Fabrication of Bacterial Cellulose-Curcumin Nanocomposite as a Novel Dressing for Partial Thickness Skin Burn

Abstract

The current study aimed to fabricate curcumin-loaded bacterial cellulose (BC-Cur) nanocomposite as a potential wound dressing for partial thickness burns by utilizing the therapeutic features of curcumin and unique structural, physico-chemical, and biological features of bacterial cellulose (BC). Characterization analyses confirmed the successful impregnation of curcumin into the BC matrix. Biocompatibility studies showed the better attachment and proliferation of fibroblast cells on the BC-Cur nanocomposite. The antibacterial potential of curcumin was tested against Escherichia coli (E. coli), Pseudomonas aeruginosa (P. aeruginosa), Salmonella typhimurium (S. typhimurium), and Staphylococcus aureus (S. aureus). Wound healing analysis of partial-thickness burns in Balb c mice showed an accelerated wound closure up to 64.25% after 15 days in the BC-Cur nanocomposite treated group. Histological studies showed healthy granulation tissues, fine re-epithelialization, vascularization, and resurfacing of wound bed in the BC-Cur nanocomposite group. These results indicate that combining BC with curcumin significantly improved the healing pattern. Thus, it can be concluded that the fabricated biomaterial could provide a base for the development of promising alternatives for the conventional dressing system in treating burns.

Self-Healing Hydrogels: Preparation, Mechanism and Advancement in Biomedical Applications

“…4.1.5. Bacterial Cellulose Based Self-Healing Hydrogel for Wound Healing Bacterial cellulose is an excellent hydrogel system used for wound healing, drug delivery, and tissue engineering applications [107][108][109]. Khamrai et al developed a bioderived self-healing wound healing patch made of curcumin loaded onto gelatin and ionically modified bacterial cellulose composite.…”

Perspective Applications and Associated Challenges of Using Nanocellulose in Treating Bone-Related Diseases

“…Nanocellulose, mainly BNC, is applied in different forms to humans, such as skin substitute (Khan et al, 2018), wound dressing materials (Sajjad et al, 2020), synthetic blood vessels (Scherner et al, 2014), artificial cornea (Wang et al, 2010), bone and cartilage (Basu et al, 2018), synthetic heart valves (Mohammadi, 2011), gastrointestinal tract (Lamboni et al, 2019), tympanic membrane (Kim et al, 2013), dental implants (Jinga et al, 2014), neural implants (Yang et al, 2017), urinary conduit replacement (Huang et al, 2015), contact lenses (Cavicchioli et al, 2015), and several others, and therefore, it is necessary to identify the associated potential health risks (Endes et al, 2016). Several studies have reported brown lung, alveo-bronchiolitis, fibrosis, and granulomatous inflammation in vivo following the exposure to cellulose (Tátrai et al, 1995).…”

Ex situ Synthesis and Characterization of High Strength Multipurpose Bacterial Cellulose-Aloe vera Hydrogels

“…For example, the presence of plentiful hydroxyl groups on its surface imparts hydrophilic nature to BC. Both the water holding and retention potential of BC are important from a medical perspective, especially in drug delivery ( Li et al, 2018 ) and wound dressing ( Di et al, 2017 ; Ciecholewska-Jusìko et al, 2020 ; Sajjad et al, 2020 ), where such properties are associated with the absorption of wound exudates and holding the drug for an extended time, thus greatly contributing to enhancing the therapeutic potential of BC. The free hydroxyl groups on the cellulose surface give rise to a binding module where the adsorption of the drug is driven through the formation of hydrogen bonding and van der Waals forces or through the electrostatic/aromatic interactions ( Lombardo and Thielemans, 2019 ).…”