Fabrication of activated carbon fiber functionalized core–shell silver nanoparticles based in situ and low-cost technology for wound dressings with an enhanced antimicrobial activity and cell viability

Hafez, Eslam; Shaban, Samy M.; Kim, Min-Hyeong; Elbalaawy, Ahmed; Pyun, Do-Gi; Kim, Dong Hwan

doi:10.1016/j.molliq.2022.119561

Cited by 6 publications

(2 citation statements)

References 76 publications

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“…Orlowski and his group reported the development of tannic acid-modified AgNPs with antiviral activities against Herpes Simplex Virus Type 2 [ 39 , 40 ]. The simultaneous use of crosslinked chitosan and tannic acid to reduce and/or stabilize metals and metal oxides, including silver, was reported by several groups, and the final systems were used for various applications, including a catalytic system for electrochemical detection and in synthetic processes [ 41 , 42 ] and as a promising wound dressing material [ 43 ].…”

Section: Introductionmentioning

confidence: 99%

Highly Stable Core-Shell Nanocolloids: Synergy between Nano-Silver and Natural Polymers to Prevent Biofilm Formation

et al. 2022

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Active investment in research time in the development and study of novel unconventional antimicrobials is trending for several reasons. First, it is one of the ways which might help to fight antimicrobial resistance and bacterial contamination due to uncontrolled biofilm growth. Second, minimizing harmful environmental outcomes due to the overuse of toxic chemicals is one of the highest priorities nowadays. We propose the application of two common natural compounds, chitosan and tannic acid, for the creation of a highly crosslinked polymer blend with not only intrinsic antimicrobial properties but also reducing and stabilizing powers. Thus, the fast and green synthesis of fine spherically shaped Ag nanoparticles and further study of the composition and properties of the colloids took place. A positively charged core-shell nanocomposition, with an average size in terms of the metal core of 17 ± 4 nm, was developed. Nanoantimicrobials were characterized by several spectroscopic (UV-vis and FTIR) and microscopic (transmission and scanning electron microscopies) techniques. The use of AgNPs as a core and an organic polymer blend as a shell potentially enable a synergistic long-lasting antipathogen effect. The antibiofilm potential was studied against the food-borne pathogens Salmonella enterica and Listeria monocytogenes. The antibiofilm protocol efficiency was evaluated by performing crystal violet assay and optical density measurements, direct visualization by confocal laser scanning microscopy and morphological studies by SEM. It was found that the complex nanocomposite has the ability to prevent the growth of biofilm. Further investigation for the potential application of this stable composition in food packaging will be carried out.

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Section: Introductionmentioning

confidence: 99%

Highly Stable Core-Shell Nanocolloids: Synergy between Nano-Silver and Natural Polymers to Prevent Biofilm Formation

et al. 2022

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“…Moreover, data revealed that AgNPs@C showed CC50 reached 235.5 μg/mL. Hafez et al 60 found that despite the high antimicrobial activity of the prepared AgNPs@poly(tannic acid) (PTA) it showed high cytotoxicity towards L929 cells which hindered their biological applications and they needed to add natural cell viability enhancers (e.g. tannic acid and chitosan) to the prepared AgNPs@PTA (1000 ppm) in order to improve the cell viability.…”

Section: Resultsmentioning

confidence: 99%

Potent biological activity of newly fabricated silver nanoparticles coated by a carbon shell synthesized by electrical arc

Elwakil,

Eldrieny,

Almotairy

et al. 2024

Sci Rep

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Highly effective AgNPs@C was efficiently synthesized by electrical arc powered by single spark unit which was sufficient to ionize the dielectric media (deionized water) through applying strong electric field between the electrodes (silver and carbon). The AgNPs@C shell was characterized in terms of stability, morphology and phase structure. All characterizations showed that the prepared silver nanoparticles were spherical with average size reached 17 nm coated with carbon shell. The antibacterial effect of the synthesized nanoparticles was tested against Pseudomonas aeruginosa in comparison to Ceftazidime (commonly used antibiotic against P. aeruginosa infections). It was revealed that AgNPs@C shell has superior activity with inhibition zone diameter reached 15 mm and minimum inhibitory concentration reached 2 µg/mL. The observed activity was further confirmed by confocal microscope which showed an increased red region, representing the dead cells, correlated with the presence of AgNPs@C. Moreover, transmission electron microscope studies implied the possible AgNPs@C antibacterial mechanism of action was the nanoparticles adherence to the bacterial membrane causing cell lysis. The molecular studies against fimH (virulence adhesion gene), rmpA (mucoid factor encoding gene), and mrkA (biofilm forming gene) proved the inhibition of their genetic expression. The cytotoxic effect of the synthesized AgNPs@C showed CC50 reached 235.5 μg/mL against normal lung cells (L929 cell line).

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State-of-the-Art of Synthesized Exosomes and NPs-Based Biomimetic Nanoparticles for Wound Rehabilitation: A Review

Issaka

2023

Biomedical Materials & Devices

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Fabrication of activated carbon fiber functionalized core–shell silver nanoparticles based in situ and low-cost technology for wound dressings with an enhanced antimicrobial activity and cell viability

Cited by 6 publications

References 76 publications

Highly Stable Core-Shell Nanocolloids: Synergy between Nano-Silver and Natural Polymers to Prevent Biofilm Formation

Highly Stable Core-Shell Nanocolloids: Synergy between Nano-Silver and Natural Polymers to Prevent Biofilm Formation

Potent biological activity of newly fabricated silver nanoparticles coated by a carbon shell synthesized by electrical arc

State-of-the-Art of Synthesized Exosomes and NPs-Based Biomimetic Nanoparticles for Wound Rehabilitation: A Review

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