Fabrication of a novel hydroxyapatite/polyether ether ketone surface nanocomposite via friction stir processing for orthopedic and dental applications

Almasi, Davood; Lau, Woei Jye; Rasaee, Sajad; Sharifi, Roohollah; Mozaffari, Hamid Reza

doi:10.1007/s40204-020-00130-7

Cited by 20 publications

(19 citation statements)

References 41 publications

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“…Sulfonation treatment [ 45 , 73 , 74 , 75 ], plasma immersion ion implantation [ 39 , 76 ] and bioactive coatings [ 72 , 77 , 78 ] are commonly used in surface modification of PEEK implants. In addition, by blending with fine filler particles to synthesize PEEK composites [ 25 , 79 , 80 , 81 , 82 ], bioactive implants with good osseointegration could be produced.…”

Section: Peek Materials In Oral Implantologymentioning

confidence: 99%

Review on Development and Dental Applications of Polyetheretherketone-Based Biomaterials and Restorations

et al. 2021

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Polyetheretherketone (PEEK) is an important high-performance thermoplastic. Its excellent strength, stiffness, toughness, fatigue resistance, biocompatibility, chemical stability and radiolucency have made PEEK attractive in dental and orthopedic applications. However, PEEK has an inherently hydrophobic and chemically inert surface, which has restricted its widespread use in clinical applications, especially in bonding with dental resin composites. Cutting edge research on novel methods to improve PEEK applications in dentistry, including oral implant, prosthodontics and orthodontics, is reviewed in this article. In addition, this article also discusses innovative surface modifications of PEEK, which are a focus area of active investigations. Furthermore, this article also discusses the necessary future studies and clinical trials for the use of PEEK in the human oral environment to investigate its feasibility and long-term performance.

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Section: Peek Materials In Oral Implantologymentioning

confidence: 99%

Review on Development and Dental Applications of Polyetheretherketone-Based Biomaterials and Restorations

et al. 2021

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“…Previous papers have typically used nanosize HA particles to fabricate scaffolds for bone tissue engineering. [ 35–39 ] Furthermore, these prior studies mainly focused on scaffold fabrication and in vitro cell response. [ 40–41 ] In addition, researchers have utilized HA in low concentrations in the literature.…”

Section: Introductionmentioning

confidence: 99%

“…[ 40–41 ] In addition, researchers have utilized HA in low concentrations in the literature. [ 35–37 ] In this study, we have used micrometer‐size HA particles to reinforce hydrogel scaffolds to improve the physical and mechanical properties, bioactivity, and osteogenesis of the 3D constructs as well as investigate the cell response and tissue integration in vivo. Our work utilized HA concentrations up to 20 mg mL −1 to generate osteoinductive scaffolds for engineering bone.…”

Section: Introductionmentioning

confidence: 99%

“…[ 37–39 ] In our study, commercially available nonprocessed HA microparticles were used at different concentrations within a gelatin‐based hydrogel (GelMA) matrix to increase the mechanical stability of the resulting scaffolds and promote osteogenic differentiation of the preosteoblasts. [ 32–35 ] Our approach is a unique way to achieve highly tunable osteoinductive scaffolds and enables to control the osteogenic differentiation of predifferentiated stem cells.…”

Section: Introductionmentioning

confidence: 99%

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Hydroxyapatite‐Incorporated Composite Gels Improve Mechanical Properties and Bioactivity of Bone Scaffolds

Suvarnapathaki

Lantigua

et al. 2020

Macromolecular Bioscience

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require mechanically strong scaffolds to support cell differentiation and mineral deposition. [8-10] The commonly used biomaterials, such as ceramics and metals, are mechanically robust but are compatible with only certain cell cultures. Despite relatively weak mechanical properties, hydrogels exhibit exceptional biomimetic properties and material tunability. [11,12] The spatial and temporal control found in hydrogel synthesis approaches also assists in generating modular mechanical and chemical properties. These aspects enable the generation of scaffolds that mimic the native tissue microenvironment. [13,14] Across all human tissue types, cells are sensitive and responsive to mechanical stresses and stiffnesses, including compression, tension, and shear. [15] Typically, the stiffness of hydrogels can be modified by adjusting the prepolymer concentration and the cross-linking time. [16,17] These techniques can result in stiffer hydrogels but lead to limitations in the biological performance of the material. These limitations have necessitated innovative approaches such as reinforcing hydrogels with nano/microfibers in various weaving patterns. [18,19] Another approach to improve the mechanical and biological properties of hydrogels simultaneously is to process these composite materials at higher cross-linking densities. The mechanical properties have been demonstrated to affect cell migration and tissue morphogenesis within the material. [8] More recently, hydroxyapatite ((HA), Ca 10 (PO 4) 6 (OH) 2), silver, and gold nanoparticles have been incorporated into hydrogels to enhance the scaffold's mechanical capabilities and cytocompatibility. [20,21] In previous works, HA has been used as a filling material to fabricate biocompatible matrices in orthopedic and mineralized implants. [22-24] HA has a natural tendency to bind to osseous tissues and its physical properties are similar to that of the native minerals in the human body. [22,25-29] The success of HApolymer composite materials has offered advanced and desirable qualities in biomimetic and mechanically competent bone tissue engineering scaffolds. [30] In the past, different forms of tissue scaffolds were fabricated using HA, such as electrospun fibers, 3D printed thermoplastic polymers, and freeze-dried matrices. [31-34] In our work, we have generated HA-reinforced, hydrogel-based scaffolds which have high water content and have biomimetic properties. Reinforcing polymeric scaffolds with micro/nanoparticles improve their mechanical properties and render them bioactive. In this study, hydroxyapatite (HA) is incorporated into 5% (w/v) gelatin methacrylate (GelMA) hydrogels at 1, 5, and 20 mg mL −1 concentrations. The material properties of these composite gels are characterized through swelling, degradation, and compression tests. Using 3D cell encapsulation, the cytocompatibility and osteogenic differentiation of preosteoblasts are evaluated to assess the biological properties of the composite scaffolds. The in vitro assays demonstrate increasing cell prolife...

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“…7 shows the effects of G-reinforced PEEK on osseointegration and reveals the difference among samples with different G concentrations. Compared with control PEEK and 0.1% G-PEEK samples, 1% G-PEEK and 5% G-PEEK samples are surrounded with greater amount of bone.…”

mentioning

confidence: 99%

Graphene Reinforced Polyether Ether Ketone Nanocomposites for Bone Repair Applications

Jiang¹,

Tan²,

He³

et al. 2020

Preprint

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To improve the performance of polyether ether ketone matrix (PEEK) in hard tissue repair and replacement applications, we fabricated graphene (G) reinforced PEEK with graded G concentrations (0.1%-5%) through injection molding. The mechanical properties, surface morphology, chemical composition and thermal stability of the composites have been characterized through universal mechanical testing, scanning electron microscopy, contact-angle measurement, transmission electron microscope, X-ray photoelectron spectroscopy, X-ray diffraction and thermal analysis system. The biocompatibility has been assessed in vitro and the bone repair function of the composite implant have been assessed in vivo using a rabbit mandibular bone defect model. Mechanical testing results suggest that the composite samples have compressive moduli similar to that of the natural bone. Although addition of G into PEEK does not significantly influence the composite tensile, flexural or compressive moduli, it can significantly enhance the ductility and toughness of the material. On the other hand, all G-reinforced PEEK implants demonstrated enhanced adhesion and differentiation of rat bone marrow stromal cells (BMSCs), with 5% G-PEEK showing the highest bioactivity among all samples. The in vivo osseointegration data further revealed that 5% G-PEEK has the best effect in promoting osseointegration and bone regeneration, in both early stage and late stage bone re-growth. Study shows that our G-reinforced PEEK-based implants provides a promising strategy for enhancing the performance of future regenerative bone implants.<br>

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Fabrication of a novel hydroxyapatite/polyether ether ketone surface nanocomposite via friction stir processing for orthopedic and dental applications

Cited by 20 publications

References 41 publications

Review on Development and Dental Applications of Polyetheretherketone-Based Biomaterials and Restorations

Review on Development and Dental Applications of Polyetheretherketone-Based Biomaterials and Restorations

Hydroxyapatite‐Incorporated Composite Gels Improve Mechanical Properties and Bioactivity of Bone Scaffolds

Graphene Reinforced Polyether Ether Ketone Nanocomposites for Bone Repair Applications

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