Fabrication of a Novel Fibrous Mat Based on Gliadin/Ethylcellulose Incorporated with Triamcinolone for Treatment of Oral Ulcers

Alipour, Mahdieh; Aghazadeh, Marziyeh; Ramezani, Soghra; Taherzadeh, Sana; Ghorbani, Marjan; Aghazadeh, Zahra

doi:10.1007/s10924-021-02365-2

Cited by 3 publications

(2 citation statements)

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“…To evaluate the anti-inflammatory and antioxidative properties of hesperetin and hesperetin nanocrystals on inflamed hDPSCs, the antioxidative and anti-inflammatory tests were performed as mentioned previously 45 . Briefly, hDPSCs were cultured on 6 well plates (1 × 10 6 ) and inflamed with 10 ng/ml LPS of E. Coli.…”

Section: Methodsmentioning

confidence: 99%

Synthesis, characterization, and evaluation of Hesperetin nanocrystals for regenerative dentistry

Alipour

Sharifi

Samiei

et al. 2023

Sci Rep

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Hesperetin (HS), a metabolite of hesperidin, is a polyphenolic component of citrus fruits. This ingredient has a potential role in bone strength and the osteogenic differentiation. The bone loss in the orofacial region may occur due to the inflammation response of host tissues. Nanotechnology applications have been harshly entered the field of regenerative medicine to improve the efficacy of the materials and substances. In the current study, the hesperetin nanocrystals were synthesized and characterized. Then, the anti-inflammatory and antioxidative effects of these nanocrystals were evaluated on inflamed human Dental Pulp Stem Cells (hDPSCs) and monocytes (U937). Moreover, the osteoinduction capacity of these nanocrystals was assessed by gene and protein expression levels of osteogenic specific markers including RUNX2, ALP, OCN, Col1a1, and BSP in hDPSCs. The deposition of calcium nodules in the presence of hesperetin and hesperetin nanocrystals was also assessed. The results revealed the successful fabrication of hesperetin nanocrystals with an average size of 100 nm. The levels of TNF, IL6, and reactive oxygen species (ROS) in inflamed hDPSCs and U937 significantly decreased in the presence of hesperetin nanocrystals. Furthermore, these nanocrystals induced osteogenic differentiation in hDPSCs. These results demonstrated the positive and effective role of fabricated nanocrystal forms of this natural ingredient for regenerative medicine purposes.

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Section: Methodsmentioning

confidence: 99%

Synthesis, characterization, and evaluation of Hesperetin nanocrystals for regenerative dentistry

Alipour

Sharifi

Samiei

et al. 2023

Sci Rep

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“…Meanwhile, the addition of tretinoin improved the mechanical strength and thermal stability of the nanofibrous mat. The interaction of trimethoprim with alcohol-soluble proteins and EC increases the porosity of the nanofibrous mat [ 139 ]. This inspiration can reduce the pain and inflammation of oral ulcers by corticosteroids.…”

Section: Electrospinning In the Treatment Of Oral Ulcersmentioning

confidence: 99%

Advances in the Application of Electrospun Drug-Loaded Nanofibers in the Treatment of Oral Ulcers

et al. 2022

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Oral ulcers affect oral and systemic health and have high prevalence in the population. There are significant individual differences in the etiology and extent of the disease among patients. In the treatment of oral ulcers, nanofiber films can control the drug-release rate and enable long-term local administration. Compared to other drug-delivery methods, nanofiber films avoid the disadvantages of frequent administration and certain side effects. Electrospinning is a simple and effective method for preparing nanofiber films. Currently, electrospinning technology has made significant breakthroughs in energy-saving and large-scale production. This paper summarizes the polymers that enable oral mucosal adhesion and the active pharmaceutical ingredients used for oral ulcers. Moreover, the therapeutic effects of currently available electrospun nanofiber films on oral ulcers in animal experiments and clinical trials are investigated. In addition, solvent casting and cross-linking methods can be used in conjunction with electrospinning techniques. Based on the literature, more administration systems with different polymers and loading components can be inspired. These administration systems are expected to have synergistic effects and achieve better therapeutic effects. This not only provides new possibilities for drug-loaded nanofibers but also brings new hope for the treatment of oral ulcers.

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An injectable chitosan-based hydrogel reinforced by oxidized nanocrystalline cellulose and mineral trioxide aggregate designed for tooth engineering applications

et al. 2022

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Fabrication of a Novel Fibrous Mat Based on Gliadin/Ethylcellulose Incorporated with Triamcinolone for Treatment of Oral Ulcers

Cited by 3 publications

References 50 publications

Synthesis, characterization, and evaluation of Hesperetin nanocrystals for regenerative dentistry

Synthesis, characterization, and evaluation of Hesperetin nanocrystals for regenerative dentistry

Advances in the Application of Electrospun Drug-Loaded Nanofibers in the Treatment of Oral Ulcers

An injectable chitosan-based hydrogel reinforced by oxidized nanocrystalline cellulose and mineral trioxide aggregate designed for tooth engineering applications

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