Fabrication of bone cement that fully transforms to carbonate apatite

Cahyanto, Arief; Maruta, Michito; Tsuru, Kanji; Matsuya, Shigeki; Ishikawa, Kunio

doi:10.4012/dmj.2014-328

Cited by 41 publications

(44 citation statements)

References 29 publications

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“…In a dissolution-precipitation reaction, precipitation cannot occur without prior dissolution of the starting materials. The dissolution of starting materials is accelerated in acidic conditions, as mentioned by Cahyanto et al [21]. In other words, the dissolution of materials was slower in an alkaline solution.…”

Section: Resultsmentioning

confidence: 87%

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Preparation of carbonate apatite scaffolds using different carbonate solution and soaking time

Darus

Jaafar

Ahmad

2019

PAC

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The aim of this study is to fabricate CO 3 Ap scaffolds using a dissolution-precipitation reaction during hydrothermal treatment. Beta-tricalcium phosphate (β-TCP) was used as a precursor instead of the commonly used alpha-tricalcium phosphate (α-TCP). Here, the CO 3 Ap scaffold fabrication was accomplished in two steps: i) fabrication of β-TCP scaffold using a combination of direct foaming and a sacrificial template and ii) hydrothermal conversion of the β-TCP scaffold at 200°C in 2 mol/l NaHCO 3 and Na 2 CO 3 aqueous solutions for 2-10 days. The effect of two different solutions was identified in the dissolution-precipitation reaction. CO 3 Ap scaffold with 8.95 wt.% carbonate content was successfully fabricated using a NaHCO 3 solution. The average pore size of the scaffold was approximately 180 µm with 72% porosity. The average compressive strength of the CO 3 Ap scaffold was 0.7 MPa. Based on the compressive strength and carbonate content results, NaHCO 3 aqueous solutions were chosen as carbonate sources for phase transformation to fabricate a CO 3 Ap scaffold over 6 days.

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Section: Resultsmentioning

confidence: 87%

“…2k. Cahyanto et al [21] reported that the crystals will interlock to set and harden. Although slightly different mechanical properties were reported, there were no differences in term of scaffolds' porosity treated in either NaHCO 3 or Na 2 CO 3 aqueous solution.…”

Section: Resultsmentioning

confidence: 99%

Preparation of carbonate apatite scaffolds using different carbonate solution and soaking time

Darus

Jaafar

Ahmad

2019

PAC

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“…For a core material, calcium carbonate (CaCO 3 ) was used to decrease the material resorption rate and promote the osteogenic potential due to Ca 2+ release. CO 3 Ap blocks are fabricated through a dissolution‐precipitation reaction using a precursor such as CaCO 3 , tricalcium phosphate, gypsum, and calcium phosphate dihydrate (Ayukawa, Suzuki, Tsuru, Koyano, & Ishikawa, ; Cahyanto, Maruta, Tsuru, Matsuya, & Ishikawa, ; Kunio Ishikawa, ; Kunio Ishikawa et al, ; Kanazawa et al, ; Lin, Matsuya, Nakagawa, Terada, & Ishikawa, ; Wakae et al, ). For example, CO 3 Ap blocks are fabricated by immersing a CaCO 3 block in the Na 2 HPO 4 solution.…”

Section: Introductionmentioning

confidence: 99%

Fabrication and evaluation of carbonate apatite-coated calcium carbonate bone substitutes for bone tissue engineering

Fujioka‐Kobayashi

Tsuru

Nagai

et al. 2018

J Tissue Eng Regen Med

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Carbonate apatite-coated calcium carbonate (CO Ap/CaCO ) was fabricated through a dissolution-precipitation reaction using CaCO granules as a precursor to accelerate bone replacement based on superior osteoconductivity of the CO Ap shell, along with Ca release from the CaCO core and quicker resorption of the CaCO core. In the present study, CaCO , 10% CO Ap/CaCO , 30% CO Ap/CaCO , and CO Ap granules were fabricated and examined histologically to evaluate their potential as bone substitutes. Larger contents of CaCO in the granules resulted in higher Ca release and promoted cell proliferation of murine preosteoblasts at 6 days compared with CO Ap. Interestingly, in a rabbit femur defect model, 10% CO Ap/CaCO induced significantly higher new bone formation and higher material resorption compared with CO Ap at 8 weeks. Nevertheless, CO Ap showed a superior osteoconductive potential compared with 10% CO Ap/CaCO at 8 weeks. All tested granules were most likely resorbed by cell mediation including multinucleated giant cell functions. Therefore, we conclude that CO Ap/CaCO has a positive potential for bone tissue engineering based on well-controlled calcium release, bone formation, and material resorption.

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“…2 Bone cement formulations consist of vaterite (a polymorph of CaCO 3 ) and dicalcium phosphate anhydrous (DCPA) as powder phase mixed with sodium phosphate solution can fully transform to CO 3 Ap in physiological conditions. 3,4,5 Based on the previous study, this CO 3 Ap cement with L/P ratio of 0.45 will set in 11 minutes. 3,4,5 The powder formulation is 40 wt% of vaterite and 60 wt% of DCPA were required for the full formation of CO 3 Ap.…”

Section: Introductionmentioning

confidence: 99%

“…3,4,5 Based on the previous study, this CO 3 Ap cement with L/P ratio of 0.45 will set in 11 minutes. 3,4,5 The powder formulation is 40 wt% of vaterite and 60 wt% of DCPA were required for the full formation of CO 3 Ap. 3,4,5 Apatite cement can be used to repair bone defects such as alveolar bone defect and dental implant fixation.…”

Section: Introductionmentioning

confidence: 99%

Setting time evaluation of injectable carbonate apatite cement using various sodium carboxymethylcellulose (Na CMC) concentration

2018

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Introduction: The injectable calcium phosphate cement has the advantage to be used in the bone defect with the limited access which supports a minimally invasive surgical technique. These Injectability properties of calcium phosphate cement can be modified by adding a sodium carboxymethylcellulose (Na CMC). The aim of this present study is to investigate the setting time of injectable bone cement based on CO3Ap using various Na CMC concentration. Methods: Vaterite (a polymorph of CaCO3) and Dicalcium Phosphate Anhydrous (DCPA) as powder phase mixed with 0.2 mol/L Na2HPO4 solution containing 1% polyethylene glycol (PEG) and various concentration of Na CMC as followed 0.5%, 1%, 1.5%, and 2%, respectively. Each concentration groups was consisting of 5 samples from total 20 samples. Powder and liquid phase was mixed with a spatula at a liquid to powder (L/P) ratio of 0.4. The setting time of CO3Ap cement was evaluated according to the modification method standardized by ISO 1566 for dental zinc phosphate cement using a custom fabricated Vicat needle apparatus. The cement was maintained at 37ºC and 100% relative humidity as a standard requirement. Results: The mean value of setting time cement was as followed 0.5% Na CMC 35:06 minutes, 1% Na CMC 38:48 minutes, 1.5% Na CMC 40:06 minutes, and 2% Na CMC 41:30 minutes. The result is statistically significant (p<0.05) with the group of 0.5% Na CMC compared to others group. Conclusion: Increasing the concentration of Na CMC could prolong the setting time of CO3Ap cement.

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Fabrication of bone cement that fully transforms to carbonate apatite

Cited by 41 publications

References 29 publications

Preparation of carbonate apatite scaffolds using different carbonate solution and soaking time

Preparation of carbonate apatite scaffolds using different carbonate solution and soaking time

Fabrication and evaluation of carbonate apatite-coated calcium carbonate bone substitutes for bone tissue engineering

Setting time evaluation of injectable carbonate apatite cement using various sodium carboxymethylcellulose (Na CMC) concentration

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