Fabrication of cationic nanomicelle from chitosan-graft-polycaprolactone as the carrier of 7-ethyl-10-hydroxy-camptothecin

Duan, Kongrong; Zhang, Xiaolan; Tang, Xiangming; Yu, Jiahui; Liu, Shiyuan; Wang, Daxin; Li, Yaping; Huang, Jin

doi:10.1016/j.colsurfb.2009.12.007

Cited by 85 publications

(64 citation statements)

References 37 publications

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“…-Potential has been used previously by several authors for biopolymers, emulsions, etc. [7,10,[38][39][40][41]. The surface charge of a biopolymer arises primarily from the ionization of its surface polar groups.…”

Section: Characterizationmentioning

confidence: 99%

Interactions between whey protein isolate and gum Arabic

Klein

Aserin

Ishai

et al. 2010

Colloids and Surfaces B: Biointerfaces

110

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Section: Characterizationmentioning

confidence: 99%

Interactions between whey protein isolate and gum Arabic

Klein

Aserin

Ishai

et al. 2010

Colloids and Surfaces B: Biointerfaces

110

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“…23 The various concentrations of ε-caprolactone grafted onto chitosan from a molar ratio of 8/1 to 24/1 increased the hydrodynamic diameters from 47 to 113 nm. 24 The micellar particle size increased with an increase in the PCL segments; however, all values are smaller than that of CSMA-g-PCL.…”

Section: Micellar Properties and Drug Encapsulationmentioning

confidence: 87%

Self-assembled poly(ε-caprolactone)-g-chondroitin sulfate copolymers as an intracellular doxorubicin delivery carrier against lung cancer cells

Lin¹,

Liu²,

Yeh³

et al. 2012

IJN

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The aim of this study was to utilize self-assembled polycaprolactone (PCL)-grafted chondroitin sulfate (CS) as an anticancer drug carrier. We separately introduced double bonds to the hydrophobic PCL and the hydrophilic CS. The modified PCL was reacted with the modified CS through a radical reaction (CSMA-g-PCL). The copolymer without doxorubicin (DOX) was noncytotoxic in CRL-5802 and NCI-H358 cells at a concentration ranging from 5–1000 μg/mL and DOX-loaded CSMA-g-PCL (Micelle DOX) had the lowest inhibitory concentration of 50% cell growth values against the NCI-H358 cells among test samples. The cellular uptake of Micelle DOX into the cells was confirmed by flow cytometric data and confocal laser scanning microscopic images. The in vivo tumor-targeting efficacy of Micelle DOX was realized using an NCI-H358 xenograft nude mouse model. The mice administered with Micelle DOX showed suppressed growth of the NCI-H358 lung tumor compared with those administered with phosphate-buffered saline and free DOX.

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“…For instance, star-shaped or multi-armed micelles can be formed with an amphiphilic block copolymer with multiple hydrophilic blocks and a single hydrophobic block 27 . These polymers can form micelles if the number of arms is high enough.…”

Section: Multi-arm Block Copolymersmentioning

confidence: 99%

Untitled

2018

IJPSR

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ABSTRACT:In this article, we have reviewed several features of nanomicelles relating to their general properties, preparation and characterization techniques, and their applications in the areas of ocular drug delivery system. Nanomicelles can be rummage-sale as 'smart drug carriers' for targeting certain areas of the eye by making them stimuli-sensitive or by attachment of a specific ligand molecule onto their surface. In present scenario, the major challenge for the researchers is ocular drug delivery system as eye is the most sensitive organ in our body. Topical eye drop is the best suited way for delivery of drugs for the treatment of anterior segment of the eye. Delivery of the drugs to the targeted areas is restricted by the various barriers and even the amount instilled do not remain there for a long duration of time. In the past many years scientist are working on providing the masses the way for delivering drug in a novel, safe and patience compliance manner. The aided the basic delivery by providing the administration through various permeation enhancers and viscosity modifiers. Widely studied subjects in nanoscience technology is related to the conception of supramolecular architectures with well-defined structures and functionalities. Nanomicelles have congregated considerable attention in the field of drug and ocular drug delivery due to their exceptional biocompatibility, low toxicity, enhanced blood circulation time.

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Fabrication of cationic nanomicelle from chitosan-graft-polycaprolactone as the carrier of 7-ethyl-10-hydroxy-camptothecin

Cited by 85 publications

References 37 publications

Interactions between whey protein isolate and gum Arabic

Interactions between whey protein isolate and gum Arabic

Self-assembled poly(ε-caprolactone)-g-chondroitin sulfate copolymers as an intracellular doxorubicin delivery carrier against lung cancer cells

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Fabrication of cationic nanomicelle from chitosan-graft-polycaprolactone as the carrier of 7-ethyl-10-hydroxy-camptothecin

Cited by 85 publications

References 37 publications

Interactions between whey protein isolate and gum Arabic

Interactions between whey protein isolate and gum Arabic

Self-assembled poly(&epsilon;-caprolactone)-g-chondroitin sulfate copolymers as an intracellular doxorubicin delivery carrier against lung cancer cells

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Self-assembled poly(ε-caprolactone)-g-chondroitin sulfate copolymers as an intracellular doxorubicin delivery carrier against lung cancer cells