracted increasing attention for their use as scaffold materials in bone tissue engineering because they might combine good processability of biopolymer with excellent bioactivity of bioceramic [ [1] , [2] , [3] ]. Among various biopolymer materials, poly- l -lactic acid (PLLA) is one of the promising materials because of its good biocompatibility and biodegradability [ [4] , [5] , [6] ].…”

Section: Introductionmentioning

confidence: 99%

Accelerated degradation of HAP/PLLA bone scaffold by PGA blending facilitates bioactivity and osteoconductivity

Shuai

Yang

Feng

et al. 2021

Bioactive Materials

266

124

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The incorporation of hydroxyapatite (HAP) into poly- l -lactic acid (PLLA) matrix serving as bone scaffold is expected to exhibit bioactivity and osteoconductivity to those of the living bone. While too low degradation rate of HAP/PLLA scaffold hinders the activity because the embedded HAP in the PLLA matrix is difficult to contact and exchange ions with body fluid. In this study, biodegradable polymer poly (glycolic acid) (PGA) was blended into the HAP/PLLA scaffold fabricated by laser 3D printing to accelerate the degradation. The results indicated that the incorporation of PGA enhanced the degradation rate of scaffold as indicated by the weight loss increasing from 3.3% to 25.0% after immersion for 28 days, owing to the degradation of high hydrophilic PGA and the subsequent accelerated hydrolysis of PLLA chains. Moreover, a lot of pores produced by the degradation of the scaffold promoted the exposure of HAP from the matrix, which not only activated the deposition of bone like apatite on scaffold but also accelerated apatite growth. Cytocompatibility tests exhibited a good osteoblast adhesion, spreading and proliferation, suggesting the scaffold provided a suitable environment for cell cultivation. Furthermore, the scaffold displayed excellent bone defect repair capacity with the formation of abundant new bone tissue and blood vessel tissue, and both ends of defect region were bridged after 8 weeks of implantation.

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Section: Introductionmentioning

confidence: 99%

Accelerated degradation of HAP/PLLA bone scaffold by PGA blending facilitates bioactivity and osteoconductivity

Shuai

Yang

Feng

et al. 2021

Bioactive Materials

266

124

View full text Add to dashboard Cite

show abstract

“…Researchers recently produced an electrospun poly(ε-caprolactone)/HAP composite mat with excellent physical and chemical properties that could be used as a promising substitute for bone regeneration [13,14]. Besides, poly(lactic acid– co –glycolic acid) [15], polyvinyl alcohol [16], and some natural materials [17,18] have been studied as well. All of these polymers and their composite blend not only mimic the natural tissues structure but are also compatible for HAP nucleation and growth.…”

Section: Introductionmentioning

confidence: 99%

Biomimetic Growth of Hydroxyapatite on Electrospun CA/PVP Core–Shell Nanofiber Membranes

et al. 2018

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In this study, cellulose acetate (CA)/polyvinylpyrrolidone (PVP) core–shell nanofibers were successfully fabricated by electrospinning their homogeneous blending solution. Uniform and cylindrical nanofibers were obtained when the PVP content increased from 0 to 2 wt %. Because of the concentration gradient associated with the solvent volatilization, the composite fibers flattened when the PVP increased to 5 wt %. Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD) results confirmed the existence of a hydrogen bond between the CA and PVP molecules, which enhanced the thermodynamic properties of the CA/PVP nanofibers, as shown by differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA) results. To analyze the interior structure of the CA/PVP fibers, the water-soluble PVP was selectively removed by immersing the fiber membranes in deionized water. Scanning electron microscopy (SEM) and transmission electron microscopy (TEM) indicated that the PVP component, which has a low surface tension, was driven to the exterior of the fiber to form a discontinuous phase, whereas the high-content CA component inclined to form the internal continuous phase, thereby generating a core–shell structure. After the water-treatment, the CA/PVP composite fibers provided more favorable conditions for mineral crystal deposition and growth. Energy-dispersive spectroscopy (EDS) and FTIR proved that the crystal was hydroxyapatite (HAP) and that the calcium to phosphorus ratio was 1.47, which was close to the theoretical value of 1.67 in HAP. Such nanofiber membranes could be potentially applicable in bone tissue engineering.

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Characterizations and interfacial reinforcement mechanisms of multicomponent biopolymer based scaffold

Feng

Peng

et al. 2019

Materials Science and Engineering: C

100

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Fabrication of Collagen/HAP Electrospun Scaffolds with Perfect HAP Nanorods Along Nanofiber Orientation

Cited by 4 publications

References 0 publications

Accelerated degradation of HAP/PLLA bone scaffold by PGA blending facilitates bioactivity and osteoconductivity

Accelerated degradation of HAP/PLLA bone scaffold by PGA blending facilitates bioactivity and osteoconductivity

Biomimetic Growth of Hydroxyapatite on Electrospun CA/PVP Core–Shell Nanofiber Membranes

Characterizations and interfacial reinforcement mechanisms of multicomponent biopolymer based scaffold

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