Fabrication of cationic nanostructures from short self-assembling amphiphilic mixed α/β-pentapeptide: Potential candidates for drug delivery, gene delivery, and antimicrobial applications

Goel, Rahul; Garg, Chanchal; Gautam, Hemant K.; Sharma, Ashwani; Kumar, Pradeep; Gupta, Atul

doi:10.1016/j.ijbiomac.2018.01.079

Cited by 17 publications

(17 citation statements)

References 78 publications

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“…Similarly, the Gupta group included unnatural β-alanine residues, alongside the use of a natural l -α form of lysine, to improve proteolytic stability. 78 The pentapeptide Lys-βAla-βAla-Lys-βAla demonstrated broad spectrum antibacterial efficacy due to its amphiphilic nature, alongside an ability to self-assemble into nanovesicles. However, hydrogel formation was not observed.…”

Section: Linking Self-assembly Mechanical and Antimicrobial Properties Of Peptide Hydrogelsmentioning

confidence: 99%

Unravelling the antimicrobial activity of peptide hydrogel systems: current and future perspectives

et al. 2021

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Section: Linking Self-assembly Mechanical and Antimicrobial Properties Of Peptide Hydrogelsmentioning

confidence: 99%

Unravelling the antimicrobial activity of peptide hydrogel systems: current and future perspectives

et al. 2021

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“…Natural and engineered antimicrobial peptides (AMPs) are generally short cationic peptides (10-50 amino acids). AMPs have attracted great interest in the treatment of bacterial infections, and their amphipathic nature also opens up the possibility of developing supramolecular nanostructures, such as fibers (Liu et al, 2013), nanoparticles (Goel et al, 2018), nanoribbons, or hydrogels (Veiga et al, 2012;Jiang et al, 2015;Baral et al, 2016;Nandi et al, 2017;Ye et al, 2019). For example, the AMPs GL13K and 1018 are able to selfassemble into stable secondary β-sheet structures (Haney et al, 2017;Ye et al, 2019), which can enable the organization of intrinsically disordered protein polymers (IDPPs) into hierarchical architectures.…”

Section: Amp-elrsmentioning

confidence: 99%

Fibrous Scaffolds From Elastin-Based Materials

Rodríguez‐Cabello

Torre

González-Pérez

et al. 2021

Front. Bioeng. Biotechnol.

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Current cutting-edge strategies in biomaterials science are focused on mimicking the design of natural systems which, over millions of years, have evolved to exhibit extraordinary properties. Based on this premise, one of the most challenging tasks is to imitate the natural extracellular matrix (ECM), due to its ubiquitous character and its crucial role in tissue integrity. The anisotropic fibrillar architecture of the ECM has been reported to have a significant influence on cell behaviour and function. A new paradigm that pivots around the idea of incorporating biomechanical and biomolecular cues into the design of biomaterials and systems for biomedical applications has emerged in recent years. Indeed, current trends in materials science address the development of innovative biomaterials that include the dynamics, biochemistry and structural features of the native ECM. In this context, one of the most actively studied biomaterials for tissue engineering and regenerative medicine applications are nanofiber-based scaffolds. Herein we provide a broad overview of the current status, challenges, manufacturing methods and applications of nanofibers based on elastin-based materials. Starting from an introduction to elastin as an inspiring fibrous protein, as well as to the natural and synthetic elastin-based biomaterials employed to meet the challenge of developing ECM-mimicking nanofibrous-based scaffolds, this review will follow with a description of the leading strategies currently employed in nanofibrous systems production, which in the case of elastin-based materials are mainly focused on supramolecular self-assembly mechanisms and the use of advanced manufacturing technologies. Thus, we will explore the tendency of elastin-based materials to form intrinsic fibers, and the self-assembly mechanisms involved. We will describe the function and self-assembly mechanisms of silk-like motifs, antimicrobial peptides and leucine zippers when incorporated into the backbone of the elastin-based biomaterial. Advanced polymer-processing technologies, such as electrospinning and additive manufacturing, as well as their specific features, will be presented and reviewed for the specific case of elastin-based nanofiber manufacture. Finally, we will present our perspectives and outlook on the current challenges facing the development of nanofibrous ECM-mimicking scaffolds based on elastin and elastin-like biomaterials, as well as future trends in nanofabrication and applications.

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“…Goel et al reported on a short self-assembling amphiphilic mixed α/β pentapeptide; in comparison to peptides containing only α amino acids, mixed peptide present greater chemical and physical diversity, excellent stability and activity. In particular, this pentapeptide (H-Lys-βAla-βAla-Lys-βAla-OEt) was active against both Gram-positive and Gram-negative bacterial strains [100].…”

Section: Reports On Self-assembling Systems With Antimicrobial Promentioning

confidence: 99%

A New Hope: Self-Assembling Peptides with Antimicrobial Activity

et al. 2019

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Peptide drugs hold great promise for the treatment of infectious diseases thanks to their novel mechanisms of action, low toxicity, high specificity, and ease of synthesis and modification. Naturally developing self-assembly in nature has inspired remarkable interest in self-assembly of peptides to functional nanomaterials. As a matter of fact, their structural, mechanical, and functional advantages, plus their high bio-compatibility and bio-degradability make them excellent candidates for facilitating biomedical applications. This review focuses on the self-assembly of peptides for the fabrication of antibacterial nanomaterials holding great interest for substituting antibiotics, with emphasis on strategies to achieve nano-architectures of self-assembly. The antibacterial activities achieved by these nanomaterials are also described.

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Fabrication of cationic nanostructures from short self-assembling amphiphilic mixed α/β-pentapeptide: Potential candidates for drug delivery, gene delivery, and antimicrobial applications

Cited by 17 publications

References 78 publications

Unravelling the antimicrobial activity of peptide hydrogel systems: current and future perspectives

Unravelling the antimicrobial activity of peptide hydrogel systems: current and future perspectives

Fibrous Scaffolds From Elastin-Based Materials

A New Hope: Self-Assembling Peptides with Antimicrobial Activity

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