Fabrication of a multi-level drug release platform with liposomes, chitooligosaccharides, phospholipids and injectable chitosan hydrogel to enhance anti-tumor effectiveness

Li, Riwang; Lyu, Yang; Luo, Simin; Wang, Huajun; Zheng, Xiaofei; Li, Lihua; Ao, Ningjian; Zha, Zhengang

doi:10.1016/j.carbpol.2021.118322

Cited by 32 publications

(18 citation statements)

References 22 publications

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“…The charge of liposomes was critical to stability and encapsulation efficiency. As the potential increased, the repulsive force between liposomes became stronger, resulting in a more stabilized colloidal dispersion system (Li et al., 2021). The zeta potential of liposomes increased remarkably ( p < 0.05) after adding chitosan (Figure 2a).…”

Section: Resultsmentioning

confidence: 99%

“…At a chitosan concentration of 0.5%, the encapsulation efficiency barely increased compared with IgY‐LP ( p > 0.05), which might be due to the multilayer encapsulation of chitosan preventing the leakage of IgY from the liposomes. The enhancement of encapsulation efficiency indicated that the liposomes were more stable, and the multilayer coating of chitosan prevented leakage of IgY (Li et al., 2021). The encapsulation efficiency of IgY‐CS‐LP achieved a peak value of 77.51 ± 0.8% at a chitosan concentration of 0.8% (Figure 2b).…”

Section: Resultsmentioning

confidence: 99%

“…The in vitro release of IgY in liposomes was carried out with the method of Li et al. (2021) with appropriate modifications. The liposomes suspension was mixed 1:1 with PBS, and the liposomes suspension was released in vitro into a shaker with a rotation speed of 150 rpm at 37°C.…”

Section: Methodsmentioning

confidence: 99%

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Encapsulation efficiency and oral delivery stability of chitosan–liposome‐encapsulated immunoglobulin Y

Tang

Salama

Xia

et al. 2022

Journal of Food Science

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The degradation of acidic gastric juice on immunoglobulin Y (IgY) leads to destruction on the structural and loss of the bioactivity, limiting the bioavailability of oral IgY and its research or application in adjuvant treatment of diseases. In this work, it was surmounted with IgY‐loaded chitosan–liposomes prepared by supercritical carbon dioxide‐assisted method. A range of chitosan concentrations (0%, 0.5%, 0.8%, 1.1%, and 1.4%) were selected to explore the influence of chitosan concentration on the encapsulation effectiveness, stability, and in vitro‐simulated digestive release properties of liposome‐encapsulated IgY. The results displayed that owing to the robust interaction between chitosan and liposomes, the particle size, encapsulation efficiency, and stability of liposomes reached the optimal state at a chitosan concentration of 0.8%, with the encapsulation efficiency reaching 77.51%. Moreover, the liposomes could be stored at 4°C for 9 days without obvious sedimentation. The zeta potential of liposomes containing 0.8% chitosan was higher than that of samples without chitosan at high salt concentration treatment. In vitro release experiments demonstrated that liposomes fitted well in the Peppas equation. Chitosan‐coated liposomes were capable of delaying the release of IgY in the stomach during simulated digestion, allowing more IgY to be released in the intestine. To sum up, Chitosan played a vital role in maintaining the stability and encapsulation of IgY, and the results of this work provide a theoretical basis for the development and utilization of chitosan and the protection of activity of IgY when administered orally. Practical Application IgY serves as a bioactive substance with anti‐inflammatory, antibacterial, and antioxidant functions. However, it is far from satisfactory for the oral delivery activity of IgY. Encapsulation of liposomes contributed to alleviate the release of IgY in the stomach. However, liposomes were less stable and not efficient enough to encapsulate IgY. This study demonstrated that the addition of 0.8% chitosan could effectively enhance the encapsulation efficiency of liposomes and improved the stability of liposomes. It might contribute to the solution of the oral delivery activity of IgY and provide a promising idea for the utilization of chitosan.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Encapsulation efficiency and oral delivery stability of chitosan–liposome‐encapsulated immunoglobulin Y

Tang

Salama

Xia

et al. 2022

Journal of Food Science

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“…218 Injectable thiolated chitosan hydrogel was used to fix curcumin (Cur) loaded liposomes (Cur@Lip) after chronological coating with positive chitooligosaccharides (Cur@Lip-Cos) and negative phospholipids (Cur@Lip-Cos-PC). 219 Confined immobilization and sustained release of Cur to inhibit MCF-7 (tumor cell) growth were reported recently as two major biomedical utilizations from that system. The tumor cell proliferation was diminished with increasing concentration of Cur in gel observed through confocal laser microscope (CLSM) as demonstrated in Figure 17.…”

Section: A Brief Overview Of Bioapplicationsmentioning

confidence: 99%

Recent Development of Polysaccharide-Derived Hydrogel: Properties, Stimuli-Responsiveness and Bioapplications

Mukherjee

2022

Preprint

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Hydrogels are three-dimensional, hydrophilic, polymeric frameworks, constructed through diverse physical or chemical crosslinks. Recent research focuses on their physiological stimuli sensitivity enhancing bioapplications. Biopolymers with responsiveness to local environment like temperature, pH etc. form the foundation in this regard, around which all major natural processes are circulated. Polysaccharides, being most the abundant biopolymers and essential constituent of our daily food like cereals and fruits, are readily available in nature. Hence, among numerous biomacromolecules, polysaccharides are extensively used to prepare hydrogel recently. However, incorporation of certain properties to these gels through derivatization can trigger stimuli responsiveness suitable for various applications especially in biomedical field inspired from the mother nature. For example, in situ cross-linking ability may deliver an intermediate platform between solid scaffolds and saline injections through reversible or irreversible sol-gel transition. Easy injectability provides patient’s relief through reducing recovery time and inflectional hazards. Self recovery of gel within body results automatic inflammation and damage recovery of tissues. This review provides a detail impression on the synthesis of natural polysaccharide derived hydrogel network with structural classification to bulk, supramolecular, micro and nano gel. Several properties important from biomedical point such as in situ, injectable, self healing nature of these hydrogels and various physical, chemical, or biochemical stimuli-responsive characteristics are discussed further. Lastly, their major bioapplications are highlighted.

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“…This category of hydrogels includes electro-conductive gels [ 24 ] and pH-sensitive gels [ 25 ]. Other branches in hydrogel research deal with implementations of preformulated drugs such as microemulsions [ 26 ], nanocomposites [ 27 ], or liposomes [ 28 ] into hydrogels structures. A lot of studies concerning IBU formulation in hydrogels investigate the properties of new types of hydrogels and compare them with commercially available products.…”

Section: Introductionmentioning

confidence: 99%

Comparative Study of Polysaccharide-Based Hydrogels: Rheological and Texture Properties and Ibuprofen Release

Mikušová

Ferková

Dominika

et al. 2022

Gels

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Polysaccharides are attractive gelling agents in pharmacy due to their safety, biocompatibility, biodegradability, relatively easy way of preparation, and low price. Due to their variable physical-chemical properties, polysaccharides have potentialities to be used for designing new drug delivery systems for controlled drug release. In this comparative study, rheological and texture properties as well as the in vitro release of model drug ibuprofen (IBU) with 11 polysaccharide-based hydrogels were investigated. The in vitro release of IBU significantly differed between (i) neutral (hydroxy/alkylcelluloses), (ii) anionic (carboxyalkylcellulose and its sodium salt, tragacanth, carrageenan, xanthan gum), and (iii) cationic (chitosans) hydrogels due to different contribution of provided interactions and viscosity within the hydrogel groups. The drug release kinetics of each hydrogel system was evaluated for five kinetic models. Several combinations of cationic hydrogels with neutral or anionic ones were performed to illustrate possibilities of providing modified IBU release profiles. In this context, chitosan was presented as an effective modifier of diffusion profiles for negatively charged drugs formulated into combined polymeric systems, providing their prolonged release. The most appropriate hydrogel for the topical application (i.e., providing favorable rheological and texture properties along with the highest drug release) was selected from a studied series of polysaccharide-based hydrogels.

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Fabrication of a multi-level drug release platform with liposomes, chitooligosaccharides, phospholipids and injectable chitosan hydrogel to enhance anti-tumor effectiveness

Cited by 32 publications

References 22 publications

Encapsulation efficiency and oral delivery stability of chitosan–liposome‐encapsulated immunoglobulin Y

Encapsulation efficiency and oral delivery stability of chitosan–liposome‐encapsulated immunoglobulin Y

Recent Development of Polysaccharide-Derived Hydrogel: Properties, Stimuli-Responsiveness and Bioapplications

Comparative Study of Polysaccharide-Based Hydrogels: Rheological and Texture Properties and Ibuprofen Release

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