Fabrication of an ionic liquid-based macroporous polymer monolithic column via atom transfer radical polymerization for the separation of small molecules

Zhang, Hang; Bai, Ligai; Wei, Zhen; Liu, Sha; Liu, Haiyan; Yan, Hongyuan

doi:10.1016/j.talanta.2015.11.028

Cited by 34 publications

(19 citation statements)

References 33 publications

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“…The characteristic peaks corresponding to C=N (1545 cm −1 ) and C=C (1456 cm −1 ) from the imidazole ring were observed . These significant groups revealed that IL (containing imidazole ring) was present in the IL‐TMIP . From the thermogravimetric analysis results (Figure B), the weight retention of IL 1 ‐TMIP, IL 2 ‐TMIP, and IL 3 ‐TMIP at 500°C was less than 20% and there was obvious weight loss before 100°C.…”

Section: Resultsmentioning

confidence: 92%

“…To obtain the suitable permeability and backpressure monolithic column, the molar ratio (5.00:0.420, 4.00:0.420, 3.00:0.420, and 1.00:0.420) between the thermoresponsive monomer (NIPAAm) and dummy template (9,10‐phenanthrenequinone), the volume ratio of tri‐porogens (ACN/PEG400/DMSO), and the dose of auxiliary modification monomer (IL) were investigated. The permeability was calculated using Darcy's Law .

B_{0} = F η L / (π r^{2} Δ P),

where B 0 is the permeability of monolithic column, F is the flow rate of the mobile phase (m 3 /s), η is the dynamic viscosity of the mobile phase (Pa s), L is the effective column length (m), r is the inner radius of the column (m), and Δ P is the pressure drop across the column, which was measured from 0.10 to 1.0 mL/min at 30°C.…”

Section: Resultsmentioning

confidence: 99%

“…To obtain the suitable permeability and backpressure monolithic column, the molar ratio (5.00:0.420, 4.00:0.420, 3.00:0.420, and 1.00:0.420) between the thermoresponsive monomer (NIPAAm) and dummy template (9,10phenanthrenequinone), the volume ratio of tri-porogens (ACN/PEG400/DMSO), and the dose of auxiliary modification monomer (IL) were investigated. The permeability was calculated using Darcy's Law [19].…”

Section: Optimization For Il-tnip Monolithic Columnmentioning

confidence: 99%

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Hydrophobic ionic liquid modified thermoresponsive molecularly imprinted monolith for the selective recognition and separation of tanshinones

Tang

Row

2018

J of Separation Science

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A hydrophobic ionic liquid modified thermoresponsive molecularly imprinted monolith was synthesized using N-isopropylacrylamide as a thermoresponsive monomer and a long-chain hydrophobic ionic liquid as an auxiliary modification monomer. The ionic-liquid-modified thermoresponsive molecularly imprinted polymer was characterized by scanning electron microscopy and Fourier transform infrared spectroscopy. When the column temperature was 50°C, the synthesized monolithic column was successfully applied to the selective separation of homologue tanshinones within 7 min and eluted only by water (mobile phase) (theoretical plates more than 1.00 × 10 per meter). The negative Gibbs free energy (≤-2.37) values showed that the transfer of the tanshinones from the mobile phase to the stationary phase on this monolithic column was a thermodynamically spontaneous process. Good linearity of the five tanshinones by thermoresponsive monolith was obtained in the range of 0.100-25.0 μg/mL. The limit of detection (S/N = 3) and limit of quantitation (S/N = 10) were less than 0.0390 and 0.0630 μg/mL, respectively, with a relative standard deviation of <4.8%. In this proposed thermoresponsive chromatography method, the separation of homologue analytes can be achieved by changing the column temperature, and the use of water as the mobile phase would decrease the economic cost and organic pollution.

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Section: Resultsmentioning

confidence: 92%

B_{0} = F η L / (π r^{2} Δ P),

Section: Resultsmentioning

confidence: 99%

“…To obtain the suitable permeability and backpressure monolithic column, the molar ratio (5.00:0.420, 4.00:0.420, 3.00:0.420, and 1.00:0.420) between the thermoresponsive monomer (NIPAAm) and dummy template (9,10phenanthrenequinone), the volume ratio of tri-porogens (ACN/PEG400/DMSO), and the dose of auxiliary modification monomer (IL) were investigated. The permeability was calculated using Darcy's Law [19].…”

Section: Optimization For Il-tnip Monolithic Columnmentioning

confidence: 99%

See 1 more Smart Citation

Hydrophobic ionic liquid modified thermoresponsive molecularly imprinted monolith for the selective recognition and separation of tanshinones

Tang

Row

2018

J of Separation Science

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“…Meanwhile, the organic polymer monolithic column with anion‐exchange interaction exhibits good performance and gets more and more attention. Acrylamides and ionic liquids are often used as functional monomers to form anion‐exchange stationary phases. With the development of this kind of monolithic columns, the monomers are increasingly scarce.…”

Section: Introductionmentioning

confidence: 99%

Monolithic column functionalized with quinine derivative for anion‐exchange capillary electrochromatography

2018

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A novel anion-exchange organic polymer monolithic column based on monomers N-benzylquininium chloride and acrylamide were firstly prepared by in situ copolymerization for capillary electrochromatography. Moreover, N-benzylquininium was firstly introduced as a strong anion-exchange functional group. A relatively strong anodic EOF was obtained in the pH values from 4.0 to 9.0, which was in the same direction with the electrophoretic mobility of acid compounds. Hence, the anion-exchange monolithic column was very suitable for the rapid separation of acid compounds. Eight acid compounds (2-chlorobenzoic acid, mandelic acid, 4-hydroxybenzoic acid, indole-3-acetic acid, 2-aminoterephthalic acid, 3,5-pyridinedicarboxylic acid, benzoic acid, and 4-aminobenzoic acid) were successfully separated on the monolithic column. The highest column efficiency was 4.60 × 10 plates/m (theoretical plates, N) for 3,5-pyridinedicarboxylic acid. The proposed monolithic column was characterized by SEM and FT-IR. The RSDs of the acid compounds migration time for run-to-run, day-to-day, and column-to-column were all less than 5.0%.

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“…The separation of small molecules has been the focus in recent years . However, monolithic columns suffer from the disadvantages that it is difficult for them to separate small molecules and biological macromolecules at the same time because of the large pores sizes in the monolithic structure and the inhomogeneity of the structure . Although capillary liquid chromatography has often been used in the separation of small molecules and macromolecules, capillary monolithic columns also have many disadvantages, such as poor reproducibility and complex preparation procedure.…”

Section: Introductionmentioning

confidence: 99%

Preparation and application of a multiwalled carbon nanotube composite monolithic column

Wang

Jiang

et al. 2017

J of Applied Polymer Sci

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A multiwalled carbon nanotube (MWCNT) composite monolithic column was prepared by the redox initiation method, and MWCNTs were embedded into the monolithic material. In this experiment, 1-octene was used as monomer, triethylene glycol dimethacrylate was used as the crosslinking agent, propanol and 1-dodecanol were used as porogens, hydroxyl-functionalized MWCNTs were used as the inorganic material, and dibenzoyl peroxide and N,N-dimethyl aniline were used as initiators. The MWCNT composite monolithic column was characterized by scanning electron microscopy, mercury intrusion porosimetry, and nitrogen adsorption-desorption isotherm measurements. The MWCNT composite monolith showed a uniform structure and a high permeability. The MWCNT composite monolithic column uses the high-performance liquid chromatography to analyze the sample. Compared with the monolithic column without MWCNTs, the MWCNT composite monolith not only improved the column efficiency but also shortened the separation time. Six small molecules were successfully separated by the MWCNT composite monolith in 3 min, with the highest column efficiency reaching 36,000 plates/m In addition, the monolith was also used to separate complex protein samples, including snailase, plasma, and egg white. Therefore, the monolithic column was suitable both for the separation of macromolecules and small molecules.

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Fabrication of an ionic liquid-based macroporous polymer monolithic column via atom transfer radical polymerization for the separation of small molecules

Cited by 34 publications

References 33 publications

Hydrophobic ionic liquid modified thermoresponsive molecularly imprinted monolith for the selective recognition and separation of tanshinones

Hydrophobic ionic liquid modified thermoresponsive molecularly imprinted monolith for the selective recognition and separation of tanshinones

Monolithic column functionalized with quinine derivative for anion‐exchange capillary electrochromatography

Preparation and application of a multiwalled carbon nanotube composite monolithic column

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