Fabrication of a composite 3D-printed titanium alloy combined with controlled in situ drug release to prevent osteosarcoma recurrence

Fan, Daoyang; Zhang, Chaoqi; Wang, Hufei; Wei, Qingguang; Cai, Hong; Wei, Feng; Bian, Zhilei; Liu, Weifeng; Wang, Xing; Liu, Zhong Jun

doi:10.1016/j.mtbio.2023.100683

Cited by 3 publications

(1 citation statement)

References 58 publications

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“…A growing number of studies emphasize the importance of the synergistic effects of surface structure and chemical modification to enhance the biological function of titanium-based materials. Micron/nano-scale pore/tube structures can be constructed on titanium implants by 3D printing and anodizing technology, which can greatly promote osteogenesis and osseointegration and facilitate bone trauma repair [5][6][7][8]. The multi-scale pore/tube structures provide platform for the loading and release of anticancer elements/drugs such as doxorubicin, apoptosis-inducing ligand (Apo2L/TRAIL), paclitaxel, and selenium, enabling local treatment to prevent tumor recurrence.…”

Section: Introductionmentioning

confidence: 99%

An ascorbic acid-decorated nanostructured surface on titanium inhibits breast cancer development and promotes osteogenesis

Li,

Liu,

Shi

et al. 2023

Biomed. Mater.

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The chest wall is the most frequent metastatic site of breast cancer (BC) and the metastasis usually occurs in a solitary setting. Chest wall resection is a way to treat solitary BC metastasis, but intraoperative bone defects and local tumor recurrence still affect the life quality of patients. Titanium-based prostheses are widely used for chest wall repair and reconstruction, but their inherent bio-inertness makes their clinical performance unfavorable. Nanostructured surfaces can give titanium substrates the ability to excellently modulate a variety of cellular functions. Ascorbic acid is a potential stimulator of tumor suppression and osteogenic differentiation. An ascorbic acid-decorated nanostructured titanium surface was prepared through alkali treatment and spin-coating technique and its effects on the biological responses of BC cells and osteoblasts were assessed. The results exhibited that the nanorod structure and ascorbic acid synergistically inhibited the proliferation, spreading, and migration of BC cells. Additionally, the ascorbic acid-decorated nanostructured surface significantly promoted the proliferation and osteogenic differentiation of osteoblasts. This work may provide valuable references for the clinical application of titanium materials in chest wall reconstruction after the resection of metastatic BC.

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Section: Introductionmentioning

confidence: 99%

An ascorbic acid-decorated nanostructured surface on titanium inhibits breast cancer development and promotes osteogenesis

Li,

Liu,

Shi

et al. 2023

Biomed. Mater.

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Mg alloys with antitumor and anticorrosion properties for orthopedic oncology: A review from mechanisms to application strategies

Lin,

Wei,

Yang

2024

APL Bioengineering

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As a primary malignant bone cancer, osteosarcoma (OS) poses a great threat to human health and is still a huge challenge for clinicians. At present, surgical resection is the main treatment strategy for OS. However, surgical intervention will result in a large bone defect, and some tumor cells remaining around the excised bone tissue often lead to the recurrence and metastasis of OS. Biomedical Mg-based materials have been widely employed as orthopedic implants in bone defect reconstruction, and, especially, they can eradicate the residual OS cells due to the antitumor activities of their degradation products. Nevertheless, the fast corrosion rate of Mg alloys has greatly limited their application scope in the biomedical field, and the improvement of the corrosion resistance will impair the antitumor effects, which mainly arise from their rapid corrosion. Hence, it is vital to balance the corrosion resistance and the antitumor activities of Mg alloys. The presented review systematically discussed the potential antitumor mechanisms of three corrosion products of Mg alloys. Moreover, several strategies to simultaneously enhance the anticorrosion properties and antitumor effects of Mg alloys were also proposed.

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Multicomponent 3D-printed Collagen-based Scaffolds for Cartilage Regeneration: Recent Progress, Developments, and Emerging Technologies

Mikaeeli Kangarshahi,

Naghib

2024

COC

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Cartilage tissue presents challenges in terms of repair and regeneration due to its inherent limitations in self-healing and the scarcity of available donors. Cartilage damage can result in the development of joint problems characterized by symptoms, such as pain, swelling, and osteoarthritis. Collagen scaffolds are extensively used as biomimetic substances for cartilage engineering due to their ability to offer structural, biochemical, and mechanical signals for chondrocytes. Nevertheless, traditional techniques for producing collagen scaffolds frequently yield inadequate pore architecture, diminished mechanical robustness, and restricted form accuracy. Hence, 3D printing is a developing method that can surpass these restrictions by allowing accurate manipulation of the shape, porousness, and makeup of the scaffold. 3D printing has the capability to include various materials and cells in the scaffolds, resulting in the production of intricate and personalized tissue structures. This research examines the latest progress in utilizing 3D printing to create collagen scaffolds for the purpose of regenerating cartilage. This text discusses the different sources of collagen, methods of cross-linking, techniques for printing, and strategies for post-processing that are employed to improve the performance of scaffolds. Furthermore, it discusses the difficulties and potential future paths of utilizing 3D printing to create collagen scaffolds for the purpose of regenerating cartilage.

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Fabrication of a composite 3D-printed titanium alloy combined with controlled in situ drug release to prevent osteosarcoma recurrence

Cited by 3 publications

References 58 publications

An ascorbic acid-decorated nanostructured surface on titanium inhibits breast cancer development and promotes osteogenesis

An ascorbic acid-decorated nanostructured surface on titanium inhibits breast cancer development and promotes osteogenesis

Mg alloys with antitumor and anticorrosion properties for orthopedic oncology: A review from mechanisms to application strategies

Multicomponent 3D-printed Collagen-based Scaffolds for Cartilage Regeneration: Recent Progress, Developments, and Emerging Technologies

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